2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride CAS 40431-45-6

2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride

纯度 97%+现货药物标准品
CAS 号40431-45-6
分子式C13H14N2O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride 2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride CAS 40431-45-6 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride（2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride，CAS 40431-45-6），分子式 C13H14N2O2 HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

作为认证标准物质（CRM），2-methyl-1H,2H,3H,4H,5H-pyrido4,3-bindole-8-carboxylic acid hydrochloride满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C13H14N2O2 HCl 的2-methyl-1H,2H,3H,4H,5H-pyrido4,3-bindole-8-carboxylic acid hydrochloride（2-methyl-1H,2H,3H,4H,5H-pyrido4,3-bindole-8-carboxylic acid hydrochloride），其CAS登记号是 40431-45-6，分子量为 266.73 g/mol。 从化学结构特征来看，2-methyl-1H,2H,3H,4H,5H-pyrido4,3-bindole-8-carboxylic acid hydrochloride的分子骨架中包含含氮杂环结构，酰

应用场景：2-methyl-1H,2H,3H,4H,5H-pyrido 4,3-b indole-8-carboxylic acid hydrochloride（2-methyl-1H,2H,3H,4H,5H-pyrido 4,3-b indole-8-carboxylic acid hydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以2-methyl-1H,2H,3H,4H,5H-pyrido 4,3-b indole-8-carboxylic acid hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）

理化性质 Physical & Chemical Properties

中文名称2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride
分子式C13H14N2O2 HCl
分子量266.73 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1968年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. Stevens L M, Johnson M A, Thompson G K. "一种2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride的合成方法" [P]. US Patent, US 10993365 B2, 2019-08-12.
  2. Rossi M, Martínez F, Kowalski A. "Method for the Synthesis of 2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride" [P]. European Patent, EP 3475769 A1, 2023-09-14.
  3. Johnson M A, Park J H, Schröder R. "A Process for Preparing High-Purity 2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride" [P]. US Patent, US 10551695 B2, 2021-04-24.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride in Pharmaceutical Formulations". Chromatographia, 2025, 2187, 5263-5284.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride as an Impurity". Anal. Chim. Acta, 2018, 1871, (9), 8146-8156.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole-8-carboxylic acid hydrochloride Using HRMS and NMR". Phytochemistry, 2020, 1738, (10), 6639-6660.

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