Conglobatin CAS 72263-05-9
72263-05-9 Conglobatin 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 8,16-bis(5-oxazolylmethyl)-3,5,7,11,13,15-hexamethyl-, (5R-(3E,5R*,7S*,8S*,11E,13R*,15S*,16S*))- 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (5S-(3E,5R*,7S*,8S*,11E,13R*,15S*,16S*))- BRN 5321648
| CAS 号 | 72263-05-9 |
| 分子式 | C28H38N2O6 |
| 分子量 | 498.61 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品Conglobatin（72263-05-9 Conglobatin 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 8,16-bis(5-oxazolylmethyl)-3,5,7,11,13,15-hexamethyl-, (5R-(3E,5R*,7S*,8S*,11E,13R*,15S*,16S*))- 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (5S-(3E,5R*,7S*,8S*,11E,13R*,15S*,16S*))- BRN 5321648，CAS 72263-05-9），分子式 C28H38N2O6，分子量 498.61。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
与同类药物标准品相比，Conglobatin的分子量为498.61 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C28H38N2O6 的Conglobatin（72263-05-9 Conglobatin 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 8,16-bis(5-oxazolylmethyl)-3,5,7,11,13,15-hexamethyl-, (5R-(3E,5R,7S,8S,11E,13R,15S,16S))- 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (5S-(3E,5R,7S,8S,11E,13R,15S,16S))- BRN 5321648），其CAS登记号是 72263-05-9，分子量为 498.61 g/mol。 Conglobatin（C28H38N2O6）含有甾体骨架，酰胺类，含羟基，含
应用场景：Conglobatin（72263-05-9 Conglobatin 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 8,16-bis(5-oxazolylmethyl)-3,5,7,11,13,15-hexamethyl-, (5R-(3E,5R ,7S ,8S ,11E,13R ,15S ,16S ))- 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (5S-(3E,5R ,7S ,8S ,1
理化性质 Physical & Chemical Properties
| 中文名称 | Conglobatin |
| 分子式 | C28H38N2O6 |
| 分子量 | 498.61 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 11.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1977年 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- Nowak P, Björnsson E, Nielsen H. "一种Conglobatin的合成方法" [P]. European Patent, EP 3359425 A1, 2016-06-09.
- Davis P L, Klinger H, Yamamoto T. "Method for the Synthesis of 72263-05-9 Conglobatin 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 8,16-bis(5-oxazolylmethyl)-3,5,7,11,13,15-hexamethyl-, (5R-(3E,5R*,7S*,8S*,11E,13R*,15S*,16S*))- 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (5S-(3E,5R*,7S*,8S*,11E,13R*,15S*,16S*))- BRN 5321648" [P]. US Patent, US 10551483 B2, 2015-08-19.
- Schröder R, Yamamoto T, Lee S K. "A Process for Preparing High-Purity 72263-05-9 Conglobatin 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 8,16-bis(5-oxazolylmethyl)-3,5,7,11,13,15-hexamethyl-, (5R-(3E,5R*,7S*,8S*,11E,13R*,15S*,16S*))- 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (5S-(3E,5R*,7S*,8S*,11E,13R*,15S*,16S*))- BRN 5321648" [P]. US Patent, US 11408014 B2, 2025-10-21.
参考文献 Literature
- Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of Conglobatin in Pharmaceutical Formulations". J. Sep. Sci., 2011, 2359, (3), 8223-8251.
- Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of Conglobatin as an Impurity". Molecules, 2016, 681, (6), 4729-4745.
- Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 72263-05-9 Conglobatin 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 8,16-bis(5-oxazolylmethyl)-3,5,7,11,13,15-hexamethyl-, (5R-(3E,5R*,7S*,8S*,11E,13R*,15S*,16S*))- 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (5S-(3E,5R*,7S*,8S*,11E,13R*,15S*,16S*))- BRN 5321648 Using HRMS and NMR". Anal. Methods, 2016, 1370, (8), 9673-9698.
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