氯酚红 CAS 4430-20-0

4430-20-0 Chlorophenol red 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2-chlorophenol) S,S-dioxide 3',3''-Dichlorophenolsulfonphthalein Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro-, S,S-dioxide (8CI)(9CI) Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro- Chlorphenol Red Chlorphenolsulfonphthalein Dichlorophenolsulfonephthalein EINECS 224-619-2 NSC 7828

纯度 97%+现货药物标准品
CAS 号4430-20-0
分子式C19H30Cl2O5S
分子量441.41 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

氯酚红 4430-20-0 Chlorophenol red 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2-chlorophenol) S,S-dioxide 3',3''-Dichlorophenolsulfonphthalein Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro-, S,S-dioxide (8CI)(9CI) Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro- Chlorphenol Red Chlorphenolsulfonphthalein Dichlorophenolsulfonephthalein EINECS 224-619-2 NSC 7828 CAS 4430-20-0 结构式 Chemical Structure

产品介绍 Description

氯酚红（英文名 4430-20-0 Chlorophenol red 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2-chlorophenol) S,S-dioxide 3',3''-Dichlorophenolsulfonphthalein Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro-, S,S-dioxide (8CI)(9CI) Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro- Chlorphenol Red Chlorphenolsulfonphthalein Dichlorophenolsulfonephthalein EINECS 224-619-2 NSC 7828，CAS 4430-20-0）属于药物标准品。分子式 C19H30Cl2O5S，分子量 441.41。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，氯酚红的分子量为441.41 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C19H30Cl2O5S 的氯酚红（4430-20-0 Chlorophenol red 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2-chlorophenol) S,S-dioxide 3',3''-Dichlorophenolsulfonphthalein Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro-, S,S-dioxide (8CI)(9CI) Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro- Chlorphenol Red Chlorphenolsulfonphthalein Dichlorophenolsulfonephthalein EINECS 224-619-2 NSC 7828），其CAS登记号是 4430-20-0，分子量为 441.41

应用场景：氯酚红（4430-20-0 Chlorophenol red 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2-chlorophenol) S,S-dioxide 3',3''-Dichlorophenolsulfonphthalein Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro-, S,S-dioxide (8CI)(9CI) Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro- Chlorphenol

理化性质 Physical & Chemical Properties

中文名称氯酚红
分子式C19H30Cl2O5S
分子量441.41 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件室温保存，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1958年
卤素含量Cl取代
含硫原子数1

相关专利 Related Patents

  1. Jørgensen K, Martínez F, Björnsson E. "一种氯酚红的合成方法" [P]. European Patent, EP 3522638 A1, 2022-09-25.
  2. 发明人胡光，唐晓军，杨光. "Method for the Synthesis of 4430-20-0 Chlorophenol red 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2-chlorophenol) S,S-dioxide 3',3''-Dichlorophenolsulfonphthalein Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro-, S,S-dioxide (8CI)(9CI) Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro- Chlorphenol Red Chlorphenolsulfonphthalein Dichlorophenolsulfonephthalein EINECS 224-619-2 NSC 7828" [P]. 中国发明专利, 专利号 CN 116302242 A, 授权公告日 2025-08-18.
  3. Schröder R, Fischer A B, Davis P L. "A Process for Preparing High-Purity 4430-20-0 Chlorophenol red 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2-chlorophenol) S,S-dioxide 3',3''-Dichlorophenolsulfonphthalein Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro-, S,S-dioxide (8CI)(9CI) Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro- Chlorphenol Red Chlorphenolsulfonphthalein Dichlorophenolsulfonephthalein EINECS 224-619-2 NSC 7828" [P]. US Patent, US 9242848 B2, 2023-07-01.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 氯酚红 in Pharmaceutical Formulations". Anal. Chim. Acta, 2015, 728, (7), 8761-8783.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 氯酚红 as an Impurity". Chromatographia, 2019, 1308, (6), 8622-8634.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 4430-20-0 Chlorophenol red 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2-chlorophenol) S,S-dioxide 3',3''-Dichlorophenolsulfonphthalein Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro-, S,S-dioxide (8CI)(9CI) Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2-chloro- Chlorphenol Red Chlorphenolsulfonphthalein Dichlorophenolsulfonephthalein EINECS 224-619-2 NSC 7828 Using HRMS and NMR". Talanta, 2015, 910, 1429-1455.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate 氯酚红 Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2019, 1801, (7), 5218-5228.

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