1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro[cyclopentane-1,2-furo[3,4-d][1,3]dioxol]-6-yl)pyrimidine-2,4(1H,3H)-dione CAS 5297-71-2

1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro[cyclopentane-1,2-furo[3,4-d][1,3]dioxol]-6-yl)pyrimidine-2,4(1H,3H)-dione

纯度 97%+现货药物标准品
CAS 号5297-71-2
分子式C14H18N2O6
分子量310.30 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro[cyclopentane-1,2-furo[3,4-d][1,3]dioxol]-6-yl)pyrimidine-2,4(1H,3H)-dione 1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro[cyclopentane-1,2-furo[3,4-d][1,3]dioxol]-6-yl)pyrimidine-2,4(1H,3H)-dione CAS 5297-71-2 结构式 Chemical Structure

产品介绍 Description

1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro[cyclopentane-1,2-furo[3,4-d][1,3]dioxol]-6-yl)pyrimidine-2,4(1H,3H)-dione（1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro[cyclopentane-1,2-furo[3,4-d][1,3]dioxol]-6-yl)pyrimidine-2,4(1H,3H)-dione）是药物分析与质量控制领域常用的药物标准品，CAS 号 5297-71-2。分子式 C14H18N2O6，分子量 310.30。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospirocyclopentane-1,2-furo3,4-d1,3dioxol-6-yl)pyrimidine-2,4(1H,3H)-dione在内的目标物的控制。 1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospirocyclopentane-1,2-furo3,4-d1,3dioxol-6-yl)pyrimidine-2,4(1H,3H)-dione（1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospirocyclopentane-1,2-furo3,4-d1,3dioxol-6-yl)pyrimidine-2,4(1H,3H)-dione），CAS注册编号 5297-71-2，化学分子式为 C14H18N2O6，分子量 310.30 g/mol。 依据分子式为 C14H18N2O6 的1-((3a

应用场景：在化学分析实验室中，1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro cyclopentane-1,2-furo 3,4-d 1,3 dioxol -6-yl)pyrimidine-2,4(1H,3H)-dione（CAS 5297-71-2）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro cyclopentane-1,2-furo 3,4-d 1,3 dioxol -6-yl)pyrimidine-2,4(1H,

理化性质 Physical & Chemical Properties

中文名称1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro[cyclopentane-1,2-furo[3,4-d][1,3]dioxol]-6-yl)pyrimidine-2,4(1H,3H)-dione
分子式C14H18N2O6
分子量310.30 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1958年
含氮原子数2

相关专利 Related Patents

  1. Davis P L, Fischer A B, Park J H. "一种1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro[cyclopentane-1,2-furo[3,4-d][1,3]dioxol]-6-yl)pyrimidine-2,4(1H,3H)-dione的合成方法" [P]. US Patent, US 11345499 B2, 2018-05-07.
  2. 发明人徐明华，胡光，刘建华. "Method for the Synthesis of 1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro[cyclopentane-1,2-furo[3,4-d][1,3]dioxol]-6-yl)pyrimidine-2,4(1H,3H)-dione" [P]. 中国发明专利, 专利号 CN 109864353 A, 授权公告日 2016-03-05.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro[cyclopentane-1,2-furo[3,4-d][1,3]dioxol]-6-yl)pyrimidine-2,4(1H,3H)-dione in Pharmaceutical Formulations". J. Sep. Sci., 2017, 2434, (11), 5421-5442.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro[cyclopentane-1,2-furo[3,4-d][1,3]dioxol]-6-yl)pyrimidine-2,4(1H,3H)-dione as an Impurity". J. Agric. Food Chem., 2016, 2453, (3), 938-948.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of 1-((3aR,4R,6R,6aR)-4-(hydroxymethyl)tetrahydrospiro[cyclopentane-1,2-furo[3,4-d][1,3]dioxol]-6-yl)pyrimidine-2,4(1H,3H)-dione Using HRMS and NMR". Talanta, 2018, 365, (11), 544-550.

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