Skullcapflavone II CAS 55084-08-7

5,2'-dihydroxy-6,7,8,6'-tetramethoxyflavone 5-hydroxy-2-(2-hydroxy-6-methoxy-phenyl)-6,7,8-trimethoxy-chromen-4-one 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one 55084-08-7 CHEBI:9061 neobaicalein scullcapflavone II skullcapflavone II

纯度 97%+现货药物标准品
CAS 号55084-08-7
分子式C19H18O8
分子量374.34 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Skullcapflavone II 5,2'-dihydroxy-6,7,8,6'-tetramethoxyflavone 5-hydroxy-2-(2-hydroxy-6-methoxy-phenyl)-6,7,8-trimethoxy-chromen-4-one 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one 55084-08-7 CHEBI:9061 neobaicalein scullcapflavone II skullcapflavone II CAS 55084-08-7 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品Skullcapflavone II（5,2'-dihydroxy-6,7,8,6'-tetramethoxyflavone 5-hydroxy-2-(2-hydroxy-6-methoxy-phenyl)-6,7,8-trimethoxy-chromen-4-one 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one 55084-08-7 CHEBI:9061 neobaicalein scullcapflavone II skullcapflavone II，CAS 55084-08-7），分子式 C19H18O8，分子量 374.34。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

作为认证标准物质（CRM），Skullcapflavone II满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C19H18O8 的Skullcapflavone II（5,2'-dihydroxy-6,7,8,6'-tetramethoxyflavone 5-hydroxy-2-(2-hydroxy-6-methoxy-phenyl)-6,7,8-trimethoxy-chromen-4-one 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one 55084-08-7 CHEBI:9061 neobaicalein scullcapflavone II skullcapflavone II），其CAS登记号是 55084-08-7，分子量为 374.34 g/mol。 受分子结构中黄酮骨架，含羟基，含醚键的影响，Skullca

应用场景：Skullcapflavone II（5,2'-dihydroxy-6,7,8,6'-tetramethoxyflavone 5-hydroxy-2-(2-hydroxy-6-methoxy-phenyl)-6,7,8-trimethoxy-chromen-4-one 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one 55084-08-7 CHEBI:9061 neobaicalein scullcapflavone II skullcapflavone II，CAS 55084-08-

理化性质 Physical & Chemical Properties

中文名称Skullcapflavone II
分子式C19H18O8
分子量374.34 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1972年

相关专利 Related Patents

  1. Nielsen H, Mueller T C, Schröder R. "一种Skullcapflavone II的合成方法" [P]. European Patent, EP 3667465 A1, 2025-02-07.
  2. 发明人张德明，刘建华，唐晓军. "Method for the Synthesis of 5,2'-dihydroxy-6,7,8,6'-tetramethoxyflavone 5-hydroxy-2-(2-hydroxy-6-methoxy-phenyl)-6,7,8-trimethoxy-chromen-4-one 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one 55084-08-7 CHEBI:9061 neobaicalein scullcapflavone II skullcapflavone II" [P]. 中国发明专利, 专利号 CN 114946466 A, 授权公告日 2024-10-09.
  3. 发明人朱建伟，孙丽萍，郑宇鹏. "A Process for Preparing High-Purity 5,2'-dihydroxy-6,7,8,6'-tetramethoxyflavone 5-hydroxy-2-(2-hydroxy-6-methoxy-phenyl)-6,7,8-trimethoxy-chromen-4-one 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one 55084-08-7 CHEBI:9061 neobaicalein scullcapflavone II skullcapflavone II" [P]. 中国发明专利, 专利号 CN 115642204 B, 授权公告日 2016-09-02.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of Skullcapflavone II in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2019, 2399, (3), 2620-2632.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of Skullcapflavone II as an Impurity". Biomed. Chromatogr., 2017, 2245, 8724-8735.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of 5,2'-dihydroxy-6,7,8,6'-tetramethoxyflavone 5-hydroxy-2-(2-hydroxy-6-methoxy-phenyl)-6,7,8-trimethoxy-chromen-4-one 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one 55084-08-7 CHEBI:9061 neobaicalein scullcapflavone II skullcapflavone II Using HRMS and NMR". Chemosphere, 2018, 295, (7), 620-649.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate Skullcapflavone II Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2020, 1612, (9), 5628-5631.

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