4-Isothiocyanatobenzoyl-<SC>DL</SC>-homoserine lactone CAS 58394-58-4

58394-58-4 4-Isothiocyanatobenzoyl-DL-homoserine lactone Benzamide, 4-isothiocyanato-N-(tetrahydro-2-oxo-3-furanyl)-, (+-)- p-Isothiocyanatobenzoyl-DL-homoserine lactone para-Isothiocyanatobenzoyl-DL-homoserine lactone

纯度 97%+现货药物标准品
CAS 号58394-58-4
分子式C12H16N2O3S
分子量268.33 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-Isothiocyanatobenzoyl-<SC>DL</SC>-homoserine lactone 58394-58-4 4-Isothiocyanatobenzoyl-DL-homoserine lactone Benzamide, 4-isothiocyanato-N-(tetrahydro-2-oxo-3-furanyl)-, (+-)- p-Isothiocyanatobenzoyl-DL-homoserine lactone para-Isothiocyanatobenzoyl-DL-homoserine lactone CAS 58394-58-4 结构式 Chemical Structure

产品介绍 Description

CAS 58394-58-4 对应的4-Isothiocyanatobenzoyl-<SC>DL</SC>-homoserine lactone（58394-58-4 4-Isothiocyanatobenzoyl-DL-homoserine lactone Benzamide, 4-isothiocyanato-N-(tetrahydro-2-oxo-3-furanyl)-, (+-)- p-Isothiocyanatobenzoyl-DL-homoserine lactone para-Isothiocyanatobenzoyl-DL-homoserine lactone）为 CATO 佳途药物标准品产品线成员。分子式 C12H16N2O3S，分子量 268.33。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 4-Isothiocyanatobenzoyl-<SC>DL</SC>-homoserine lactone（58394-58-4 4-Isothiocyanatobenzoyl-DL-homoserine lactone Benzamide, 4-isothiocyanato-N-(tetrahydro-2-oxo-3-furanyl)-, (+-)- p-Isothiocyanatobenzoyl-DL-homoserine lactone para-Isothiocyanatobenzoyl-DL-homoserine lactone），CAS注册编号 58394-58-4，化学分子式为 C12H16N2O3S，分子量 268.33 g/mol。 受分子结构中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键的影响，4-Isothiocyanatobenzoyl-<SC>DL</SC>-homoserine lactone表现为类白色至淡黄色

应用场景：从实际应用出发，4-Isothiocyanatobenzoyl-<SC>DL</SC>-homoserine lactone（CAS 58394-58-4）在化学分析中作为关键的基准对照物质。 推荐以4-Isothiocyanatobenzoyl-<SC>DL</SC>-homoserine lactone配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密封防潮

理化性质 Physical & Chemical Properties

中文名称4-Isothiocyanatobenzoyl-<SC>DL</SC>-homoserine lactone
分子式C12H16N2O3S
分子量268.33 g/mol
外观形态类白色至淡黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1973年
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. 发明人朱建伟，王建平，陈志强. "一种4-Isothiocyanatobenzoyl-<SC>DL</SC>-homoserine lactone的合成方法" [P]. 中国发明专利, 专利号 CN 112452223 A, 授权公告日 2020-02-22.
  2. 发明人杨光，马晓峰，李文辉. "Method for the Synthesis of 58394-58-4 4-Isothiocyanatobenzoyl-DL-homoserine lactone Benzamide, 4-isothiocyanato-N-(tetrahydro-2-oxo-3-furanyl)-, (+-)- p-Isothiocyanatobenzoyl-DL-homoserine lactone para-Isothiocyanatobenzoyl-DL-homoserine lactone" [P]. 中国发明专利, 专利号 CN 108160260 B, 授权公告日 2016-03-18.
  3. 发明人朱建伟，罗永刚，杨光. "A Process for Preparing High-Purity 58394-58-4 4-Isothiocyanatobenzoyl-DL-homoserine lactone Benzamide, 4-isothiocyanato-N-(tetrahydro-2-oxo-3-furanyl)-, (+-)- p-Isothiocyanatobenzoyl-DL-homoserine lactone para-Isothiocyanatobenzoyl-DL-homoserine lactone" [P]. 中国发明专利, 专利号 CN 116327129 B, 授权公告日 2018-08-07.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of 4-Isothiocyanatobenzoyl-<SC>DL</SC>-homoserine lactone in Pharmaceutical Formulations". Molecules, 2024, 775, (11), 4411-4439.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-Isothiocyanatobenzoyl-<SC>DL</SC>-homoserine lactone as an Impurity". Environ. Sci. Technol., 2019, 539, 2808-2818.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 58394-58-4 4-Isothiocyanatobenzoyl-DL-homoserine lactone Benzamide, 4-isothiocyanato-N-(tetrahydro-2-oxo-3-furanyl)-, (+-)- p-Isothiocyanatobenzoyl-DL-homoserine lactone para-Isothiocyanatobenzoyl-DL-homoserine lactone Using HRMS and NMR". Talanta, 2012, 1062, 1973-1978.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate 4-Isothiocyanatobenzoyl-<SC>DL</SC>-homoserine lactone Profile in Drug Substances According to ICH Guidelines". Food Chem., 2014, 1675, (12), 6228-6252.

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