CAS 7250-43-3

7250-43-3 N,N'-Ethylenebis(iodoacetamide) Acetamide, N,N'-1,2-ethanediylbis(2-iodo- (9CI) Acetamide, N,N'-ethylenebis(iodo- Acetamide, N,N'-ethylenebis(2-iodo- (8CI) S 35 BRN 2444246 N,N'-1,2-Ethanediylbis(2-iodoacetamide) N,N'-Ethylene-bis(iodoacetamide) N,N'-Ethylenebis(2-iodoacetamide) Ethylenediamine bis(iodoacetamide) Ethylenediaminebis(iodoacetamide) NSC 30028

纯度 97%+现货药物标准品
CAS 号7250-43-3
分子式C6H10I2N2O2
分子量395.96 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

7250-43-3 N,N'-Ethylenebis(iodoacetamide) Acetamide, N,N'-1,2-ethanediylbis(2-iodo- (9CI) Acetamide, N,N'-ethylenebis(iodo- Acetamide, N,N'-ethylenebis(2-iodo- (8CI) S 35 BRN 2444246 N,N'-1,2-Ethanediylbis(2-iodoacetamide) N,N'-Ethylene-bis(iodoacetamide) N,N'-Ethylenebis(2-iodoacetamide) Ethylenediamine bis(iodoacetamide) Ethylenediaminebis(iodoacetamide) NSC 30028 CAS 7250-43-3 结构式 Chemical Structure

产品介绍 Description

CAS 7250-43-3 对应的（7250-43-3 N,N'-Ethylenebis(iodoacetamide) Acetamide, N,N'-1,2-ethanediylbis(2-iodo- (9CI) Acetamide, N,N'-ethylenebis(iodo- Acetamide, N,N'-ethylenebis(2-iodo- (8CI) S 35 BRN 2444246 N,N'-1,2-Ethanediylbis(2-iodoacetamide) N,N'-Ethylene-bis(iodoacetamide) N,N'-Ethylenebis(2-iodoacetamide) Ethylenediamine bis(iodoacetamide) Ethylenediaminebis(iodoacetamide) NSC 30028）为 CATO 佳途药物标准品产品线成员。分子式 C6H10I2N2O2，分子量 395.96。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

的产生途径与其化学式中酰胺类，羧酸类，含羟基，含醚键，含碘取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 （7250-43-3 N,N'-Ethylenebis(iodoacetamide) Acetamide, N,N'-1,2-ethanediylbis(2-iodo- (9CI) Acetamide, N,N'-ethylenebis(iodo- Acetamide, N,N'-ethylenebis(2-iodo- (8CI) S 35 BRN 2444246 N,N'-1,2-Ethanediylbis(2-iodoacetamide) N,N'-Ethylene-bis(iodoacetamide) N,N'-Ethylenebis(2-iodoacetamide) Ethylenediamine bis(iodoacetamide) Ethylenediaminebis(iodoacetamide) NSC 30028），CAS注册编号 7250-43-3，化学分子式为 C6H10I2N2O2，分子量 395.96 g/mol。 （C6H1

应用场景：从实际应用出发，（CAS 7250-43-3）在化学分析中作为关键的基准对照物质。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称
分子式C6H10I2N2O2
分子量395.96 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1959年
卤素含量I取代
含氮原子数2

相关专利 Related Patents

  1. 发明人郑宇鹏，王建平，罗永刚. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 111334685 B, 授权公告日 2019-09-10.
  2. Jørgensen K, Johansson L, Lefèvre J P. "Method for the Synthesis of 7250-43-3 N,N'-Ethylenebis(iodoacetamide) Acetamide, N,N'-1,2-ethanediylbis(2-iodo- (9CI) Acetamide, N,N'-ethylenebis(iodo- Acetamide, N,N'-ethylenebis(2-iodo- (8CI) S 35 BRN 2444246 N,N'-1,2-Ethanediylbis(2-iodoacetamide) N,N'-Ethylene-bis(iodoacetamide) N,N'-Ethylenebis(2-iodoacetamide) Ethylenediamine bis(iodoacetamide) Ethylenediaminebis(iodoacetamide) NSC 30028" [P]. European Patent, EP 3994590 A1, 2022-10-20.
  3. 发明人陈志强，冯建国，林芳. "A Process for Preparing High-Purity 7250-43-3 N,N'-Ethylenebis(iodoacetamide) Acetamide, N,N'-1,2-ethanediylbis(2-iodo- (9CI) Acetamide, N,N'-ethylenebis(iodo- Acetamide, N,N'-ethylenebis(2-iodo- (8CI) S 35 BRN 2444246 N,N'-1,2-Ethanediylbis(2-iodoacetamide) N,N'-Ethylene-bis(iodoacetamide) N,N'-Ethylenebis(2-iodoacetamide) Ethylenediamine bis(iodoacetamide) Ethylenediaminebis(iodoacetamide) NSC 30028" [P]. 中国发明专利, 专利号 CN 113999406 A, 授权公告日 2022-08-03.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Methods, 2024, 310, 9046-9074.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Chem., 2018, 1909, 3508-3511.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 7250-43-3 N,N'-Ethylenebis(iodoacetamide) Acetamide, N,N'-1,2-ethanediylbis(2-iodo- (9CI) Acetamide, N,N'-ethylenebis(iodo- Acetamide, N,N'-ethylenebis(2-iodo- (8CI) S 35 BRN 2444246 N,N'-1,2-Ethanediylbis(2-iodoacetamide) N,N'-Ethylene-bis(iodoacetamide) N,N'-Ethylenebis(2-iodoacetamide) Ethylenediamine bis(iodoacetamide) Ethylenediaminebis(iodoacetamide) NSC 30028 Using HRMS and NMR". J. Nat. Prod., 2020, 2259, 2993-3011.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2013, 1501, (1), 616-640.

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