Trizma<SUP>®</SUP>乙酸盐 CAS 6850-28-8

1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium acetate 2-amino-2-(hydroxymethyl)propane-1,3-diol acetate 6850-28-8 CHEBI:66869 TRIS acetate salt [2-hydroxy-1,1-bis(hydroxymethyl)ethyl]ammonium acetate tris acetate tris(hydroxymethyl)aminomethane acetate tris(hydroxymethyl)aminomethane acetate salt trizma acetate

纯度 97%+现货药物标准品
CAS 号6850-28-8
分子式C4H11NO3 C2H4O2
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Trizma<SUP>®</SUP>乙酸盐 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium acetate 2-amino-2-(hydroxymethyl)propane-1,3-diol acetate 6850-28-8 CHEBI:66869 TRIS acetate salt [2-hydroxy-1,1-bis(hydroxymethyl)ethyl]ammonium acetate tris acetate tris(hydroxymethyl)aminomethane acetate tris(hydroxymethyl)aminomethane acetate salt trizma acetate CAS 6850-28-8 结构式 Chemical Structure

产品介绍 Description

Trizma<SUP>®</SUP>乙酸盐（英文名 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium acetate 2-amino-2-(hydroxymethyl)propane-1,3-diol acetate 6850-28-8 CHEBI:66869 TRIS acetate salt [2-hydroxy-1,1-bis(hydroxymethyl)ethyl]ammonium acetate tris acetate tris(hydroxymethyl)aminomethane acetate tris(hydroxymethyl)aminomethane acetate salt trizma acetate，CAS 6850-28-8）属于药物标准品。分子式 C4H11NO3 C2H4O2。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

Trizma<SUP>®</SUP>乙酸盐的产生途径与其化学式中糖类衍生物，酰胺类密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 6850-28-8 对应的化合物Trizma<SUP>®</SUP>乙酸盐（英文标识 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium acetate 2-amino-2-(hydroxymethyl)propane-1,3-diol acetate 6850-28-8 CHEBI:66869 TRIS acetate salt 2-hydroxy-1,1-bis(hydroxymethyl)ethylammonium acetate tris acetate tris(hydroxymethyl)aminomethane acetate tris(hydroxymethyl)aminomethane acetate salt trizma acetate），化学式 C4H11NO3 C2H4O2，相对分子质量 181.19。 受分子结构中糖类衍生物，酰胺类的影响，Tr

应用场景：Trizma<SUP>®</SUP>乙酸盐（1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium acetate 2-amino-2-(hydroxymethyl)propane-1,3-diol acetate 6850-28-8 CHEBI:66869 TRIS acetate salt 2-hydroxy-1,1-bis(hydroxymethyl)ethyl ammonium acetate tris acetate tris(hydroxymethyl)aminomethane acetate tris(hydroxymethyl)amin

理化性质 Physical & Chemical Properties

中文名称Trizma<SUP>®</SUP>乙酸盐
分子式C4H11NO3 C2H4O2
分子量181.19 g/mol
外观形态白色至类白色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）0.0
CAS登记年份（估）1958年
含氮原子数1

相关专利 Related Patents

  1. 发明人胡光，高志强，马晓峰. "一种Trizma<SUP>®</SUP>乙酸盐的合成方法" [P]. 中国发明专利, 专利号 CN 111200770 B, 授权公告日 2018-12-02.
  2. 发明人高志强，胡光，赵玉洁. "Method for the Synthesis of 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium acetate 2-amino-2-(hydroxymethyl)propane-1,3-diol acetate 6850-28-8 CHEBI:66869 TRIS acetate salt [2-hydroxy-1,1-bis(hydroxymethyl)ethyl]ammonium acetate tris acetate tris(hydroxymethyl)aminomethane acetate tris(hydroxymethyl)aminomethane acetate salt trizma acetate" [P]. 中国发明专利, 专利号 CN 108222183 B, 授权公告日 2024-09-07.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of Trizma<SUP>®</SUP>乙酸盐 in Pharmaceutical Formulations". Chromatographia, 2021, 1437, (7), 1609-1623.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of Trizma<SUP>®</SUP>乙酸盐 as an Impurity". Anal. Chem., 2023, 371, (2), 7956-7978.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium acetate 2-amino-2-(hydroxymethyl)propane-1,3-diol acetate 6850-28-8 CHEBI:66869 TRIS acetate salt [2-hydroxy-1,1-bis(hydroxymethyl)ethyl]ammonium acetate tris acetate tris(hydroxymethyl)aminomethane acetate tris(hydroxymethyl)aminomethane acetate salt trizma acetate Using HRMS and NMR". J. Sep. Sci., 2018, 1147, 5879-5884.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate Trizma<SUP>®</SUP>乙酸盐 Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2024, 1905, 3418-3425.

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