(<I>S</I>,<I>R</I>)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并[2,1-a:3,4-a′]二萘-4-基)-(1-苯基乙基)胺 CAS 422509-53-3

(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)[(1R)-1-phenylethyl]amine 422509-53-3 (+)-N-1(R1-PHENYLETHYL)-DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE, (11B,S);(R)-N-(1-PHENYLETHYL)DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A3,4-A']DINAPHTHALEN-4-YL)[(1R)-1-PHENYLETHYL]AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)[(1R)-1-PHENYLETHYL]AMINE;(S)-N-(1-PHENYLETHYL)DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S,R)-(+)-(3,5-DIOXA-4-PHOSPHACYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)-(1-PHENYLETHYL)AMINE;(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)[(1R)-1-phenylethyl]amine SC11357

纯度 97%+现货药物标准品
CAS 号422509-53-3
分子式C28H48NO2P
分子量461.66 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>,<I>R</I>)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并[2,1-a:3,4-a′]二萘-4-基)-(1-苯基乙基)胺 (S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)[(1R)-1-phenylethyl]amine 422509-53-3 (+)-N-1(R1-PHENYLETHYL)-DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE, (11B,S);(R)-N-(1-PHENYLETHYL)DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A3,4-A']DINAPHTHALEN-4-YL)[(1R)-1-PHENYLETHYL]AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)[(1R)-1-PHENYLETHYL]AMINE;(S)-N-(1-PHENYLETHYL)DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S,R)-(+)-(3,5-DIOXA-4-PHOSPHACYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)-(1-PHENYLETHYL)AMINE;(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)[(1R)-1-phenylethyl]amine SC11357 CAS 422509-53-3 结构式 Chemical Structure

产品介绍 Description

CAS 422509-53-3 对应的(<I>S</I>,<I>R</I>)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并[2,1-a:3,4-a′]二萘-4-基)-(1-苯基乙基)胺（(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)[(1R)-1-phenylethyl]amine 422509-53-3 (+)-N-1(R1-PHENYLETHYL)-DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE, (11B,S);(R)-N-(1-PHENYLETHYL)DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A3,4-A']DINAPHTHALEN-4-YL)[(1R)-1-PHENYLETHYL]AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)[(1R)-1-PHENYLETHYL]AMINE;(S)-N-(1-PHENYLETHYL)DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S,R)-(+)-(3,5-DIOXA-4-PHOSPHACYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)-(1-PHENYLETHYL)AMINE;(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)[(1R)-1-phenylethyl]amine SC11357）为 CATO 佳途药物标准品产品线成员。分子式 C28H48NO2P，分子量 461.66。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

(<I>S</I>,<I>R</I>)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并2,1-a:3,4-a′二萘-4-基)-(1-苯基乙基)胺的产生途径与其化学式中甾体骨架，酰胺类，有机磷，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 422509-53-3 对应的化合物(<I>S</I>,<I>R</I>)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并2,1-a:3,4-a′二萘-4-基)-(1-苯基乙基)胺（英文标识 (S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta2,1-a;3,4-a'dinaphthalen-4-yl)(1R)-1-phenylethylamine 422509-53-3 (+)-N-1(R1-PHENYLETHYL)-DINAPHTHO2,1-D:1',2'-F1,3,2DIOXAPHOSPHEPIN-4-AMINE, (11B,S);(R)-N-(1-PHENYLETHYL)DINAPHTHO2,1-D:1',2'-F1,3,2DIOXAPH

应用场景：针对化学分析用途，(<I>S</I>,<I>R</I>)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并 2,1-a:3,4-a′ 二萘-4-基)-(1-苯基乙基)胺（(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta 2,1-a;3,4-a' dinaphthalen-4-yl) (1R)-1-phenylethyl amine 422509-53-3 (+)-N-1(R1-PHENYLETHYL)-DINAPHTHO 2,1-D:1',2'-F 1,3,2 DIOXAPHOSPHEPIN-4-AMINE, (11B,S);(R)-N-(1-PHENYLETHYL

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>,<I>R</I>)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并[2,1-a:3,4-a′]二萘-4-基)-(1-苯基乙基)胺
分子式C28H48NO2P
分子量461.66 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
含氮原子数1

相关专利 Related Patents

  1. 发明人张德明，胡光，赵玉洁. "一种(<I>S</I>,<I>R</I>)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并[2,1-a:3,4-a′]二萘-4-基)-(1-苯基乙基)胺的合成方法" [P]. 中国发明专利, 专利号 CN 112242545 A, 授权公告日 2018-10-22.
  2. Patel M V, Brown S R, Hughes D C. "Method for the Synthesis of (S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)[(1R)-1-phenylethyl]amine 422509-53-3 (+)-N-1(R1-PHENYLETHYL)-DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE, (11B,S);(R)-N-(1-PHENYLETHYL)DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A3,4-A']DINAPHTHALEN-4-YL)[(1R)-1-PHENYLETHYL]AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)[(1R)-1-PHENYLETHYL]AMINE;(S)-N-(1-PHENYLETHYL)DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S,R)-(+)-(3,5-DIOXA-4-PHOSPHACYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)-(1-PHENYLETHYL)AMINE;(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)[(1R)-1-phenylethyl]amine SC11357" [P]. US Patent, US 9575443 B2, 2024-10-08.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>,<I>R</I>)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并[2,1-a:3,4-a′]二萘-4-基)-(1-苯基乙基)胺 in Pharmaceutical Formulations". J. Agric. Food Chem., 2023, 552, 6215-6219.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>,<I>R</I>)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并[2,1-a:3,4-a′]二萘-4-基)-(1-苯基乙基)胺 as an Impurity". Anal. Chim. Acta, 2019, 354, (8), 8312-8323.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of (S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)[(1R)-1-phenylethyl]amine 422509-53-3 (+)-N-1(R1-PHENYLETHYL)-DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE, (11B,S);(R)-N-(1-PHENYLETHYL)DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A3,4-A']DINAPHTHALEN-4-YL)[(1R)-1-PHENYLETHYL]AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)[(1R)-1-PHENYLETHYL]AMINE;(S)-N-(1-PHENYLETHYL)DINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S,R)-(+)-(3,5-DIOXA-4-PHOSPHACYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)-(1-PHENYLETHYL)AMINE;(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)[(1R)-1-phenylethyl]amine SC11357 Using HRMS and NMR". Chromatographia, 2023, 676, (8), 5437-5460.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate (<I>S</I>,<I>R</I>)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并[2,1-a:3,4-a′]二萘-4-基)-(1-苯基乙基)胺 Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2014, 2348, 146-152.

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