2-氰基-3,3-二苯基丙烯酸乙酯 CAS 5232-99-5
974109G71I 5232-99-5 Ethyl 2-cyano-3,3-diphenylacrylate Ethyl 2-cyano-3,3-diphenyl-2-propenoate Etocrylene Etocrylene [USAN] 2-Propenoic acid, 2-cyano-3,3-diphenyl-, ethyl ester UV absorber-2 Etocrilene [INN] Acrylic acid, 2-cyano-3,3-diphenyl-, ethyl ester (8CI) Acrylonitrile, 3,3-dicyclopropyl-2-(ethoxycarbonyl)- Etocrilene 4-09-00-03640 (Beilstein Handbook Reference) Acrylonitrile, beta, beta-biscyclopropyl-,alpha-carbethoxy- Acrylonitrile, beta,beta-biscyclopropyl-alpha-carbethoxy- BRN 1885803 alpha-Carbethoxy-beta,beta-biscyclopropyl acrylonitrile CE 2 alpha-Cyano-beta-phenylcinnamic acid, ethyl ester EINECS 226-029-0 Ethyl alpha-cyan-beta,beta-diphenylacrylate Ethyl alpha-cyano-beta,beta-diphenylacrylate Ethyl (diphenylmethylene)cyanoacetate Etocrileno [INN-Spanish] Etocrilenum [INN-Latin] NSC 52678 USAF A-15972 Uvinul N 35 HSDB 7218 Etocrileno Etocrilenum UNII-974109G71I EC 226-029-0
| CAS 号 | 5232-99-5 |
| 分子式 | C18H27NO2 |
| 分子量 | 289.41 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 5232-99-5 对应的2-氰基-3,3-二苯基丙烯酸乙酯（974109G71I 5232-99-5 Ethyl 2-cyano-3,3-diphenylacrylate Ethyl 2-cyano-3,3-diphenyl-2-propenoate Etocrylene Etocrylene [USAN] 2-Propenoic acid, 2-cyano-3,3-diphenyl-, ethyl ester UV absorber-2 Etocrilene [INN] Acrylic acid, 2-cyano-3,3-diphenyl-, ethyl ester (8CI) Acrylonitrile, 3,3-dicyclopropyl-2-(ethoxycarbonyl)- Etocrilene 4-09-00-03640 (Beilstein Handbook Reference) Acrylonitrile, beta, beta-biscyclopropyl-,alpha-carbethoxy- Acrylonitrile, beta,beta-biscyclopropyl-alpha-carbethoxy- BRN 1885803 alpha-Carbethoxy-beta,beta-biscyclopropyl acrylonitrile CE 2 alpha-Cyano-beta-phenylcinnamic acid, ethyl ester EINECS 226-029-0 Ethyl alpha-cyan-beta,beta-diphenylacrylate Ethyl alpha-cyano-beta,beta-diphenylacrylate Ethyl (diphenylmethylene)cyanoacetate Etocrileno [INN-Spanish] Etocrilenum [INN-Latin] NSC 52678 USAF A-15972 Uvinul N 35 HSDB 7218 Etocrileno Etocrilenum UNII-974109G71I EC 226-029-0）为 CATO 佳途药物标准品产品线成员。分子式 C18H27NO2，分子量 289.41。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括2-氰基-3,3-二苯基丙烯酸乙酯在内的目标物的控制。 CAS编号 5232-99-5 对应的化合物2-氰基-3,3-二苯基丙烯酸乙酯（英文标识 974109G71I 5232-99-5 Ethyl 2-cyano-3,3-diphenylacrylate Ethyl 2-cyano-3,3-diphenyl-2-propenoate Etocrylene Etocrylene USAN 2-Propenoic acid, 2-cyano-3,3-diphenyl-, ethyl ester UV absorber-2 Etocrilene INN Acrylic acid, 2-cyano-3,3-diphenyl-, ethyl ester (8CI) Acrylonitrile, 3,3-dicyclopropyl-2-(ethoxycarbonyl)- Etocrilene 4-09-00-03640 (Beilstein Handbook Reference) Acrylonitrile, beta, be
应用场景：2-氰基-3,3-二苯基丙烯酸乙酯（974109G71I 5232-99-5 Ethyl 2-cyano-3,3-diphenylacrylate Ethyl 2-cyano-3,3-diphenyl-2-propenoate Etocrylene Etocrylene USAN 2-Propenoic acid, 2-cyano-3,3-diphenyl-, ethyl ester UV absorber-2 Etocrilene INN Acrylic acid, 2-cyano-3,3-diphenyl-, ethyl ester (8CI) Acrylonitrile, 3,3
理化性质 Physical & Chemical Properties
| 中文名称 | 2-氰基-3,3-二苯基丙烯酸乙酯 |
| 分子式 | C18H27NO2 |
| 分子量 | 289.41 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 6.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1958年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人张德明，王建平，沈红梅. "一种2-氰基-3,3-二苯基丙烯酸乙酯的合成方法" [P]. 中国发明专利, 专利号 CN 112818203 A, 授权公告日 2020-07-08.
