地索苯宁 CAS 65717-97-7

65717-97-7 4V891LH5NB Disofenin [USAN:INN:BAN] Disofenin Glycine, N-(2-((2,6-bis(1-methylethyl)phenyl)amino)-2-oxoethyl)-N-(carboxymethyl)- ((((2,6-Diisopropylphenyl)carbamoyl)methyl)imino)diacetic acid Disofenine [INN-French] Disofenino [INN-Spanish] Disofeninum [INN-Latin] Disofenine Disofenino Disofeninum UNII-4V891LH5NB DSIDA

纯度 97%+现货药物标准品
CAS 号65717-97-7
分子式C18H32N2O5
分子量356.46 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

地索苯宁 65717-97-7 4V891LH5NB Disofenin [USAN:INN:BAN] Disofenin Glycine, N-(2-((2,6-bis(1-methylethyl)phenyl)amino)-2-oxoethyl)-N-(carboxymethyl)- ((((2,6-Diisopropylphenyl)carbamoyl)methyl)imino)diacetic acid Disofenine [INN-French] Disofenino [INN-Spanish] Disofeninum [INN-Latin] Disofenine Disofenino Disofeninum UNII-4V891LH5NB DSIDA CAS 65717-97-7 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品地索苯宁（65717-97-7 4V891LH5NB Disofenin [USAN:INN:BAN] Disofenin Glycine, N-(2-((2,6-bis(1-methylethyl)phenyl)amino)-2-oxoethyl)-N-(carboxymethyl)- ((((2,6-Diisopropylphenyl)carbamoyl)methyl)imino)diacetic acid Disofenine [INN-French] Disofenino [INN-Spanish] Disofeninum [INN-Latin] Disofenine Disofenino Disofeninum UNII-4V891LH5NB DSIDA，CAS 65717-97-7），分子式 C18H32N2O5，分子量 356.46。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

化学式为 C18H32N2O5 的地索苯宁（65717-97-7 4V891LH5NB Disofenin USAN:INN:BAN Disofenin Glycine, N-(2-((2,6-bis(1-methylethyl)phenyl)amino)-2-oxoethyl)-N-(carboxymethyl)- ((((2,6-Diisopropylphenyl)carbamoyl)methyl)imino)diacetic acid Disofenine INN-French Disofenino INN-Spanish Disofeninum INN-Latin Disofenine Disofenino Disofeninum UNII-4V891LH5NB DSIDA），其CAS登记号是 65717-97-7，分子量为 356.46 g/mol。 地索苯宁（分子式 C18H32N2O5）的化学结构中包含甾体骨架，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要

应用场景：地索苯宁（65717-97-7 4V891LH5NB Disofenin USAN:INN:BAN Disofenin Glycine, N-(2-((2,6-bis(1-methylethyl)phenyl)amino)-2-oxoethyl)-N-(carboxymethyl)- ((((2,6-Diisopropylphenyl)carbamoyl)methyl)imino)diacetic acid Disofenine INN-French Disofenino INN-Spanish Disofeninum INN-Latin Disofenine Disofeni

理化性质 Physical & Chemical Properties

中文名称地索苯宁
分子式C18H32N2O5
分子量356.46 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1975年
含氮原子数2

相关专利 Related Patents

  1. 发明人徐明华，黄志刚，郑宇鹏. "一种地索苯宁的合成方法" [P]. 中国发明专利, 专利号 CN 113567215 B, 授权公告日 2015-03-16.
  2. Thompson G K, O'Brien P Q, Chen K W. "Method for the Synthesis of 65717-97-7 4V891LH5NB Disofenin [USAN:INN:BAN] Disofenin Glycine, N-(2-((2,6-bis(1-methylethyl)phenyl)amino)-2-oxoethyl)-N-(carboxymethyl)- ((((2,6-Diisopropylphenyl)carbamoyl)methyl)imino)diacetic acid Disofenine [INN-French] Disofenino [INN-Spanish] Disofeninum [INN-Latin] Disofenine Disofenino Disofeninum UNII-4V891LH5NB DSIDA" [P]. US Patent, US 11249199 B2, 2021-06-28.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 地索苯宁 in Pharmaceutical Formulations". Sci. Total Environ., 2018, 1698, (6), 3908-3922.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of 地索苯宁 as an Impurity". J. Agric. Food Chem., 2025, 1594, (12), 2671-2675.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of 65717-97-7 4V891LH5NB Disofenin [USAN:INN:BAN] Disofenin Glycine, N-(2-((2,6-bis(1-methylethyl)phenyl)amino)-2-oxoethyl)-N-(carboxymethyl)- ((((2,6-Diisopropylphenyl)carbamoyl)methyl)imino)diacetic acid Disofenine [INN-French] Disofenino [INN-Spanish] Disofeninum [INN-Latin] Disofenine Disofenino Disofeninum UNII-4V891LH5NB DSIDA Using HRMS and NMR". Biomed. Chromatogr., 2012, 1914, (9), 9514-9517.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate 地索苯宁 Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2022, 588, 4051-4075.

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