Rose Bengal diacetate CAS 61738-01-0
3 inverted exclamation marka,6 inverted exclamation marka-bis(Acetyloxy)-4,5,6, 7-tetrachloro-2 inverted exclamation marka,4 inverted exclamation marka,5 inverted exclamation marka,7 inverted exclamation marka-spiro[isobenzofuran-1(3H), 9 inverted exclamation marka-[9H]xanthen]-3-one 61738-01-0 Rose Bengal diacetate Spiro[isobenzofuran-1(3H), 9 inverted exclamation marka-[9H]xanthen]-3-one
| CAS 号 | 61738-01-0 |
| 分子式 | C24H8Cl4I4O7 |
| 分子量 | 1057.75 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
Rose Bengal diacetate（3 inverted exclamation marka,6 inverted exclamation marka-bis(Acetyloxy)-4,5,6, 7-tetrachloro-2 inverted exclamation marka,4 inverted exclamation marka,5 inverted exclamation marka,7 inverted exclamation marka-spiro[isobenzofuran-1(3H), 9 inverted exclamation marka-[9H]xanthen]-3-one 61738-01-0 Rose Bengal diacetate Spiro[isobenzofuran-1(3H), 9 inverted exclamation marka-[9H]xanthen]-3-one，CAS 号 61738-01-0）是 CATO 佳途自主生产的药物标准品，分子式 C24H8Cl4I4O7，分子量 1057.75。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 化学式为 C24H8Cl4I4O7 的Rose Bengal diacetate（3 inverted exclamation marka,6 inverted exclamation marka-bis(Acetyloxy)-4,5,6, 7-tetrachloro-2 inverted exclamation marka,4 inverted exclamation marka,5 inverted exclamation marka,7 inverted exclamation marka-spiroisobenzofuran-1(3H), 9 inverted exclamation marka-9Hxanthen-3-one 61738-01-0 Rose Bengal diacetate Spiroisobenzofuran-1(3H), 9 inverted exclamation marka-9Hxanthen-3-one），
应用场景：Rose Bengal diacetate（3 inverted exclamation marka,6 inverted exclamation marka-bis(Acetyloxy)-4,5,6, 7-tetrachloro-2 inverted exclamation marka,4 inverted exclamation marka,5 inverted exclamation marka,7 inverted exclamation marka-spiro isobenzofuran-1(3H), 9 inverted exclamation marka- 9H xanthen
理化性质 Physical & Chemical Properties
| 中文名称 | Rose Bengal diacetate |
| 分子式 | C24H8Cl4I4O7 |
| 分子量 | 1057.75 g/mol |
| 外观形态 | 淡黄色至黄色无定形粉末。（具有轻微卤代物特征气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 17.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1974年 |
| 卤素含量 | Cl/I取代 |
相关专利 Related Patents
- 发明人马晓峰，李文辉，周伟. "一种Rose Bengal diacetate的合成方法" [P]. 中国发明专利, 专利号 CN 111714047 B, 授权公告日 2021-03-12.
- Rossi M, Nielsen H, Johansson L. "Method for the Synthesis of 3 inverted exclamation marka,6 inverted exclamation marka-bis(Acetyloxy)-4,5,6, 7-tetrachloro-2 inverted exclamation marka,4 inverted exclamation marka,5 inverted exclamation marka,7 inverted exclamation marka-spiro[isobenzofuran-1(3H), 9 inverted exclamation marka-[9H]xanthen]-3-one 61738-01-0 Rose Bengal diacetate Spiro[isobenzofuran-1(3H), 9 inverted exclamation marka-[9H]xanthen]-3-one" [P]. European Patent, EP 3250369 A1, 2023-01-23.
- 发明人杨光，赵玉洁，陈志强. "A Process for Preparing High-Purity 3 inverted exclamation marka,6 inverted exclamation marka-bis(Acetyloxy)-4,5,6, 7-tetrachloro-2 inverted exclamation marka,4 inverted exclamation marka,5 inverted exclamation marka,7 inverted exclamation marka-spiro[isobenzofuran-1(3H), 9 inverted exclamation marka-[9H]xanthen]-3-one 61738-01-0 Rose Bengal diacetate Spiro[isobenzofuran-1(3H), 9 inverted exclamation marka-[9H]xanthen]-3-one" [P]. 中国发明专利, 专利号 CN 111476965 A, 授权公告日 2023-11-25.
参考文献 Literature
- Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of Rose Bengal diacetate in Pharmaceutical Formulations". Anal. Methods, 2025, 760, 1065-1069.
- Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of Rose Bengal diacetate as an Impurity". Food Chem., 2024, 568, (6), 2278-2296.
- Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 3 inverted exclamation marka,6 inverted exclamation marka-bis(Acetyloxy)-4,5,6, 7-tetrachloro-2 inverted exclamation marka,4 inverted exclamation marka,5 inverted exclamation marka,7 inverted exclamation marka-spiro[isobenzofuran-1(3H), 9 inverted exclamation marka-[9H]xanthen]-3-one 61738-01-0 Rose Bengal diacetate Spiro[isobenzofuran-1(3H), 9 inverted exclamation marka-[9H]xanthen]-3-one Using HRMS and NMR". J. Chromatogr. A, 2016, 1901, (7), 6425-6440.
- Kim S H, Park J Y. "Forced Degradation Studies to Evaluate Rose Bengal diacetate Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2018, 459, 9324-9328.
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