1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester CAS 454482-11-2
1,2,3,6-TETRAHYDRO-1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDRO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,2,3,6-TETRAHYDROPYRIDINE 4,4,5,5-TETRAMETHYL-2-(1-METHYL-3,5-DIHYDRO-2H-PYRID-4-YL)-1,3,2-DIOXABOROLANE 454482-11-2 BC000408
| CAS 号 | 454482-11-2 |
| 分子式 | C12H22BNO2 |
| 分子量 | 223.12 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester（英文名 1,2,3,6-TETRAHYDRO-1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDRO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,2,3,6-TETRAHYDROPYRIDINE 4,4,5,5-TETRAMETHYL-2-(1-METHYL-3,5-DIHYDRO-2H-PYRID-4-YL)-1,3,2-DIOXABOROLANE 454482-11-2 BC000408，CAS 454482-11-2）属于药物标准品。分子式 C12H22BNO2，分子量 223.12。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester的产生途径与其化学式中氨基酸衍生物，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 454482-11-2 对应的化合物1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester（英文标识 1,2,3,6-TETRAHYDRO-1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDRO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOX
应用场景：1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester（1,2,3,6-TETRAHYDRO-1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDRO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER 1
理化性质 Physical & Chemical Properties
| 中文名称 | 1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester |
| 分子式 | C12H22BNO2 |
| 分子量 | 223.12 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 2.5 |
| CAS登记年份（估） | 2025年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人王建平，黄志刚，郭海燕. "一种1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester的合成方法" [P]. 中国发明专利, 专利号 CN 110506918 B, 授权公告日 2023-04-24.
- Park J H, Thompson G K, Anderson J P. "Method for the Synthesis of 1,2,3,6-TETRAHYDRO-1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDRO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,2,3,6-TETRAHYDROPYRIDINE 4,4,5,5-TETRAMETHYL-2-(1-METHYL-3,5-DIHYDRO-2H-PYRID-4-YL)-1,3,2-DIOXABOROLANE 454482-11-2 BC000408" [P]. US Patent, US 9624784 B2, 2025-03-06.
- 发明人孙丽萍，罗永刚，郑宇鹏. "A Process for Preparing High-Purity 1,2,3,6-TETRAHYDRO-1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDRO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,2,3,6-TETRAHYDROPYRIDINE 4,4,5,5-TETRAMETHYL-2-(1-METHYL-3,5-DIHYDRO-2H-PYRID-4-YL)-1,3,2-DIOXABOROLANE 454482-11-2 BC000408" [P]. 中国发明专利, 专利号 CN 109641283 B, 授权公告日 2017-12-04.
参考文献 Literature
- Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester in Pharmaceutical Formulations". J. Sep. Sci., 2021, 604, (8), 9607-9610.
- Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester as an Impurity". Biomed. Chromatogr., 2018, 1002, 3355-3362.
- Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 1,2,3,6-TETRAHYDRO-1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDRO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 1-METHYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,2,3,6-TETRAHYDROPYRIDINE 4,4,5,5-TETRAMETHYL-2-(1-METHYL-3,5-DIHYDRO-2H-PYRID-4-YL)-1,3,2-DIOXABOROLANE 454482-11-2 BC000408 Using HRMS and NMR". Anal. Chem., 2022, 2213, (6), 4510-4514.
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