CAS 536748-46-6

536748-46-6 5FCH6YDY7Z N-(4-Chlorophenyl)-N-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidiine-1,2-dicarboxamide Eribaxaban [USAN:INN] 1,2-Pyrrolidinedicarboxamide, N1-(4-chlorophenyl)-N2-(2-fluoro-4-(2-oxo-1(2H)- pyridinyl)phenyl)-4-methoxy-, (2R,4R)- Eribaxaban (2R,4R)-N1-(4-Chlorophenyl)-N2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide PD 348,292 PD 348292 PD0348292 PD 0348292 PD-0348292 UNII-5FCH6YDY7Z

纯度 97%+现货药物标准品
CAS 号536748-46-6
分子式C24H22ClFN4O4
分子量484.91 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

536748-46-6 5FCH6YDY7Z N-(4-Chlorophenyl)-N-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidiine-1,2-dicarboxamide Eribaxaban [USAN:INN] 1,2-Pyrrolidinedicarboxamide, N1-(4-chlorophenyl)-N2-(2-fluoro-4-(2-oxo-1(2H)- pyridinyl)phenyl)-4-methoxy-, (2R,4R)- Eribaxaban (2R,4R)-N1-(4-Chlorophenyl)-N2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide PD 348,292 PD 348292 PD0348292 PD 0348292 PD-0348292 UNII-5FCH6YDY7Z CAS 536748-46-6 结构式 Chemical Structure

产品介绍 Description

CAS 536748-46-6 对应的（536748-46-6 5FCH6YDY7Z N-(4-Chlorophenyl)-N-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidiine-1,2-dicarboxamide Eribaxaban [USAN:INN] 1,2-Pyrrolidinedicarboxamide, N1-(4-chlorophenyl)-N2-(2-fluoro-4-(2-oxo-1(2H)- pyridinyl)phenyl)-4-methoxy-, (2R,4R)- Eribaxaban (2R,4R)-N1-(4-Chlorophenyl)-N2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide PD 348,292 PD 348292 PD0348292 PD 0348292 PD-0348292 UNII-5FCH6YDY7Z）为 CATO 佳途药物标准品产品线成员。分子式 C24H22ClFN4O4，分子量 484.91。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，的分子量为484.91 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 （536748-46-6 5FCH6YDY7Z N-(4-Chlorophenyl)-N-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidiine-1,2-dicarboxamide Eribaxaban USAN:INN 1,2-Pyrrolidinedicarboxamide, N1-(4-chlorophenyl)-N2-(2-fluoro-4-(2-oxo-1(2H)- pyridinyl)phenyl)-4-methoxy-, (2R,4R)- Eribaxaban (2R,4R)-N1-(4-Chlorophenyl)-N2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide PD 348,292 PD 348292 PD0348292 PD 0348292 PD-0348

应用场景：（536748-46-6 5FCH6YDY7Z N-(4-Chlorophenyl)-N-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidiine-1,2-dicarboxamide Eribaxaban USAN:INN 1,2-Pyrrolidinedicarboxamide, N1-(4-chlorophenyl)-N2-(2-fluoro-4-(2-oxo-1(2H)- pyridinyl)phenyl)-4-methoxy-, (2R,4R)- Eribaxaban (2R,4R)-N1-(4-Chlorop

理化性质 Physical & Chemical Properties

中文名称
分子式C24H22ClFN4O4
分子量484.91 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）15.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1984年
卤素含量F/Cl取代
含氮原子数4

相关专利 Related Patents

  1. 发明人杨光，张德明，刘建华. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 108300110 B, 授权公告日 2025-06-05.
  2. Anderson J P, Stevens L M, Klinger H. "Method for the Synthesis of 536748-46-6 5FCH6YDY7Z N-(4-Chlorophenyl)-N-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidiine-1,2-dicarboxamide Eribaxaban [USAN:INN] 1,2-Pyrrolidinedicarboxamide, N1-(4-chlorophenyl)-N2-(2-fluoro-4-(2-oxo-1(2H)- pyridinyl)phenyl)-4-methoxy-, (2R,4R)- Eribaxaban (2R,4R)-N1-(4-Chlorophenyl)-N2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide PD 348,292 PD 348292 PD0348292 PD 0348292 PD-0348292 UNII-5FCH6YDY7Z" [P]. US Patent, US 11445784 B2, 2024-01-11.
  3. 发明人周伟，赵玉洁，黄志刚. "A Process for Preparing High-Purity 536748-46-6 5FCH6YDY7Z N-(4-Chlorophenyl)-N-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidiine-1,2-dicarboxamide Eribaxaban [USAN:INN] 1,2-Pyrrolidinedicarboxamide, N1-(4-chlorophenyl)-N2-(2-fluoro-4-(2-oxo-1(2H)- pyridinyl)phenyl)-4-methoxy-, (2R,4R)- Eribaxaban (2R,4R)-N1-(4-Chlorophenyl)-N2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide PD 348,292 PD 348292 PD0348292 PD 0348292 PD-0348292 UNII-5FCH6YDY7Z" [P]. 中国发明专利, 专利号 CN 112942839 A, 授权公告日 2019-10-09.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Agric. Food Chem., 2021, 1075, (6), 7516-7542.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". J. Sep. Sci., 2025, 2362, (11), 8279-8282.

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