1-(三甲基硅基)丙炔 CAS 6224-91-5

1-(Trimethylsilyl)-1-propyne 1-(Trimethylsilyl)propyne 1-Methyl-2-trimethylsilylacetylene 1-Propynyltrimethylsilane 6224-91-5 Methyl(trimethylsilyl)acetylene Methyl(trimethylsilyl)ethyne T 3728 Trimethyl(1-propyn-1-yl)silane Trimethyl-1-propyn-1-ylsilane Trimethyl-1-propynylsilane trimethyl(prop-1-yn-1-yl)silane

纯度 97%+现货药物标准品
CAS 号6224-91-5
分子式C6H12Si
分子量112.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-(三甲基硅基)丙炔 1-(Trimethylsilyl)-1-propyne 1-(Trimethylsilyl)propyne 1-Methyl-2-trimethylsilylacetylene 1-Propynyltrimethylsilane 6224-91-5 Methyl(trimethylsilyl)acetylene Methyl(trimethylsilyl)ethyne T 3728 Trimethyl(1-propyn-1-yl)silane Trimethyl-1-propyn-1-ylsilane Trimethyl-1-propynylsilane trimethyl(prop-1-yn-1-yl)silane CAS 6224-91-5 结构式 Chemical Structure

产品介绍 Description

1-(三甲基硅基)丙炔（1-(Trimethylsilyl)-1-propyne 1-(Trimethylsilyl)propyne 1-Methyl-2-trimethylsilylacetylene 1-Propynyltrimethylsilane 6224-91-5 Methyl(trimethylsilyl)acetylene Methyl(trimethylsilyl)ethyne T 3728 Trimethyl(1-propyn-1-yl)silane Trimethyl-1-propyn-1-ylsilane Trimethyl-1-propynylsilane trimethyl(prop-1-yn-1-yl)silane，CAS 号 6224-91-5）是 CATO 佳途自主生产的药物标准品，分子式 C6H12Si，分子量 112.24。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

1-(三甲基硅基)丙炔（C6H12Si）含有有机化合物。其物理化学性质在同类化合物中具有代表性，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。 1-(三甲基硅基)丙炔（1-(Trimethylsilyl)-1-propyne 1-(Trimethylsilyl)propyne 1-Methyl-2-trimethylsilylacetylene 1-Propynyltrimethylsilane 6224-91-5 Methyl(trimethylsilyl)acetylene Methyl(trimethylsilyl)ethyne T 3728 Trimethyl(1-propyn-1-yl)silane Trimethyl-1-propyn-1-ylsilane Trimethyl-1-propynylsilane trimethyl(prop-1-yn-1-yl)silane），CAS注册编号 6224-91-5，化学分子式为 C6H12Si，分子量 112.24 g/mol。 本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定

应用场景：1-(三甲基硅基)丙炔（1-(Trimethylsilyl)-1-propyne 1-(Trimethylsilyl)propyne 1-Methyl-2-trimethylsilylacetylene 1-Propynyltrimethylsilane 6224-91-5 Methyl(trimethylsilyl)acetylene Methyl(trimethylsilyl)ethyne T 3728 Trimethyl(1-propyn-1-yl)silane Trimethyl-1-propyn-1-ylsilane Trimethyl-1-propynylsilane trimet

理化性质 Physical & Chemical Properties

中文名称1-(三甲基硅基)丙炔
分子式C6H12Si
分子量112.24 g/mol
外观形态白色至类白色液体
纯度97%+
储存条件2-8°C冷藏保存
溶解性参考可溶于甲醇、乙腈、DMSO
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1958年

相关专利 Related Patents

  1. Rossi M, Schröder R, Sørensen M. "一种1-(三甲基硅基)丙炔的合成方法" [P]. European Patent, EP 3946226 A1, 2023-04-19.
  2. 发明人王建平，唐晓军，钱学锋. "Method for the Synthesis of 1-(Trimethylsilyl)-1-propyne 1-(Trimethylsilyl)propyne 1-Methyl-2-trimethylsilylacetylene 1-Propynyltrimethylsilane 6224-91-5 Methyl(trimethylsilyl)acetylene Methyl(trimethylsilyl)ethyne T 3728 Trimethyl(1-propyn-1-yl)silane Trimethyl-1-propyn-1-ylsilane Trimethyl-1-propynylsilane trimethyl(prop-1-yn-1-yl)silane" [P]. 中国发明专利, 专利号 CN 112898097 A, 授权公告日 2025-10-12.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(三甲基硅基)丙炔 in Pharmaceutical Formulations". Phytochemistry, 2012, 1560, 5904-5919.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(三甲基硅基)丙炔 as an Impurity". J. Chromatogr. A, 2014, 1196, 685-695.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 1-(Trimethylsilyl)-1-propyne 1-(Trimethylsilyl)propyne 1-Methyl-2-trimethylsilylacetylene 1-Propynyltrimethylsilane 6224-91-5 Methyl(trimethylsilyl)acetylene Methyl(trimethylsilyl)ethyne T 3728 Trimethyl(1-propyn-1-yl)silane Trimethyl-1-propyn-1-ylsilane Trimethyl-1-propynylsilane trimethyl(prop-1-yn-1-yl)silane Using HRMS and NMR". Molecules, 2021, 2251, (7), 2294-2301.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 1-(三甲基硅基)丙炔 Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2010, 252, 4413-4437.

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