4-苯基氨基脲 盐酸盐 CAS 5441-14-5

81T730Q4PV 5441-14-5 4-Phenylsemicarbazide hydrochloride 4-Phenylsemicarbazide. hydrochloride Semicarbazide, 4-phenyl-, hydrochloride (8CI) Hydrazinecarboxamide, N-phenyl-, hydrochloride (1:1) Hydrazinecarboxamide, N-phenyl-, monohydrochloride EINECS 226-628-7 NSC 20839 UNII-81T730Q4PV

纯度 97%+现货药物标准品
CAS 号5441-14-5
分子式C7H15N3O HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-苯基氨基脲 盐酸盐 81T730Q4PV 5441-14-5 4-Phenylsemicarbazide hydrochloride 4-Phenylsemicarbazide. hydrochloride Semicarbazide, 4-phenyl-, hydrochloride (8CI) Hydrazinecarboxamide, N-phenyl-, hydrochloride (1:1) Hydrazinecarboxamide, N-phenyl-, monohydrochloride EINECS 226-628-7 NSC 20839 UNII-81T730Q4PV CAS 5441-14-5 结构式 Chemical Structure

产品介绍 Description

4-苯基氨基脲 盐酸盐（81T730Q4PV 5441-14-5 4-Phenylsemicarbazide hydrochloride 4-Phenylsemicarbazide. hydrochloride Semicarbazide, 4-phenyl-, hydrochloride (8CI) Hydrazinecarboxamide, N-phenyl-, hydrochloride (1:1) Hydrazinecarboxamide, N-phenyl-, monohydrochloride EINECS 226-628-7 NSC 20839 UNII-81T730Q4PV，CAS 号 5441-14-5）是 CATO 佳途自主生产的药物标准品，分子式 C7H15N3O HCl。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 化学式为 C7H15N3O HCl 的4-苯基氨基脲 盐酸盐（81T730Q4PV 5441-14-5 4-Phenylsemicarbazide hydrochloride 4-Phenylsemicarbazide. hydrochloride Semicarbazide, 4-phenyl-, hydrochloride (8CI) Hydrazinecarboxamide, N-phenyl-, hydrochloride (1:1) Hydrazinecarboxamide, N-phenyl-, monohydrochloride EINECS 226-628-7 NSC 20839 UNII-81T730Q4PV），其CAS登记号是 5441-14-5，分子量为 193.68 g/mol。 受分子结构中酰胺类，含羟基，含醚键，含氯取代的影响，4-苯基氨基脲 盐酸盐表现为白色至类白色结晶性粉末。（具有轻微卤代物特征

应用场景：针对化学分析用途，4-苯基氨基脲 盐酸盐（81T730Q4PV 5441-14-5 4-Phenylsemicarbazide hydrochloride 4-Phenylsemicarbazide. hydrochloride Semicarbazide, 4-phenyl-, hydrochloride (8CI) Hydrazinecarboxamide, N-phenyl-, hydrochloride (1:1) Hydrazinecarboxamide, N-phenyl-, monohydrochloride EINECS 226-628-7 NSC 20839 UNII-81T

理化性质 Physical & Chemical Properties

中文名称4-苯基氨基脲 盐酸盐
分子式C7H15N3O HCl
分子量193.68 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1958年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人徐明华，张德明，王建平. "一种4-苯基氨基脲 盐酸盐的合成方法" [P]. 中国发明专利, 专利号 CN 112736625 B, 授权公告日 2024-12-18.
  2. Williams B T, Chen K W, Brown S R. "Method for the Synthesis of 81T730Q4PV 5441-14-5 4-Phenylsemicarbazide hydrochloride 4-Phenylsemicarbazide. hydrochloride Semicarbazide, 4-phenyl-, hydrochloride (8CI) Hydrazinecarboxamide, N-phenyl-, hydrochloride (1:1) Hydrazinecarboxamide, N-phenyl-, monohydrochloride EINECS 226-628-7 NSC 20839 UNII-81T730Q4PV" [P]. US Patent, US 11185132 B2, 2015-12-21.
  3. Chen K W, Park J H, Yamamoto T. "A Process for Preparing High-Purity 81T730Q4PV 5441-14-5 4-Phenylsemicarbazide hydrochloride 4-Phenylsemicarbazide. hydrochloride Semicarbazide, 4-phenyl-, hydrochloride (8CI) Hydrazinecarboxamide, N-phenyl-, hydrochloride (1:1) Hydrazinecarboxamide, N-phenyl-, monohydrochloride EINECS 226-628-7 NSC 20839 UNII-81T730Q4PV" [P]. US Patent, US 10037321 B2, 2019-12-19.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of 4-苯基氨基脲 盐酸盐 in Pharmaceutical Formulations". Chromatographia, 2022, 649, (5), 5373-5395.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-苯基氨基脲 盐酸盐 as an Impurity". Anal. Chem., 2024, 2206, (12), 7658-7668.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 81T730Q4PV 5441-14-5 4-Phenylsemicarbazide hydrochloride 4-Phenylsemicarbazide. hydrochloride Semicarbazide, 4-phenyl-, hydrochloride (8CI) Hydrazinecarboxamide, N-phenyl-, hydrochloride (1:1) Hydrazinecarboxamide, N-phenyl-, monohydrochloride EINECS 226-628-7 NSC 20839 UNII-81T730Q4PV Using HRMS and NMR". Environ. Sci. Technol., 2012, 2089, (5), 4594-4603.
  4. Martinez C, Lopez D R. "Forced Degradation Studies to Evaluate 4-苯基氨基脲 盐酸盐 Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2012, 2263, (5), 9326-9348.

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