- 发明人郑宇鹏，陈志强，胡光. "Method for the Synthesis of 974109G71I 5232-99-5 Ethyl 2-cyano-3,3-diphenylacrylate Ethyl 2-cyano-3,3-diphenyl-2-propenoate Etocrylene Etocrylene [USAN] 2-Propenoic acid, 2-cyano-3,3-diphenyl-, ethyl ester UV absorber-2 Etocrilene [INN] Acrylic acid, 2-cyano-3,3-diphenyl-, ethyl ester (8CI) Acrylonitrile, 3,3-dicyclopropyl-2-(ethoxycarbonyl)- Etocrilene 4-09-00-03640 (Beilstein Handbook Reference) Acrylonitrile, beta, beta-biscyclopropyl-,alpha-carbethoxy- Acrylonitrile, beta,beta-biscyclopropyl-alpha-carbethoxy- BRN 1885803 alpha-Carbethoxy-beta,beta-biscyclopropyl acrylonitrile CE 2 alpha-Cyano-beta-phenylcinnamic acid, ethyl ester EINECS 226-029-0 Ethyl alpha-cyan-beta,beta-diphenylacrylate Ethyl alpha-cyano-beta,beta-diphenylacrylate Ethyl (diphenylmethylene)cyanoacetate Etocrileno [INN-Spanish] Etocrilenum [INN-Latin] NSC 52678 USAF A-15972 Uvinul N 35 HSDB 7218 Etocrileno Etocrilenum UNII-974109G71I EC 226-029-0" [P]. 中国发明专利, 专利号 CN 109222636 A, 授权公告日 2022-02-28.
- 发明人何建平，孙丽萍，高志强. "A Process for Preparing High-Purity 974109G71I 5232-99-5 Ethyl 2-cyano-3,3-diphenylacrylate Ethyl 2-cyano-3,3-diphenyl-2-propenoate Etocrylene Etocrylene [USAN] 2-Propenoic acid, 2-cyano-3,3-diphenyl-, ethyl ester UV absorber-2 Etocrilene [INN] Acrylic acid, 2-cyano-3,3-diphenyl-, ethyl ester (8CI) Acrylonitrile, 3,3-dicyclopropyl-2-(ethoxycarbonyl)- Etocrilene 4-09-00-03640 (Beilstein Handbook Reference) Acrylonitrile, beta, beta-biscyclopropyl-,alpha-carbethoxy- Acrylonitrile, beta,beta-biscyclopropyl-alpha-carbethoxy- BRN 1885803 alpha-Carbethoxy-beta,beta-biscyclopropyl acrylonitrile CE 2 alpha-Cyano-beta-phenylcinnamic acid, ethyl ester EINECS 226-029-0 Ethyl alpha-cyan-beta,beta-diphenylacrylate Ethyl alpha-cyano-beta,beta-diphenylacrylate Ethyl (diphenylmethylene)cyanoacetate Etocrileno [INN-Spanish] Etocrilenum [INN-Latin] NSC 52678 USAF A-15972 Uvinul N 35 HSDB 7218 Etocrileno Etocrilenum UNII-974109G71I EC 226-029-0" [P]. 中国发明专利, 专利号 CN 109044161 B, 授权公告日 2022-11-26.
参考文献 Literature
- Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 2-氰基-3,3-二苯基丙烯酸乙酯 in Pharmaceutical Formulations". Anal. Methods, 2015, 1780, (7), 2983-3004.
- Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-氰基-3,3-二苯基丙烯酸乙酯 as an Impurity". Talanta, 2021, 1971, (6), 8872-8891.
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