分支酸 来源于<I>产气肠杆菌</I> CAS 617-12-9

(-)-Chorismic acid (3R-trans)-3-(1-Carboxyvinyloxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyethenyl)oxy]-4-hydroxy-, (3R,4R)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyethenyl)oxy]-4-hydroxy-, (3R-trans)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyvinyl)oxy]-4-hydroxy-, (3R-trans)- 617-12-9 Chorismic acid chorismate

纯度 97%+现货药物标准品
CAS 号617-12-9
分子式C10H10O6
分子量226.18 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

分支酸 来源于<I>产气肠杆菌</I> (-)-Chorismic acid (3R-trans)-3-(1-Carboxyvinyloxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyethenyl)oxy]-4-hydroxy-, (3R,4R)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyethenyl)oxy]-4-hydroxy-, (3R-trans)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyvinyl)oxy]-4-hydroxy-, (3R-trans)- 617-12-9 Chorismic acid chorismate CAS 617-12-9 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品分支酸 来源于<I>产气肠杆菌</I>（(-)-Chorismic acid (3R-trans)-3-(1-Carboxyvinyloxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyethenyl)oxy]-4-hydroxy-, (3R,4R)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyethenyl)oxy]-4-hydroxy-, (3R-trans)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyvinyl)oxy]-4-hydroxy-, (3R-trans)- 617-12-9 Chorismic acid chorismate，CAS 617-12-9），分子式 C10H10O6，分子量 226.18。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

作为认证标准物质（CRM），分支酸 来源于<I>产气肠杆菌</I>满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 分支酸 来源于<I>产气肠杆菌</I>（(-)-Chorismic acid (3R-trans)-3-(1-Carboxyvinyloxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid 1,5-Cyclohexadiene-1-carboxylic acid, 3-(1-carboxyethenyl)oxy-4-hydroxy-, (3R,4R)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-(1-carboxyethenyl)oxy-4-hydroxy-, (3R-trans)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-(1-carboxyvinyl)oxy-4-hydroxy-, (3R-t

应用场景：分支酸 来源于<I>产气肠杆菌</I>（(-)-Chorismic acid (3R-trans)-3-(1-Carboxyvinyloxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid 1,5-Cyclohexadiene-1-carboxylic acid, 3- (1-carboxyethenyl)oxy -4-hydroxy-, (3R,4R)- 1,5-Cyclohexadiene-1-carboxylic acid, 3- (1-carboxyethenyl)oxy -4-hydroxy-, (3R-trans)- 1,5-Cycl

理化性质 Physical & Chemical Properties

中文名称分支酸 来源于<I>产气肠杆菌</I>
分子式C10H10O6
分子量226.18 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年

相关专利 Related Patents

  1. 发明人钱学锋，郑宇鹏，马晓峰. "一种分支酸 来源于<I>产气肠杆菌</I>的合成方法" [P]. 中国发明专利, 专利号 CN 111354268 A, 授权公告日 2020-01-05.
  2. Patel M V, Fischer A B, Kumar R. "Method for the Synthesis of (-)-Chorismic acid (3R-trans)-3-(1-Carboxyvinyloxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyethenyl)oxy]-4-hydroxy-, (3R,4R)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyethenyl)oxy]-4-hydroxy-, (3R-trans)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyvinyl)oxy]-4-hydroxy-, (3R-trans)- 617-12-9 Chorismic acid chorismate" [P]. US Patent, US 9550760 B2, 2025-08-17.
  3. Sørensen M, Lefèvre J P, Nowak P. "A Process for Preparing High-Purity (-)-Chorismic acid (3R-trans)-3-(1-Carboxyvinyloxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyethenyl)oxy]-4-hydroxy-, (3R,4R)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyethenyl)oxy]-4-hydroxy-, (3R-trans)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyvinyl)oxy]-4-hydroxy-, (3R-trans)- 617-12-9 Chorismic acid chorismate" [P]. European Patent, EP 3257903 A1, 2021-11-13.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 分支酸 来源于<I>产气肠杆菌</I> in Pharmaceutical Formulations". Anal. Chem., 2023, 1280, (1), 8067-8075.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 分支酸 来源于<I>产气肠杆菌</I> as an Impurity". Sci. Total Environ., 2013, 1493, (3), 4153-4157.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of (-)-Chorismic acid (3R-trans)-3-(1-Carboxyvinyloxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyethenyl)oxy]-4-hydroxy-, (3R,4R)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyethenyl)oxy]-4-hydroxy-, (3R-trans)- 1,5-Cyclohexadiene-1-carboxylic acid, 3-[(1-carboxyvinyl)oxy]-4-hydroxy-, (3R-trans)- 617-12-9 Chorismic acid chorismate Using HRMS and NMR". J. Chromatogr. A, 2010, 893, (3), 1116-1137.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate 分支酸 来源于<I>产气肠杆菌</I> Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2023, 2360, (12), 6356-6372.

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