CAS 428863-50-7

UMD07X179E 428863-50-7 Certolizumab Pegol Certolizumab pegol [USAN:INN:BAN:JAN] Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated. Molecular weight is 47,696 daltons (unpegylated moiety) CDP 870 PHA 738144 PHA-738144 Cimzia UNII-UMD07X179E CDP870 CZP Certolizumab HSDB 7848

纯度 97%+现货药物标准品
CAS 号428863-50-7
分子式C24H22F3N
分子量381.43 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

UMD07X179E 428863-50-7 Certolizumab Pegol Certolizumab pegol [USAN:INN:BAN:JAN] Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated. Molecular weight is 47,696 daltons (unpegylated moiety) CDP 870 PHA 738144 PHA-738144 Cimzia UNII-UMD07X179E CDP870 CZP Certolizumab HSDB 7848 CAS 428863-50-7 结构式 Chemical Structure

产品介绍 Description

CAS 428863-50-7 对应的（UMD07X179E 428863-50-7 Certolizumab Pegol Certolizumab pegol [USAN:INN:BAN:JAN] Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated. Molecular weight is 47,696 daltons (unpegylated moiety) CDP 870 PHA 738144 PHA-738144 Cimzia UNII-UMD07X179E CDP870 CZP Certolizumab HSDB 7848）为 CATO 佳途药物标准品产品线成员。分子式 C24H22F3N，分子量 381.43。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

的产生途径与其化学式中含氮杂环结构，含氰基，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 428863-50-7 对应的化合物（英文标识 UMD07X179E 428863-50-7 Certolizumab Pegol Certolizumab pegol USAN:INN:BAN:JAN Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse

应用场景：在化学分析实验室中，（CAS 428863-50-7）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于2-8°C冷藏保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称
分子式C24H22F3N
分子量381.43 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）13.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
卤素含量F取代
含氮原子数1

相关专利 Related Patents

  1. 发明人钱学锋，韩伟，陈志强. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 111892777 B, 授权公告日 2017-03-11.
  2. 发明人黄志刚，赵玉洁，沈红梅. "Method for the Synthesis of UMD07X179E 428863-50-7 Certolizumab Pegol Certolizumab pegol [USAN:INN:BAN:JAN] Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated. Molecular weight is 47,696 daltons (unpegylated moiety) CDP 870 PHA 738144 PHA-738144 Cimzia UNII-UMD07X179E CDP870 CZP Certolizumab HSDB 7848" [P]. 中国发明专利, 专利号 CN 115955263 A, 授权公告日 2021-10-08.
  3. Klinger H, Stevens L M, Williams B T. "A Process for Preparing High-Purity UMD07X179E 428863-50-7 Certolizumab Pegol Certolizumab pegol [USAN:INN:BAN:JAN] Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated. Molecular weight is 47,696 daltons (unpegylated moiety) CDP 870 PHA 738144 PHA-738144 Cimzia UNII-UMD07X179E CDP870 CZP Certolizumab HSDB 7848" [P]. US Patent, US 9844628 B2, 2020-02-14.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Sep. Sci., 2022, 1652, 4930-4957.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Chemosphere, 2020, 1408, 8870-8881.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of UMD07X179E 428863-50-7 Certolizumab Pegol Certolizumab pegol [USAN:INN:BAN:JAN] Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated. Molecular weight is 47,696 daltons (unpegylated moiety) CDP 870 PHA 738144 PHA-738144 Cimzia UNII-UMD07X179E CDP870 CZP Certolizumab HSDB 7848 Using HRMS and NMR". Environ. Sci. Technol., 2012, 1148, (1), 7944-7966.

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