乙烯基膦酸二乙酯 CAS 682-30-4

682-30-4 KST-1A7519 [(2r,3s,4r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl(3r,4s,5s,6r)-3-fluoro-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl dihydrogen diphosphate(non-preferred name)

纯度 97%+现货药物标准品
CAS 号682-30-4
分子式C6H13O3P
分子量164.14 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

乙烯基膦酸二乙酯 682-30-4 KST-1A7519 [(2r,3s,4r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl(3r,4s,5s,6r)-3-fluoro-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl dihydrogen diphosphate(non-preferred name) CAS 682-30-4 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品乙烯基膦酸二乙酯（682-30-4 KST-1A7519 [(2r,3s,4r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl(3r,4s,5s,6r)-3-fluoro-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl dihydrogen diphosphate(non-preferred name)，CAS 682-30-4），分子式 C6H13O3P，分子量 164.14。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

乙烯基膦酸二乙酯（C6H13O3P）含有含膦酸基，羧酸类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。 化学式为 C6H13O3P 的乙烯基膦酸二乙酯（682-30-4 KST-1A7519 (2r,3s,4r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-ylmethyl(3r,4s,5s,6r)-3-fluoro-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl dihydrogen diphosphate(non-preferred name)），其CAS登记号是 682-30-4，分子量为 164.14 g/mol。 本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 在质量保证方面，乙烯基膦酸二乙酯的生产和定值严格遵循

应用场景：针对化学分析用途，乙烯基膦酸二乙酯（682-30-4 KST-1A7519 (2r,3s,4r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-yl methyl(3r,4s,5s,6r)-3-fluoro-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl dihydrogen diphosphate(non-preferred name)）是具有明确定量溯源的认证级对照品。 推荐以乙烯基膦酸二乙酯配制标准系列工作溶液，用于建

理化性质 Physical & Chemical Properties

中文名称乙烯基膦酸二乙酯
分子式C6H13O3P
分子量164.14 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）0.5
CAS登记年份（估）1957年

相关专利 Related Patents

  1. 发明人刘建华，郑宇鹏，赵玉洁. "一种乙烯基膦酸二乙酯的合成方法" [P]. 中国发明专利, 专利号 CN 109685225 B, 授权公告日 2016-04-05.
  2. 发明人赵玉洁，徐明华，沈红梅. "Method for the Synthesis of 682-30-4 KST-1A7519 [(2r,3s,4r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl(3r,4s,5s,6r)-3-fluoro-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl dihydrogen diphosphate(non-preferred name)" [P]. 中国发明专利, 专利号 CN 113208962 A, 授权公告日 2025-05-25.
  3. 发明人马晓峰，周伟，何建平. "A Process for Preparing High-Purity 682-30-4 KST-1A7519 [(2r,3s,4r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl(3r,4s,5s,6r)-3-fluoro-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl dihydrogen diphosphate(non-preferred name)" [P]. 中国发明专利, 专利号 CN 112759233 B, 授权公告日 2023-12-15.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 乙烯基膦酸二乙酯 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2025, 442, (2), 9579-9589.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 乙烯基膦酸二乙酯 as an Impurity". Anal. Chim. Acta, 2017, 341, 6326-6352.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 682-30-4 KST-1A7519 [(2r,3s,4r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl(3r,4s,5s,6r)-3-fluoro-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl dihydrogen diphosphate(non-preferred name) Using HRMS and NMR". Phytochemistry, 2014, 1946, (6), 1692-1697.

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