MTT 甲臜 CAS 57360-69-7

(NE,E)-N-[(dimethyl-1,3-thiazol-2-yl)imino]-N'-(phenylamino)benzene-1-carboximidamide 1-(4,5-Dimethylthiazol-2-yl)-3,5-diphenylformazan 57360-69-7 N-[(dimethyl-1,3-thiazol-2-yl)imino]-N'-(phenylamino)benzenecarboximidamide Thiazolyl blue formazan

纯度 97%+现货药物标准品
CAS 号57360-69-7
分子式C18H33N5S
分子量351.55 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

MTT 甲臜 (NE,E)-N-[(dimethyl-1,3-thiazol-2-yl)imino]-N'-(phenylamino)benzene-1-carboximidamide 1-(4,5-Dimethylthiazol-2-yl)-3,5-diphenylformazan 57360-69-7 N-[(dimethyl-1,3-thiazol-2-yl)imino]-N'-(phenylamino)benzenecarboximidamide Thiazolyl blue formazan CAS 57360-69-7 结构式 Chemical Structure

产品介绍 Description

CAS 57360-69-7 对应的MTT 甲臜（(NE,E)-N-[(dimethyl-1,3-thiazol-2-yl)imino]-N'-(phenylamino)benzene-1-carboximidamide 1-(4,5-Dimethylthiazol-2-yl)-3,5-diphenylformazan 57360-69-7 N-[(dimethyl-1,3-thiazol-2-yl)imino]-N'-(phenylamino)benzenecarboximidamide Thiazolyl blue formazan）为 CATO 佳途药物标准品产品线成员。分子式 C18H33N5S，分子量 351.55。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，MTT 甲臜的分子量为351.55 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 57360-69-7 对应的化合物MTT 甲臜（英文标识 (NE,E)-N-(dimethyl-1,3-thiazol-2-yl)imino-N'-(phenylamino)benzene-1-carboximidamide 1-(4,5-Dimethylthiazol-2-yl)-3,5-diphenylformazan 57360-69-7 N-(dimethyl-1,3-thiazol-2-yl)imino-N'-(phenylamino)benzenecarboximidamide Thiazolyl blue formazan），化学式 C18H33N5S，相对分子质量 351.55。 MTT 甲臜（分子式 C18H33N5S）的化学结构中包含含氮杂环结构，含氰基，含硫有机。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。分子中的氮原子赋予该化合物一

应用场景：针对化学分析用途，MTT 甲臜（(NE,E)-N- (dimethyl-1,3-thiazol-2-yl)imino -N'-(phenylamino)benzene-1-carboximidamide 1-(4,5-Dimethylthiazol-2-yl)-3,5-diphenylformazan 57360-69-7 N- (dimethyl-1,3-thiazol-2-yl)imino -N'-(phenylamino)benzenecarboximidamide Thiazolyl blue formazan）是具有明确定量溯源的认证级对照品。 推荐以MTT 甲臜配制标准系列工作溶

理化性质 Physical & Chemical Properties

中文名称MTT 甲臜
分子式C18H33N5S
分子量351.55 g/mol
外观形态类白色至淡黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1973年
含氮原子数5
含硫原子数1

相关专利 Related Patents

  1. Johansson L, Schröder R, Mueller T C. "一种MTT 甲臜的合成方法" [P]. European Patent, EP 3974565 A1, 2025-11-28.
  2. 发明人马晓峰，何建平，郭海燕. "Method for the Synthesis of (NE,E)-N-[(dimethyl-1,3-thiazol-2-yl)imino]-N'-(phenylamino)benzene-1-carboximidamide 1-(4,5-Dimethylthiazol-2-yl)-3,5-diphenylformazan 57360-69-7 N-[(dimethyl-1,3-thiazol-2-yl)imino]-N'-(phenylamino)benzenecarboximidamide Thiazolyl blue formazan" [P]. 中国发明专利, 专利号 CN 110374701 A, 授权公告日 2019-01-19.
  3. Patel M V, Kumar R, Stevens L M. "A Process for Preparing High-Purity (NE,E)-N-[(dimethyl-1,3-thiazol-2-yl)imino]-N'-(phenylamino)benzene-1-carboximidamide 1-(4,5-Dimethylthiazol-2-yl)-3,5-diphenylformazan 57360-69-7 N-[(dimethyl-1,3-thiazol-2-yl)imino]-N'-(phenylamino)benzenecarboximidamide Thiazolyl blue formazan" [P]. US Patent, US 11454591 B2, 2019-05-16.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of MTT 甲臜 in Pharmaceutical Formulations". Food Chem., 2021, 1493, 2541-2556.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of MTT 甲臜 as an Impurity". Anal. Methods, 2016, 431, (12), 6344-6357.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of (NE,E)-N-[(dimethyl-1,3-thiazol-2-yl)imino]-N'-(phenylamino)benzene-1-carboximidamide 1-(4,5-Dimethylthiazol-2-yl)-3,5-diphenylformazan 57360-69-7 N-[(dimethyl-1,3-thiazol-2-yl)imino]-N'-(phenylamino)benzenecarboximidamide Thiazolyl blue formazan Using HRMS and NMR". Molecules, 2010, 212, (4), 9540-9567.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate MTT 甲臜 Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2022, 1351, (2), 3369-3388.

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