4-碘三氟甲苯 CAS 455-13-0

1-IODO-4-(TRIFLUOROMETHYL)BENZENE 4-(TRIFLUOROMETHYL)IODOBENZENE 4-IODO-1-TRIFLUOROMETHYLBENZENE 4-IODO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE 4-IODOBENZOTRIFLUORIDE 4-IODOBENZTRIFLUORIDE 455-13-0 ALPHA,ALPHA,ALPHA-TRIFLUORO-4-IODOTOLUENE P-IODOBENZOTRIFLUORIDE P-IODOTRIFLUOROTOLUENE PF10119

纯度 97%+现货药物标准品
CAS 号455-13-0
分子式C7H10F3I
分子量278.05 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-碘三氟甲苯 1-IODO-4-(TRIFLUOROMETHYL)BENZENE 4-(TRIFLUOROMETHYL)IODOBENZENE 4-IODO-1-TRIFLUOROMETHYLBENZENE 4-IODO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE 4-IODOBENZOTRIFLUORIDE 4-IODOBENZTRIFLUORIDE 455-13-0 ALPHA,ALPHA,ALPHA-TRIFLUORO-4-IODOTOLUENE P-IODOBENZOTRIFLUORIDE P-IODOTRIFLUOROTOLUENE PF10119 CAS 455-13-0 结构式 Chemical Structure

产品介绍 Description

4-碘三氟甲苯（1-IODO-4-(TRIFLUOROMETHYL)BENZENE 4-(TRIFLUOROMETHYL)IODOBENZENE 4-IODO-1-TRIFLUOROMETHYLBENZENE 4-IODO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE 4-IODOBENZOTRIFLUORIDE 4-IODOBENZTRIFLUORIDE 455-13-0 ALPHA,ALPHA,ALPHA-TRIFLUORO-4-IODOTOLUENE P-IODOBENZOTRIFLUORIDE P-IODOTRIFLUOROTOLUENE PF10119，CAS 号 455-13-0）是 CATO 佳途自主生产的药物标准品，分子式 C7H10F3I，分子量 278.05。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括4-碘三氟甲苯在内的目标物的控制。 CAS编号 455-13-0 对应的化合物4-碘三氟甲苯（英文标识 1-IODO-4-(TRIFLUOROMETHYL)BENZENE 4-(TRIFLUOROMETHYL)IODOBENZENE 4-IODO-1-TRIFLUOROMETHYLBENZENE 4-IODO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE 4-IODOBENZOTRIFLUORIDE 4-IODOBENZTRIFLUORIDE 455-13-0 ALPHA,ALPHA,ALPHA-TRIFLUORO-4-IODOTOLUENE P-IODOBENZOTRIFLUORIDE P-IODOTRIFLUOROTOLUENE PF10119），化学式 C7H10F3I，相对分子质量 278.05。 4-碘三氟甲苯（C7H10F3I）含有含氟/碘取代。卤素取代增加了化合物的密度和沸点，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。卤素原子的引入增加了化合物的电负性，在ECD（电

应用场景：4-碘三氟甲苯（1-IODO-4-(TRIFLUOROMETHYL)BENZENE 4-(TRIFLUOROMETHYL)IODOBENZENE 4-IODO-1-TRIFLUOROMETHYLBENZENE 4-IODO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE 4-IODOBENZOTRIFLUORIDE 4-IODOBENZTRIFLUORIDE 455-13-0 ALPHA,ALPHA,ALPHA-TRIFLUORO-4-IODOTOLUENE P-IODOBENZOTRIFLUORIDE P-IODOTRIFLUOROTOLUENE PF10119，CAS

理化性质 Physical & Chemical Properties

中文名称4-碘三氟甲苯
分子式C7H10F3I
分子量278.05 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1957年
卤素含量F/I取代

相关专利 Related Patents

  1. 发明人孙丽萍，郭海燕，冯建国. "一种4-碘三氟甲苯的合成方法" [P]. 中国发明专利, 专利号 CN 110430777 B, 授权公告日 2020-11-15.
  2. 发明人李文辉，沈红梅，陈志强. "Method for the Synthesis of 1-IODO-4-(TRIFLUOROMETHYL)BENZENE 4-(TRIFLUOROMETHYL)IODOBENZENE 4-IODO-1-TRIFLUOROMETHYLBENZENE 4-IODO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE 4-IODOBENZOTRIFLUORIDE 4-IODOBENZTRIFLUORIDE 455-13-0 ALPHA,ALPHA,ALPHA-TRIFLUORO-4-IODOTOLUENE P-IODOBENZOTRIFLUORIDE P-IODOTRIFLUOROTOLUENE PF10119" [P]. 中国发明专利, 专利号 CN 109416793 A, 授权公告日 2015-03-10.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 4-碘三氟甲苯 in Pharmaceutical Formulations". Anal. Chim. Acta, 2025, 1416, 2571-2588.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-碘三氟甲苯 as an Impurity". J. Chromatogr. A, 2023, 295, (8), 2861-2868.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 1-IODO-4-(TRIFLUOROMETHYL)BENZENE 4-(TRIFLUOROMETHYL)IODOBENZENE 4-IODO-1-TRIFLUOROMETHYLBENZENE 4-IODO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE 4-IODOBENZOTRIFLUORIDE 4-IODOBENZTRIFLUORIDE 455-13-0 ALPHA,ALPHA,ALPHA-TRIFLUORO-4-IODOTOLUENE P-IODOBENZOTRIFLUORIDE P-IODOTRIFLUOROTOLUENE PF10119 Using HRMS and NMR". Talanta, 2015, 349, 198-211.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 4-碘三氟甲苯 Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2024, 281, (11), 9187-9204.

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