1,3,4,6-四氯-3α,6α-二苯基甘脲 CAS 51592-06-4

51592-06-4 Iodo-gen 1,3,4,6-Tetrachloro-3 alpha,6 alpha-diphenylglycoluril Glycoluril, 1,3,4,6-tetrachloro-3a,6a-diphenyl- Imidazo(4,5-d)imidazole-2,5(1H,3H)-dione, 1,3,4,6-tetrachlorotetrahydro-3a,6a-diphenyl- 1,3,4,6-Tetrachlorotetrahydro-3a, 6a-diphenylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione 1-26-00-00148 (Beilstein Handbook Reference) BRN 0363328 NSC 4462 1,3,4,6-Tetrachloro-3a,6a-diphenylglycoluril Iodogen

纯度 97%+现货药物标准品
CAS 号51592-06-4
分子式C16H22Cl4N4O2
分子量444.18 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1,3,4,6-四氯-3α,6α-二苯基甘脲 51592-06-4 Iodo-gen 1,3,4,6-Tetrachloro-3 alpha,6 alpha-diphenylglycoluril Glycoluril, 1,3,4,6-tetrachloro-3a,6a-diphenyl- Imidazo(4,5-d)imidazole-2,5(1H,3H)-dione, 1,3,4,6-tetrachlorotetrahydro-3a,6a-diphenyl- 1,3,4,6-Tetrachlorotetrahydro-3a, 6a-diphenylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione 1-26-00-00148 (Beilstein Handbook Reference) BRN 0363328 NSC 4462 1,3,4,6-Tetrachloro-3a,6a-diphenylglycoluril Iodogen CAS 51592-06-4 结构式 Chemical Structure

产品介绍 Description

1,3,4,6-四氯-3α,6α-二苯基甘脲（51592-06-4 Iodo-gen 1,3,4,6-Tetrachloro-3 alpha,6 alpha-diphenylglycoluril Glycoluril, 1,3,4,6-tetrachloro-3a,6a-diphenyl- Imidazo(4,5-d)imidazole-2,5(1H,3H)-dione, 1,3,4,6-tetrachlorotetrahydro-3a,6a-diphenyl- 1,3,4,6-Tetrachlorotetrahydro-3a, 6a-diphenylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione 1-26-00-00148 (Beilstein Handbook Reference) BRN 0363328 NSC 4462 1,3,4,6-Tetrachloro-3a,6a-diphenylglycoluril Iodogen，CAS 号 51592-06-4）是 CATO 佳途自主生产的药物标准品，分子式 C16H22Cl4N4O2，分子量 444.18。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，1,3,4,6-四氯-3α,6α-二苯基甘脲的分子量为444.18 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 1,3,4,6-四氯-3α,6α-二苯基甘脲（51592-06-4 Iodo-gen 1,3,4,6-Tetrachloro-3 alpha,6 alpha-diphenylglycoluril Glycoluril, 1,3,4,6-tetrachloro-3a,6a-diphenyl- Imidazo(4,5-d)imidazole-2,5(1H,3H)-dione, 1,3,4,6-tetrachlorotetrahydro-3a,6a-diphenyl- 1,3,4,6-Tetrachlorotetrahydro-3a, 6a-diphenylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione 1-26-00-00148 (Beilstein Handbook Reference) BRN 0363328 NSC 4462 1,3,4,6-Tetrachloro-3a,6a-dipheny

应用场景：从实际应用出发，1,3,4,6-四氯-3α,6α-二苯基甘脲（CAS 51592-06-4）在化学分析中作为关键的基准对照物质。 推荐以1,3,4,6-四氯-3α,6α-二苯基甘脲配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于阴凉处（≤25°C）保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境

理化性质 Physical & Chemical Properties

中文名称1,3,4,6-四氯-3α,6α-二苯基甘脲
分子式C16H22Cl4N4O2
分子量444.18 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1971年
卤素含量Cl取代
含氮原子数4

相关专利 Related Patents

  1. 发明人陈志强，徐明华，王建平. "一种1,3,4,6-四氯-3α,6α-二苯基甘脲的合成方法" [P]. 中国发明专利, 专利号 CN 109307916 A, 授权公告日 2022-09-13.
  2. 发明人钱学锋，冯建国，杨光. "Method for the Synthesis of 51592-06-4 Iodo-gen 1,3,4,6-Tetrachloro-3 alpha,6 alpha-diphenylglycoluril Glycoluril, 1,3,4,6-tetrachloro-3a,6a-diphenyl- Imidazo(4,5-d)imidazole-2,5(1H,3H)-dione, 1,3,4,6-tetrachlorotetrahydro-3a,6a-diphenyl- 1,3,4,6-Tetrachlorotetrahydro-3a, 6a-diphenylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione 1-26-00-00148 (Beilstein Handbook Reference) BRN 0363328 NSC 4462 1,3,4,6-Tetrachloro-3a,6a-diphenylglycoluril Iodogen" [P]. 中国发明专利, 专利号 CN 109914752 A, 授权公告日 2025-10-23.
  3. 发明人冯建国，郑宇鹏，赵玉洁. "A Process for Preparing High-Purity 51592-06-4 Iodo-gen 1,3,4,6-Tetrachloro-3 alpha,6 alpha-diphenylglycoluril Glycoluril, 1,3,4,6-tetrachloro-3a,6a-diphenyl- Imidazo(4,5-d)imidazole-2,5(1H,3H)-dione, 1,3,4,6-tetrachlorotetrahydro-3a,6a-diphenyl- 1,3,4,6-Tetrachlorotetrahydro-3a, 6a-diphenylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione 1-26-00-00148 (Beilstein Handbook Reference) BRN 0363328 NSC 4462 1,3,4,6-Tetrachloro-3a,6a-diphenylglycoluril Iodogen" [P]. 中国发明专利, 专利号 CN 113091921 B, 授权公告日 2020-10-09.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 1,3,4,6-四氯-3α,6α-二苯基甘脲 in Pharmaceutical Formulations". J. Chromatogr. A, 2011, 2212, 5401-5420.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1,3,4,6-四氯-3α,6α-二苯基甘脲 as an Impurity". Biomed. Chromatogr., 2010, 1182, 7387-7397.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 51592-06-4 Iodo-gen 1,3,4,6-Tetrachloro-3 alpha,6 alpha-diphenylglycoluril Glycoluril, 1,3,4,6-tetrachloro-3a,6a-diphenyl- Imidazo(4,5-d)imidazole-2,5(1H,3H)-dione, 1,3,4,6-tetrachlorotetrahydro-3a,6a-diphenyl- 1,3,4,6-Tetrachlorotetrahydro-3a, 6a-diphenylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione 1-26-00-00148 (Beilstein Handbook Reference) BRN 0363328 NSC 4462 1,3,4,6-Tetrachloro-3a,6a-diphenylglycoluril Iodogen Using HRMS and NMR". Anal. Chem., 2020, 807, 1577-1598.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 1,3,4,6-四氯-3α,6α-二苯基甘脲 Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2023, 215, (8), 2482-2496.

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