18:0 SM (d18:1/18:0) CAS 58909-84-5

(2S,3R,4E)-3-hydroxy-2-(octadecanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate (2S,3R,4E)-3-hydroxy-2-(stearoylamino)octadec-4-en-1-yl 2-(trimethylammonio)ethyl phosphate 2,3-(N-Steroylsphingosyl)-1-phosphocholine 2,3-Sppc 58909-84-5 C18 Sphingomyelin CHEBI:83358 N-(octadecanoyl)-sphing-4-enine-1-phosphocholine N-octadecanoylsphing-4-enine-1-phosphocholine N-octadecanoylsphingosine-1-phosphocholine N-stearoylsphing-4-enine-1-phosphocholine N-stearoylsphingosine-1-phosphocholine SM(d18:1/18:0) sphingomyelin (d18:1/18:0) stearoyl sphingomyelin

纯度 97%+现货药物标准品
CAS 号58909-84-5
分子式C41H83N2O6P
分子量731.08 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

18:0 SM (d18:1/18:0) (2S,3R,4E)-3-hydroxy-2-(octadecanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate (2S,3R,4E)-3-hydroxy-2-(stearoylamino)octadec-4-en-1-yl 2-(trimethylammonio)ethyl phosphate 2,3-(N-Steroylsphingosyl)-1-phosphocholine 2,3-Sppc 58909-84-5 C18 Sphingomyelin CHEBI:83358 N-(octadecanoyl)-sphing-4-enine-1-phosphocholine N-octadecanoylsphing-4-enine-1-phosphocholine N-octadecanoylsphingosine-1-phosphocholine N-stearoylsphing-4-enine-1-phosphocholine N-stearoylsphingosine-1-phosphocholine SM(d18:1/18:0) sphingomyelin (d18:1/18:0) stearoyl sphingomyelin CAS 58909-84-5 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品18:0 SM (d18:1/18:0)（(2S,3R,4E)-3-hydroxy-2-(octadecanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate (2S,3R,4E)-3-hydroxy-2-(stearoylamino)octadec-4-en-1-yl 2-(trimethylammonio)ethyl phosphate 2,3-(N-Steroylsphingosyl)-1-phosphocholine 2,3-Sppc 58909-84-5 C18 Sphingomyelin CHEBI:83358 N-(octadecanoyl)-sphing-4-enine-1-phosphocholine N-octadecanoylsphing-4-enine-1-phosphocholine N-octadecanoylsphingosine-1-phosphocholine N-stearoylsphing-4-enine-1-phosphocholine N-stearoylsphingosine-1-phosphocholine SM(d18:1/18:0) sphingomyelin (d18:1/18:0) stearoyl sphingomyelin，CAS 58909-84-5），分子式 C41H83N2O6P，分子量 731.08。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

依据分子式为 C41H83N2O6P 的18:0 SM (d18:1/18:0)结构特征，其分子内含酰胺类，含磷酸酯基，羧酸类，含羟基，含醚键，这意味着该化合物在红外光谱中会呈现特征性的官能团伸缩振动信号。分子量 731.08 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 化学式为 C41H83N2O6P 的18:0 SM (d18:1/18:0)（(2S,3R,4E)-3-hydroxy-2-(octadecanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate (2S,3R,4E)-3-hydroxy-2-(stearoylamino)octadec-4-en-1-yl 2-(trimethylammonio)ethyl phosphate 2,3-(N-Steroylsphingosyl)-1-phosphocholine 2,3-Sppc 58909-84-5 C18 Sphingomyelin CHE

应用场景：从实际应用出发，18:0 SM (d18:1/18:0)（CAS 58909-84-5）在化学分析中作为关键的基准对照物质。 推荐以18:0 SM (d18:1/18:0)配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于阴凉处（≤25°C）保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使

理化性质 Physical & Chemical Properties

中文名称18:0 SM (d18:1/18:0)
分子式C41H83N2O6P
分子量731.08 g/mol
外观形态白色至类白色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.5
CAS登记年份（估）1973年
含氮原子数2

相关专利 Related Patents

  1. 发明人李文辉，赵玉洁，黄志刚. "一种18:0 SM (d18:1/18:0)的合成方法" [P]. 中国发明专利, 专利号 CN 113740830 A, 授权公告日 2021-07-04.
  2. 发明人沈红梅，王建平，陈志强. "Method for the Synthesis of (2S,3R,4E)-3-hydroxy-2-(octadecanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate (2S,3R,4E)-3-hydroxy-2-(stearoylamino)octadec-4-en-1-yl 2-(trimethylammonio)ethyl phosphate 2,3-(N-Steroylsphingosyl)-1-phosphocholine 2,3-Sppc 58909-84-5 C18 Sphingomyelin CHEBI:83358 N-(octadecanoyl)-sphing-4-enine-1-phosphocholine N-octadecanoylsphing-4-enine-1-phosphocholine N-octadecanoylsphingosine-1-phosphocholine N-stearoylsphing-4-enine-1-phosphocholine N-stearoylsphingosine-1-phosphocholine SM(d18:1/18:0) sphingomyelin (d18:1/18:0) stearoyl sphingomyelin" [P]. 中国发明专利, 专利号 CN 115393304 B, 授权公告日 2018-12-25.
  3. 发明人王建平，胡光，徐明华. "A Process for Preparing High-Purity (2S,3R,4E)-3-hydroxy-2-(octadecanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate (2S,3R,4E)-3-hydroxy-2-(stearoylamino)octadec-4-en-1-yl 2-(trimethylammonio)ethyl phosphate 2,3-(N-Steroylsphingosyl)-1-phosphocholine 2,3-Sppc 58909-84-5 C18 Sphingomyelin CHEBI:83358 N-(octadecanoyl)-sphing-4-enine-1-phosphocholine N-octadecanoylsphing-4-enine-1-phosphocholine N-octadecanoylsphingosine-1-phosphocholine N-stearoylsphing-4-enine-1-phosphocholine N-stearoylsphingosine-1-phosphocholine SM(d18:1/18:0) sphingomyelin (d18:1/18:0) stearoyl sphingomyelin" [P]. 中国发明专利, 专利号 CN 115805276 A, 授权公告日 2023-12-17.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 18:0 SM (d18:1/18:0) in Pharmaceutical Formulations". J. Chromatogr. A, 2015, 1230, (3), 155-163.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 18:0 SM (d18:1/18:0) as an Impurity". J. Pharm. Biomed. Anal., 2025, 2257, (4), 6841-6866.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of (2S,3R,4E)-3-hydroxy-2-(octadecanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate (2S,3R,4E)-3-hydroxy-2-(stearoylamino)octadec-4-en-1-yl 2-(trimethylammonio)ethyl phosphate 2,3-(N-Steroylsphingosyl)-1-phosphocholine 2,3-Sppc 58909-84-5 C18 Sphingomyelin CHEBI:83358 N-(octadecanoyl)-sphing-4-enine-1-phosphocholine N-octadecanoylsphing-4-enine-1-phosphocholine N-octadecanoylsphingosine-1-phosphocholine N-stearoylsphing-4-enine-1-phosphocholine N-stearoylsphingosine-1-phosphocholine SM(d18:1/18:0) sphingomyelin (d18:1/18:0) stearoyl sphingomyelin Using HRMS and NMR". Sci. Total Environ., 2021, 983, (3), 3319-3323.

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