(<I>R</I>)-(-)-3-羟基-2-甲基丙酸甲酯 CAS 72657-23-9

(-)-Methyl D-|A-hydroxyisobutyrate (-)-Methyl |A-Hydroxyisobutyrate (2R)-3-Hydroxy-2-methylpropionic Acid Methyl Ester (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester (R)-3-Hydroxyisobutyric Acid Methyl Ester 72657-23-9 Methyl (R)-(-)-3-hydroxy-2-methylpropionate Methyl (R)-3-hydroxy-2-methylpropionate R-(-)-Roche Ester

纯度 97%+现货药物标准品
CAS 号72657-23-9
分子式C5H10O3
分子量118.13 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>R</I>)-(-)-3-羟基-2-甲基丙酸甲酯 (-)-Methyl D-|A-hydroxyisobutyrate (-)-Methyl |A-Hydroxyisobutyrate (2R)-3-Hydroxy-2-methylpropionic Acid Methyl Ester (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester (R)-3-Hydroxyisobutyric Acid Methyl Ester 72657-23-9 Methyl (R)-(-)-3-hydroxy-2-methylpropionate Methyl (R)-3-hydroxy-2-methylpropionate R-(-)-Roche Ester CAS 72657-23-9 结构式 Chemical Structure

产品介绍 Description

(<I>R</I>)-(-)-3-羟基-2-甲基丙酸甲酯（(-)-Methyl D-|A-hydroxyisobutyrate (-)-Methyl |A-Hydroxyisobutyrate (2R)-3-Hydroxy-2-methylpropionic Acid Methyl Ester (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester (R)-3-Hydroxyisobutyric Acid Methyl Ester 72657-23-9 Methyl (R)-(-)-3-hydroxy-2-methylpropionate Methyl (R)-3-hydroxy-2-methylpropionate R-(-)-Roche Ester，CAS 号 72657-23-9）是 CATO 佳途自主生产的药物标准品，分子式 C5H10O3，分子量 118.13。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括(<I>R</I>)-(-)-3-羟基-2-甲基丙酸甲酯在内的目标物的控制。 (<I>R</I>)-(-)-3-羟基-2-甲基丙酸甲酯（(-)-Methyl D-|A-hydroxyisobutyrate (-)-Methyl |A-Hydroxyisobutyrate (2R)-3-Hydroxy-2-methylpropionic Acid Methyl Ester (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester (R)-3-Hydroxyisobutyric Acid Methyl Ester 72657-23-9 Methyl (R)-(-)-3-hydroxy-2-methylpropionate Methyl (R)-3-hydroxy-2-methylpropionate R-(-)-Roche Ester），CAS注册编号 72657-23-9，化学分子式为 C5H10O3，分子量 118.13 g/mol。 从化学结构特征来看，(<I>R</I>

应用场景：(<I>R</I>)-(-)-3-羟基-2-甲基丙酸甲酯（(-)-Methyl D-|A-hydroxyisobutyrate (-)-Methyl |A-Hydroxyisobutyrate (2R)-3-Hydroxy-2-methylpropionic Acid Methyl Ester (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester (R)-3-Hydroxyisobutyric Acid Methyl Ester 72657-23-9 Methyl (R)-(-)-3-hydroxy-2-methylpropionate M

理化性质 Physical & Chemical Properties

中文名称(<I>R</I>)-(-)-3-羟基-2-甲基丙酸甲酯
分子式C5H10O3
分子量118.13 g/mol
外观形态白色至类白色液体
纯度97%+
储存条件2-8°C冷藏保存，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1977年

相关专利 Related Patents

  1. 发明人徐明华，罗永刚，陈志强. "一种(<I>R</I>)-(-)-3-羟基-2-甲基丙酸甲酯的合成方法" [P]. 中国发明专利, 专利号 CN 110338752 B, 授权公告日 2021-08-27.
  2. 发明人沈红梅，赵玉洁，黄志刚. "Method for the Synthesis of (-)-Methyl D-|A-hydroxyisobutyrate (-)-Methyl |A-Hydroxyisobutyrate (2R)-3-Hydroxy-2-methylpropionic Acid Methyl Ester (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester (R)-3-Hydroxyisobutyric Acid Methyl Ester 72657-23-9 Methyl (R)-(-)-3-hydroxy-2-methylpropionate Methyl (R)-3-hydroxy-2-methylpropionate R-(-)-Roche Ester" [P]. 中国发明专利, 专利号 CN 110179296 A, 授权公告日 2018-11-19.
  3. 发明人冯建国，唐晓军，林芳. "A Process for Preparing High-Purity (-)-Methyl D-|A-hydroxyisobutyrate (-)-Methyl |A-Hydroxyisobutyrate (2R)-3-Hydroxy-2-methylpropionic Acid Methyl Ester (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester (R)-3-Hydroxyisobutyric Acid Methyl Ester 72657-23-9 Methyl (R)-(-)-3-hydroxy-2-methylpropionate Methyl (R)-3-hydroxy-2-methylpropionate R-(-)-Roche Ester" [P]. 中国发明专利, 专利号 CN 112765033 A, 授权公告日 2022-02-21.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>R</I>)-(-)-3-羟基-2-甲基丙酸甲酯 in Pharmaceutical Formulations". Phytochemistry, 2020, 1273, 6479-6487.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>R</I>)-(-)-3-羟基-2-甲基丙酸甲酯 as an Impurity". Anal. Chim. Acta, 2022, 1573, 3382-3401.

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