CAS 574-95-8

574-95-8 aureothricin N-(4-methyl-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)propanamide N-{4-methyl-5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6- yl}propanamide N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propionamide 4-methyl-6-propionamido-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one propanoyl-pyrrothine propionopyrrothine CHEBI:156452

纯度 97%+现货药物标准品
CAS 号574-95-8
分子式C9H10N2O2S2
分子量242.32 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

574-95-8 aureothricin N-(4-methyl-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)propanamide N-{4-methyl-5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6- yl}propanamide N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propionamide 4-methyl-6-propionamido-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one propanoyl-pyrrothine propionopyrrothine CHEBI:156452 CAS 574-95-8 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品（574-95-8 aureothricin N-(4-methyl-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)propanamide N-{4-methyl-5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6- yl}propanamide N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propionamide 4-methyl-6-propionamido-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one propanoyl-pyrrothine propionopyrrothine CHEBI:156452，CAS 574-95-8），分子式 C9H10N2O2S2，分子量 242.32。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

受分子结构中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键的影响，表现为类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味）。其固体形态的物理化学属性——包括242.32 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 （574-95-8 aureothricin N-(4-methyl-5-oxo-4,5-dihydro1,2dithiolo4,3-bpyrrol-6-yl)propanamide N-{4-methyl-5-oxo-4H,5H-1,2dithiolo4,3-bpyrrol-6- yl}propanamide N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo4,3-bpyrrol-6-yl)propionamide 4-methyl-6-propionamido-1,2-dithiolo4,3-bpyrrol-5(4H)-one propanoyl-pyrrothine

应用场景：（574-95-8 aureothricin N-(4-methyl-5-oxo-4,5-dihydro 1,2 dithiolo 4,3-b pyrrol-6-yl)propanamide N-{4-methyl-5-oxo-4H,5H- 1,2 dithiolo 4,3-b pyrrol-6- yl}propanamide N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo 4,3-b pyrrol-6-yl)propionamide 4-methyl-6-propionamido-1,2-dithiolo 4,3-b pyrrol-5(4H)-one p

理化性质 Physical & Chemical Properties

中文名称
分子式C9H10N2O2S2
分子量242.32 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年
含氮原子数2
含硫原子数2

相关专利 Related Patents

  1. 发明人高志强，郑宇鹏，何建平. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 108060539 A, 授权公告日 2021-05-01.
  2. 发明人林芳，孙丽萍，郑宇鹏. "Method for the Synthesis of 574-95-8 aureothricin N-(4-methyl-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)propanamide N-{4-methyl-5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6- yl}propanamide N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propionamide 4-methyl-6-propionamido-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one propanoyl-pyrrothine propionopyrrothine CHEBI:156452" [P]. 中国发明专利, 专利号 CN 113333652 B, 授权公告日 2015-04-15.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Agric. Food Chem., 2024, 527, 4478-4493.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Environ. Sci. Technol., 2019, 2306, (7), 888-911.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of 574-95-8 aureothricin N-(4-methyl-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)propanamide N-{4-methyl-5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6- yl}propanamide N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propionamide 4-methyl-6-propionamido-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one propanoyl-pyrrothine propionopyrrothine CHEBI:156452 Using HRMS and NMR". Biomed. Chromatogr., 2010, 435, (1), 2911-2939.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2010, 1538, (9), 9513-9520.

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