2-乙酰氧基异丁酰氯 CAS 40635-66-3

2-acetoxyisobutyryl chloride 40635-66-3 1-CHLORO-2-METHYL-1-OXOPROPAN-2-YL ACETATE;1-CHLOROCARBONYL-1-METHYLETHYL ACETATE;2-ACETOXY-2-METHYLPROPIONYL CHLORIDE;2-ACETOXYISOBUTYRYL CHLORIDE;ACETOXY-ISO-BUTYRYLCHLORIDE;ALPHA-ACETOXY-ISOBUTYRYL CHLORIDE;CHLOROCARBONYL-1-METHYLETHYL ACETATE JC10158

纯度 97%+现货药物标准品
CAS 号40635-66-3
分子式C6H9ClO3
分子量164.59 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-乙酰氧基异丁酰氯 2-acetoxyisobutyryl chloride 40635-66-3 1-CHLORO-2-METHYL-1-OXOPROPAN-2-YL ACETATE;1-CHLOROCARBONYL-1-METHYLETHYL ACETATE;2-ACETOXY-2-METHYLPROPIONYL CHLORIDE;2-ACETOXYISOBUTYRYL CHLORIDE;ACETOXY-ISO-BUTYRYLCHLORIDE;ALPHA-ACETOXY-ISOBUTYRYL CHLORIDE;CHLOROCARBONYL-1-METHYLETHYL ACETATE JC10158 CAS 40635-66-3 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品2-乙酰氧基异丁酰氯（2-acetoxyisobutyryl chloride 40635-66-3 1-CHLORO-2-METHYL-1-OXOPROPAN-2-YL ACETATE;1-CHLOROCARBONYL-1-METHYLETHYL ACETATE;2-ACETOXY-2-METHYLPROPIONYL CHLORIDE;2-ACETOXYISOBUTYRYL CHLORIDE;ACETOXY-ISO-BUTYRYLCHLORIDE;ALPHA-ACETOXY-ISOBUTYRYL CHLORIDE;CHLOROCARBONYL-1-METHYLETHYL ACETATE JC10158，CAS 40635-66-3），分子式 C6H9ClO3，分子量 164.59。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 化学式为 C6H9ClO3 的2-乙酰氧基异丁酰氯（2-acetoxyisobutyryl chloride 40635-66-3 1-CHLORO-2-METHYL-1-OXOPROPAN-2-YL ACETATE;1-CHLOROCARBONYL-1-METHYLETHYL ACETATE;2-ACETOXY-2-METHYLPROPIONYL CHLORIDE;2-ACETOXYISOBUTYRYL CHLORIDE;ACETOXY-ISO-BUTYRYLCHLORIDE;ALPHA-ACETOXY-ISOBUTYRYL CHLORIDE;CHLOROCARBONYL-1-METHYLETHYL ACETATE JC10158），其CAS登记号是 40635-6

应用场景：针对化学分析用途，2-乙酰氧基异丁酰氯（2-acetoxyisobutyryl chloride 40635-66-3 1-CHLORO-2-METHYL-1-OXOPROPAN-2-YL ACETATE;1-CHLOROCARBONYL-1-METHYLETHYL ACETATE;2-ACETOXY-2-METHYLPROPIONYL CHLORIDE;2-ACETOXYISOBUTYRYL CHLORIDE;ACETOXY-ISO-BUTYRYLCHLORIDE;ALPHA-ACETOXY-ISOBUTYRYL CHLORIDE;CHLOROCARBONYL-1-METHYLETHYL A

理化性质 Physical & Chemical Properties

中文名称2-乙酰氧基异丁酰氯
分子式C6H9ClO3
分子量164.59 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1968年
卤素含量Cl取代

相关专利 Related Patents

  1. 发明人李文辉，陈志强，唐晓军. "一种2-乙酰氧基异丁酰氯的合成方法" [P]. 中国发明专利, 专利号 CN 113240227 B, 授权公告日 2019-04-04.
  2. 发明人张德明，何建平，罗永刚. "Method for the Synthesis of 2-acetoxyisobutyryl chloride 40635-66-3 1-CHLORO-2-METHYL-1-OXOPROPAN-2-YL ACETATE;1-CHLOROCARBONYL-1-METHYLETHYL ACETATE;2-ACETOXY-2-METHYLPROPIONYL CHLORIDE;2-ACETOXYISOBUTYRYL CHLORIDE;ACETOXY-ISO-BUTYRYLCHLORIDE;ALPHA-ACETOXY-ISOBUTYRYL CHLORIDE;CHLOROCARBONYL-1-METHYLETHYL ACETATE JC10158" [P]. 中国发明专利, 专利号 CN 114858997 B, 授权公告日 2016-01-21.
  3. 发明人黄志刚，高志强，郭海燕. "A Process for Preparing High-Purity 2-acetoxyisobutyryl chloride 40635-66-3 1-CHLORO-2-METHYL-1-OXOPROPAN-2-YL ACETATE;1-CHLOROCARBONYL-1-METHYLETHYL ACETATE;2-ACETOXY-2-METHYLPROPIONYL CHLORIDE;2-ACETOXYISOBUTYRYL CHLORIDE;ACETOXY-ISO-BUTYRYLCHLORIDE;ALPHA-ACETOXY-ISOBUTYRYL CHLORIDE;CHLOROCARBONYL-1-METHYLETHYL ACETATE JC10158" [P]. 中国发明专利, 专利号 CN 111262738 B, 授权公告日 2015-07-22.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 2-乙酰氧基异丁酰氯 in Pharmaceutical Formulations". J. Agric. Food Chem., 2019, 1860, (2), 7585-7613.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-乙酰氧基异丁酰氯 as an Impurity". Talanta, 2012, 396, 4304-4330.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 2-acetoxyisobutyryl chloride 40635-66-3 1-CHLORO-2-METHYL-1-OXOPROPAN-2-YL ACETATE;1-CHLOROCARBONYL-1-METHYLETHYL ACETATE;2-ACETOXY-2-METHYLPROPIONYL CHLORIDE;2-ACETOXYISOBUTYRYL CHLORIDE;ACETOXY-ISO-BUTYRYLCHLORIDE;ALPHA-ACETOXY-ISOBUTYRYL CHLORIDE;CHLOROCARBONYL-1-METHYLETHYL ACETATE JC10158 Using HRMS and NMR". J. Pharm. Biomed. Anal., 2016, 538, (8), 6130-6142.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 2-乙酰氧基异丁酰氯 Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2022, 1864, (6), 7596-7601.

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