3-(三氟甲基)氯苄 CAS 705-29-3

3-(Trifluoromethyl)benzyl chloride 1-chloromethyl-3-trifluoromethyl-benzene 3-(trifluoromethyl)-benzyl chloride m-trifluoromethylbenzyl chloride alpha-chloro-alpha',alpha',alpha'-trifluoro-m-xylene alpha'-chloro-alpha,alpha,alpha-trifluoro-m-xylene alpha'-chloro-alpha alpha alpha-trifluoro-m-xylene 3-chloromethyl-benzotrifluoride m-trifluoromethyl benzyl chloride 1-(chloromethyl)-3-(trifluoromethyl)benzene 3-trifluoromethylbenzyl chloride m-(trifluoromethyl)benzyl chloride 705-29-3

纯度 97%+现货药物标准品
CAS 号705-29-3
分子式C8H12ClF3
分子量200.63 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-(三氟甲基)氯苄 3-(Trifluoromethyl)benzyl chloride 1-chloromethyl-3-trifluoromethyl-benzene 3-(trifluoromethyl)-benzyl chloride m-trifluoromethylbenzyl chloride alpha-chloro-alpha',alpha',alpha'-trifluoro-m-xylene alpha'-chloro-alpha,alpha,alpha-trifluoro-m-xylene alpha'-chloro-alpha alpha alpha-trifluoro-m-xylene 3-chloromethyl-benzotrifluoride m-trifluoromethyl benzyl chloride 1-(chloromethyl)-3-(trifluoromethyl)benzene 3-trifluoromethylbenzyl chloride m-(trifluoromethyl)benzyl chloride 705-29-3 CAS 705-29-3 结构式 Chemical Structure

产品介绍 Description

3-(三氟甲基)氯苄（3-(Trifluoromethyl)benzyl chloride 1-chloromethyl-3-trifluoromethyl-benzene 3-(trifluoromethyl)-benzyl chloride m-trifluoromethylbenzyl chloride alpha-chloro-alpha',alpha',alpha'-trifluoro-m-xylene alpha'-chloro-alpha,alpha,alpha-trifluoro-m-xylene alpha'-chloro-alpha alpha alpha-trifluoro-m-xylene 3-chloromethyl-benzotrifluoride m-trifluoromethyl benzyl chloride 1-(chloromethyl)-3-(trifluoromethyl)benzene 3-trifluoromethylbenzyl chloride m-(trifluoromethyl)benzyl chloride 705-29-3）是药物分析与质量控制领域常用的药物标准品，CAS 号 705-29-3。分子式 C8H12ClF3，分子量 200.63。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括3-(三氟甲基)氯苄在内的目标物的控制。 化学式为 C8H12ClF3 的3-(三氟甲基)氯苄（3-(Trifluoromethyl)benzyl chloride 1-chloromethyl-3-trifluoromethyl-benzene 3-(trifluoromethyl)-benzyl chloride m-trifluoromethylbenzyl chloride alpha-chloro-alpha',alpha',alpha'-trifluoro-m-xylene alpha'-chloro-alpha,alpha,alpha-trifluoro-m-xylene alpha'-chloro-alpha alpha alpha-trifluoro-m-xylene 3-chloromethyl-benzotrifluoride m-trifluoromethyl benzyl chloride 1-(chloromethyl)-3-(trifluoromethyl)benzene 3-trifluoro

应用场景：从实际应用出发，3-(三氟甲基)氯苄（CAS 705-29-3）在化学分析中作为关键的基准对照物质。 推荐以3-(三氟甲基)氯苄配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于室温保存，密闭保存防止挥发条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称3-(三氟甲基)氯苄
分子式C8H12ClF3
分子量200.63 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1957年
卤素含量F/Cl取代

相关专利 Related Patents

  1. Klinger H, O'Brien P Q, Stevens L M. "一种3-(三氟甲基)氯苄的合成方法" [P]. US Patent, US 11173599 B2, 2019-08-10.
  2. 发明人钱学锋，刘建华，朱建伟. "Method for the Synthesis of 3-(Trifluoromethyl)benzyl chloride 1-chloromethyl-3-trifluoromethyl-benzene 3-(trifluoromethyl)-benzyl chloride m-trifluoromethylbenzyl chloride alpha-chloro-alpha',alpha',alpha'-trifluoro-m-xylene alpha'-chloro-alpha,alpha,alpha-trifluoro-m-xylene alpha'-chloro-alpha alpha alpha-trifluoro-m-xylene 3-chloromethyl-benzotrifluoride m-trifluoromethyl benzyl chloride 1-(chloromethyl)-3-(trifluoromethyl)benzene 3-trifluoromethylbenzyl chloride m-(trifluoromethyl)benzyl chloride 705-29-3" [P]. 中国发明专利, 专利号 CN 116235397 B, 授权公告日 2023-02-04.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 3-(三氟甲基)氯苄 in Pharmaceutical Formulations". Talanta, 2012, 345, 6332-6352.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-(三氟甲基)氯苄 as an Impurity". J. Pharm. Biomed. Anal., 2024, 617, 6022-6034.

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