N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide CAS 618107-92-9

618107-92-9 A833431 tert-butyl-[2-[2-(2,2-dimethylpropanoylamino)pyridin-4-yl]propan-2-yloxy]silicon tert-butyl-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4-pyridinyl]propan-2-yloxy]silicon

纯度 97%+现货药物标准品
CAS 号618107-92-9
分子式C17H36N2O2Si
分子量328.57 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide 618107-92-9 A833431 tert-butyl-[2-[2-(2,2-dimethylpropanoylamino)pyridin-4-yl]propan-2-yloxy]silicon tert-butyl-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4-pyridinyl]propan-2-yloxy]silicon CAS 618107-92-9 结构式 Chemical Structure

产品介绍 Description

N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide（618107-92-9 A833431 tert-butyl-[2-[2-(2,2-dimethylpropanoylamino)pyridin-4-yl]propan-2-yloxy]silicon tert-butyl-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4-pyridinyl]propan-2-yloxy]silicon）是药物分析与质量控制领域常用的药物标准品，CAS 号 618107-92-9。分子式 C17H36N2O2Si，分子量 328.57。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

N-4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl-2,2-dimethyl-propionamide的产生途径与其化学式中酰胺类，羧酸类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 N-4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl-2,2-dimethyl-propionamide（618107-92-9 A833431 tert-butyl-2-2-(2,2-dimethylpropanoylamino)pyridin-4-ylpropan-2-yloxysilicon tert-butyl-2-2-(2,2-dimethyl-1-oxopropyl)amino-4-pyridinylpropan-2-yloxysilicon），CAS注册编号 618107-92-9，化学分子式为 C17H36N2O2Si，分子量 328.57 g/mol。 N-4-(tert-Butyl-dimeth

应用场景：从实际应用出发，N- 4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl -2,2-dimethyl-propionamide（CAS 618107-92-9）在化学分析中作为关键的基准对照物质。 推荐以N- 4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl -2,2-dimethyl-propionamide配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品

理化性质 Physical & Chemical Properties

中文名称N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide
分子式C17H36N2O2Si
分子量328.57 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1985年
含氮原子数2

相关专利 Related Patents

  1. 发明人张德明，冯建国，黄志刚. "一种N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide的合成方法" [P]. 中国发明专利, 专利号 CN 113185131 B, 授权公告日 2022-01-07.
  2. Schröder R, Hughes D C, Yamamoto T. "Method for the Synthesis of 618107-92-9 A833431 tert-butyl-[2-[2-(2,2-dimethylpropanoylamino)pyridin-4-yl]propan-2-yloxy]silicon tert-butyl-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4-pyridinyl]propan-2-yloxy]silicon" [P]. US Patent, US 10710839 B2, 2018-05-21.
  3. Johnson M A, Fischer A B, Brown S R. "A Process for Preparing High-Purity 618107-92-9 A833431 tert-butyl-[2-[2-(2,2-dimethylpropanoylamino)pyridin-4-yl]propan-2-yloxy]silicon tert-butyl-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4-pyridinyl]propan-2-yloxy]silicon" [P]. US Patent, US 10883800 B2, 2020-05-14.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide in Pharmaceutical Formulations". Sci. Total Environ., 2023, 2011, (9), 8492-8522.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of N-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide as an Impurity". Rapid Commun. Mass Spectrom., 2017, 2103, (2), 8202-8224.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 618107-92-9 A833431 tert-butyl-[2-[2-(2,2-dimethylpropanoylamino)pyridin-4-yl]propan-2-yloxy]silicon tert-butyl-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4-pyridinyl]propan-2-yloxy]silicon Using HRMS and NMR". Chromatographia, 2024, 1005, (4), 9572-9591.

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