罗汉松酸 CAS 5947-49-9

5947-49-9 7K80G5Z96Y Podocarpic acid (1S,4AS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S-(1alpha,4aalpha,10abeta))- (9CI) Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (VAN) (8CI) EINECS 227-706-3 NSC 231784 UNII-7K80G5Z96Y

纯度 97%+现货药物标准品
CAS 号5947-49-9
分子式C17H28O3
分子量280.40 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

罗汉松酸 5947-49-9 7K80G5Z96Y Podocarpic acid (1S,4AS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S-(1alpha,4aalpha,10abeta))- (9CI) Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (VAN) (8CI) EINECS 227-706-3 NSC 231784 UNII-7K80G5Z96Y CAS 5947-49-9 结构式 Chemical Structure

产品介绍 Description

罗汉松酸（英文名 5947-49-9 7K80G5Z96Y Podocarpic acid (1S,4AS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S-(1alpha,4aalpha,10abeta))- (9CI) Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (VAN) (8CI) EINECS 227-706-3 NSC 231784 UNII-7K80G5Z96Y，CAS 5947-49-9）属于药物标准品。分子式 C17H28O3，分子量 280.40。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

罗汉松酸的产生途径与其化学式中甾体骨架，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 5947-49-9 对应的化合物罗汉松酸（英文标识 5947-49-9 7K80G5Z96Y Podocarpic acid (1S,4AS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S-(1alpha,4aalpha,10abeta))- (9CI) Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (VAN) (8CI) EINECS 227-706-3 NSC 231784 UNII-7K80G5Z96Y），化学式 C17H28O3，相对分子质量 280.40。 罗汉松酸（分子式 C

应用场景：从实际应用出发，罗汉松酸（CAS 5947-49-9）在化学分析中作为关键的基准对照物质。 推荐以罗汉松酸配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于室温保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称罗汉松酸
分子式C17H28O3
分子量280.40 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1958年

相关专利 Related Patents

  1. Nowak P, Martínez F, Johansson L. "一种罗汉松酸的合成方法" [P]. European Patent, EP 3134913 A1, 2019-04-28.
  2. Nielsen H, Lefèvre J P, Mueller T C. "Method for the Synthesis of 5947-49-9 7K80G5Z96Y Podocarpic acid (1S,4AS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S-(1alpha,4aalpha,10abeta))- (9CI) Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (VAN) (8CI) EINECS 227-706-3 NSC 231784 UNII-7K80G5Z96Y" [P]. European Patent, EP 3938890 A1, 2020-08-21.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 罗汉松酸 in Pharmaceutical Formulations". Talanta, 2021, 995, (9), 5544-5555.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 罗汉松酸 as an Impurity". J. Agric. Food Chem., 2017, 145, 8628-8649.
  3. Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of 5947-49-9 7K80G5Z96Y Podocarpic acid (1S,4AS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S-(1alpha,4aalpha,10abeta))- (9CI) Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (VAN) (8CI) EINECS 227-706-3 NSC 231784 UNII-7K80G5Z96Y Using HRMS and NMR". Biomed. Chromatogr., 2023, 147, (10), 3322-3351.

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