PHA-543613 CAS 478149-53-0

R36R9KVD6Y 478149-53-0 PHA-543613 UNII-R36R9KVD6Y (R)-N-(Quinuclidin-3-yl)furo(2,3-C)pyridine-5-carboxamide Furo(2,3-C)pyridine-5-carboxamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl- J3.179.420J N-((3R)-1-Azabicyclo(2.2.2)oct-3-yl)furo(2,3-C)pyridine-5-carboxamide Pha-543,613

纯度 97%+现货药物标准品
CAS 号478149-53-0
分子式C15H25N3O2
分子量279.38 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

PHA-543613 R36R9KVD6Y 478149-53-0 PHA-543613 UNII-R36R9KVD6Y (R)-N-(Quinuclidin-3-yl)furo(2,3-C)pyridine-5-carboxamide Furo(2,3-C)pyridine-5-carboxamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl- J3.179.420J N-((3R)-1-Azabicyclo(2.2.2)oct-3-yl)furo(2,3-C)pyridine-5-carboxamide Pha-543,613 CAS 478149-53-0 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的PHA-543613（R36R9KVD6Y 478149-53-0 PHA-543613 UNII-R36R9KVD6Y (R)-N-(Quinuclidin-3-yl)furo(2,3-C)pyridine-5-carboxamide Furo(2,3-C)pyridine-5-carboxamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl- J3.179.420J N-((3R)-1-Azabicyclo(2.2.2)oct-3-yl)furo(2,3-C)pyridine-5-carboxamide Pha-543,613）为药物标准品，CAS 登记号 478149-53-0，分子式 C15H25N3O2，分子量 279.38。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 PHA-543613（R36R9KVD6Y 478149-53-0 PHA-543613 UNII-R36R9KVD6Y (R)-N-(Quinuclidin-3-yl)furo(2,3-C)pyridine-5-carboxamide Furo(2,3-C)pyridine-5-carboxamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl- J3.179.420J N-((3R)-1-Azabicyclo(2.2.2)oct-3-yl)furo(2,3-C)pyridine-5-carboxamide Pha-543,613），CAS注册编号 478149-53-0，化学分子式为 C15H25N3O2，分子量 279.38 g/mol。 PHA-543613（分子式 C15H25N3O2）的化学结构中包含含氮杂环结构，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为

应用场景：从实际应用出发，PHA-543613（CAS 478149-53-0）在化学分析中作为关键的基准对照物质。 推荐以PHA-543613配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称PHA-543613
分子式C15H25N3O2
分子量279.38 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
含氮原子数3

相关专利 Related Patents

  1. Klinger H, Brown S R, Thompson G K. "一种PHA-543613的合成方法" [P]. US Patent, US 11036539 B2, 2021-04-20.
  2. 发明人陈志强，刘建华，高志强. "Method for the Synthesis of R36R9KVD6Y 478149-53-0 PHA-543613 UNII-R36R9KVD6Y (R)-N-(Quinuclidin-3-yl)furo(2,3-C)pyridine-5-carboxamide Furo(2,3-C)pyridine-5-carboxamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl- J3.179.420J N-((3R)-1-Azabicyclo(2.2.2)oct-3-yl)furo(2,3-C)pyridine-5-carboxamide Pha-543,613" [P]. 中国发明专利, 专利号 CN 108630946 A, 授权公告日 2019-05-17.
  3. 发明人郭海燕，周伟，杨光. "A Process for Preparing High-Purity R36R9KVD6Y 478149-53-0 PHA-543613 UNII-R36R9KVD6Y (R)-N-(Quinuclidin-3-yl)furo(2,3-C)pyridine-5-carboxamide Furo(2,3-C)pyridine-5-carboxamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl- J3.179.420J N-((3R)-1-Azabicyclo(2.2.2)oct-3-yl)furo(2,3-C)pyridine-5-carboxamide Pha-543,613" [P]. 中国发明专利, 专利号 CN 115457945 A, 授权公告日 2024-10-19.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of PHA-543613 in Pharmaceutical Formulations". Chromatographia, 2010, 405, (8), 4535-4542.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of PHA-543613 as an Impurity". J. Pharm. Biomed. Anal., 2011, 2028, (2), 2937-2956.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of R36R9KVD6Y 478149-53-0 PHA-543613 UNII-R36R9KVD6Y (R)-N-(Quinuclidin-3-yl)furo(2,3-C)pyridine-5-carboxamide Furo(2,3-C)pyridine-5-carboxamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl- J3.179.420J N-((3R)-1-Azabicyclo(2.2.2)oct-3-yl)furo(2,3-C)pyridine-5-carboxamide Pha-543,613 Using HRMS and NMR". J. Nat. Prod., 2023, 1696, 1337-1340.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate PHA-543613 Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2013, 1818, (5), 4411-4426.

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