Boc-β<SUP>3</SUP>-Homopro-OH CAS 56502-01-3

(S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinyl]acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]ethanoic acid 2-[(2S)-1-tert-butoxycarbonylpyrrolidin-2-yl]acetic acid 56502-01-3

纯度 97%+现货药物标准品
CAS 号56502-01-3
分子式C11H19NO4
分子量229.27 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Boc-β<SUP>3</SUP>-Homopro-OH (S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinyl]acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]ethanoic acid 2-[(2S)-1-tert-butoxycarbonylpyrrolidin-2-yl]acetic acid 56502-01-3 CAS 56502-01-3 结构式 Chemical Structure

产品介绍 Description

Boc-β<SUP>3</SUP>-Homopro-OH（英文名 (S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinyl]acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]ethanoic acid 2-[(2S)-1-tert-butoxycarbonylpyrrolidin-2-yl]acetic acid 56502-01-3，CAS 56502-01-3）属于药物标准品。分子式 C11H19NO4，分子量 229.27。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，Boc-β<SUP>3</SUP>-Homopro-OH的分子量为229.27 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 Boc-β<SUP>3</SUP>-Homopro-OH（(S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid 2-(2S)-1-(2-methylpropan-2-yl)oxy-oxomethyl-2-pyrrolidinylacetic acid 2-(2S)-1-(2-methylpropan-2-yl)oxycarbonylpyrrolidin-2-ylacetic acid 2-(2S)-1-(2-methylpropan-2-yl)oxycarbonylpyrrolidin-2-ylethanoic acid 2-(2S)-1-tert-butoxycarbonylpyrrolidin-2-ylacetic acid 56502-01-3），CAS注册编号 56502-01-3，化学分子式为 C11H19NO4，分

应用场景：针对化学分析用途，Boc-β<SUP>3</SUP>-Homopro-OH（(S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid 2- (2S)-1- (2-methylpropan-2-yl)oxy-oxomethyl -2-pyrrolidinyl acetic acid 2- (2S)-1- (2-methylpropan-2-yl)oxycarbonyl pyrrolidin-2-yl acetic acid 2- (2S)-1- (2-methylpropan-2-yl)oxycarbonyl pyrrolidin-2-y

理化性质 Physical & Chemical Properties

中文名称Boc-β<SUP>3</SUP>-Homopro-OH
分子式C11H19NO4
分子量229.27 g/mol
外观形态白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1973年
含氮原子数1

相关专利 Related Patents

  1. Williams B T, Chen K W, Anderson J P. "一种Boc-β<SUP>3</SUP>-Homopro-OH的合成方法" [P]. US Patent, US 11160638 B2, 2016-03-04.
  2. 发明人马晓峰，李文辉，徐明华. "Method for the Synthesis of (S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinyl]acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]ethanoic acid 2-[(2S)-1-tert-butoxycarbonylpyrrolidin-2-yl]acetic acid 56502-01-3" [P]. 中国发明专利, 专利号 CN 110150065 B, 授权公告日 2020-08-08.
  3. Mueller T, Davis P L, Park J H. "A Process for Preparing High-Purity (S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinyl]acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]ethanoic acid 2-[(2S)-1-tert-butoxycarbonylpyrrolidin-2-yl]acetic acid 56502-01-3" [P]. US Patent, US 10081378 B2, 2024-09-20.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of Boc-β<SUP>3</SUP>-Homopro-OH in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2019, 1990, (11), 4252-4272.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of Boc-β<SUP>3</SUP>-Homopro-OH as an Impurity". Rapid Commun. Mass Spectrom., 2018, 2074, (9), 5211-5226.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of (S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinyl]acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]acetic acid 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]ethanoic acid 2-[(2S)-1-tert-butoxycarbonylpyrrolidin-2-yl]acetic acid 56502-01-3 Using HRMS and NMR". J. Agric. Food Chem., 2021, 2259, (8), 876-906.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate Boc-β<SUP>3</SUP>-Homopro-OH Profile in Drug Substances According to ICH Guidelines". Molecules, 2022, 1287, (12), 5421-5436.

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