Ethyl 2-methyl-1,3-dioxolane-2-acetate CAS 6413-10-1
6413-10-1 G5EXI4NID0 Ethyl acetoacetate ethyleneglycol ketal 1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester Ethyl 2-methyl-1,3-dioxolane-2-acetate 5-19-07-00231 (Beilstein Handbook Reference) AI3-06368 BRN 0130164 EINECS 229-114-0 Ethyl acetoacetate 3-ethylene acetal Ethyl acetoacetate ethylene glycol ketal Ethyl acetoacetate ethylene ketal Ethyl 3-oxobutyrate ethylene ketal Ethylacetoacetate ethyleneglycol ketal Fructone 2-Methyl-1,3-dioxolane-2-acetic acid ethyl ester NSC 6537 UNII-G5EXI4NID0 EC 229-114-0
| CAS 号 | 6413-10-1 |
| 分子式 | C8H14O4 |
| 分子量 | 174.19 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
Ethyl 2-methyl-1,3-dioxolane-2-acetate（6413-10-1 G5EXI4NID0 Ethyl acetoacetate ethyleneglycol ketal 1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester Ethyl 2-methyl-1,3-dioxolane-2-acetate 5-19-07-00231 (Beilstein Handbook Reference) AI3-06368 BRN 0130164 EINECS 229-114-0 Ethyl acetoacetate 3-ethylene acetal Ethyl acetoacetate ethylene glycol ketal Ethyl acetoacetate ethylene ketal Ethyl 3-oxobutyrate ethylene ketal Ethylacetoacetate ethyleneglycol ketal Fructone 2-Methyl-1,3-dioxolane-2-acetic acid ethyl ester NSC 6537 UNII-G5EXI4NID0 EC 229-114-0，CAS 号 6413-10-1）是 CATO 佳途自主生产的药物标准品，分子式 C8H14O4，分子量 174.19。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括Ethyl 2-methyl-1,3-dioxolane-2-acetate在内的目标物的控制。 CAS编号 6413-10-1 对应的化合物Ethyl 2-methyl-1,3-dioxolane-2-acetate（英文标识 6413-10-1 G5EXI4NID0 Ethyl acetoacetate ethyleneglycol ketal 1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester Ethyl 2-methyl-1,3-dioxolane-2-acetate 5-19-07-00231 (Beilstein Handbook Reference) AI3-06368 BRN 0130164 EINECS 229-114-0 Ethyl acetoacetate 3-ethylene acetal Ethyl acetoacetate ethylene glycol ketal Ethyl acetoacetate ethylene ketal Ethyl
应用场景：从实际应用出发，Ethyl 2-methyl-1,3-dioxolane-2-acetate（CAS 6413-10-1）在化学分析中作为关键的基准对照物质。 推荐以Ethyl 2-methyl-1,3-dioxolane-2-acetate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西
理化性质 Physical & Chemical Properties
| 中文名称 | Ethyl 2-methyl-1,3-dioxolane-2-acetate |
| 分子式 | C8H14O4 |
| 分子量 | 174.19 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 2.0 |
| CAS登记年份（估） | 1958年 |
相关专利 Related Patents
- 发明人李文辉，朱建伟，孙丽萍. "一种Ethyl 2-methyl-1,3-dioxolane-2-acetate的合成方法" [P]. 中国发明专利, 专利号 CN 111141290 A, 授权公告日 2015-04-03.
- 发明人朱建伟，高志强，唐晓军. "Method for the Synthesis of 6413-10-1 G5EXI4NID0 Ethyl acetoacetate ethyleneglycol ketal 1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester Ethyl 2-methyl-1,3-dioxolane-2-acetate 5-19-07-00231 (Beilstein Handbook Reference) AI3-06368 BRN 0130164 EINECS 229-114-0 Ethyl acetoacetate 3-ethylene acetal Ethyl acetoacetate ethylene glycol ketal Ethyl acetoacetate ethylene ketal Ethyl 3-oxobutyrate ethylene ketal Ethylacetoacetate ethyleneglycol ketal Fructone 2-Methyl-1,3-dioxolane-2-acetic acid ethyl ester NSC 6537 UNII-G5EXI4NID0 EC 229-114-0" [P]. 中国发明专利, 专利号 CN 117400249 B, 授权公告日 2023-04-15.
- 发明人胡光，何建平，林芳. "A Process for Preparing High-Purity 6413-10-1 G5EXI4NID0 Ethyl acetoacetate ethyleneglycol ketal 1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester Ethyl 2-methyl-1,3-dioxolane-2-acetate 5-19-07-00231 (Beilstein Handbook Reference) AI3-06368 BRN 0130164 EINECS 229-114-0 Ethyl acetoacetate 3-ethylene acetal Ethyl acetoacetate ethylene glycol ketal Ethyl acetoacetate ethylene ketal Ethyl 3-oxobutyrate ethylene ketal Ethylacetoacetate ethyleneglycol ketal Fructone 2-Methyl-1,3-dioxolane-2-acetic acid ethyl ester NSC 6537 UNII-G5EXI4NID0 EC 229-114-0" [P]. 中国发明专利, 专利号 CN 113766600 A, 授权公告日 2015-02-28.
参考文献 Literature
- Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of Ethyl 2-methyl-1,3-dioxolane-2-acetate in Pharmaceutical Formulations". Biomed. Chromatogr., 2011, 1957, 5303-5332.
- Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of Ethyl 2-methyl-1,3-dioxolane-2-acetate as an Impurity". Talanta, 2019, 1551, (11), 6030-6036.
- Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 6413-10-1 G5EXI4NID0 Ethyl acetoacetate ethyleneglycol ketal 1,3-Dioxolane-2-acetic acid, 2-methyl-, ethyl ester Ethyl 2-methyl-1,3-dioxolane-2-acetate 5-19-07-00231 (Beilstein Handbook Reference) AI3-06368 BRN 0130164 EINECS 229-114-0 Ethyl acetoacetate 3-ethylene acetal Ethyl acetoacetate ethylene glycol ketal Ethyl acetoacetate ethylene ketal Ethyl 3-oxobutyrate ethylene ketal Ethylacetoacetate ethyleneglycol ketal Fructone 2-Methyl-1,3-dioxolane-2-acetic acid ethyl ester NSC 6537 UNII-G5EXI4NID0 EC 229-114-0 Using HRMS and NMR". Phytochemistry, 2024, 692, 9502-9520.
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