1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid CAS 731801-16-4

1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid

纯度 97%+现货药物标准品
CAS 号731801-16-4
分子式C17H21N5O4S
分子量391.44 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid 1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid CAS 731801-16-4 结构式 Chemical Structure

产品介绍 Description

1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid（1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid）是药物分析与质量控制领域常用的药物标准品，CAS 号 731801-16-4。分子式 C17H21N5O4S，分子量 391.44。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括1-({1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-ylthio}acetyl)piperidine-4-carboxylic acid在内的目标物的控制。 化学式为 C17H21N5O4S 的1-({1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-ylthio}acetyl)piperidine-4-carboxylic acid（1-({1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-ylthio}acetyl)piperidine-4-carboxylic acid），其CAS登记号是 731801-16-4，分子量为 391.44 g/mol。 1-({1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-ylthio}acetyl)piperidine-4-carboxylic acid（分子式 C17H21N5O4S）的化学结构中包含黄酮骨架，酰胺

应用场景：针对化学分析用途，1-({ 1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl thio}acetyl)piperidine-4-carboxylic acid（1-({ 1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl thio}acetyl)piperidine-4-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以1-({ 1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl thio}acetyl)piperidine-4-carboxyli

理化性质 Physical & Chemical Properties

中文名称1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid
分子式C17H21N5O4S
分子量391.44 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年
含氮原子数5
含硫原子数1

相关专利 Related Patents

  1. 发明人孙丽萍，沈红梅，李文辉. "一种1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 109405696 B, 授权公告日 2023-03-13.
  2. 发明人朱建伟，刘建华，唐晓军. "Method for the Synthesis of 1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid" [P]. 中国发明专利, 专利号 CN 112129970 A, 授权公告日 2025-06-24.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid in Pharmaceutical Formulations". Environ. Sci. Technol., 2024, 1066, (5), 4729-4753.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid as an Impurity". Anal. Chem., 2021, 837, (8), 879-896.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of 1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid Using HRMS and NMR". Phytochemistry, 2020, 1802, (1), 685-707.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate 1-({[1-(2-methoxy-5-methylphenyl)-1H-tetrazol-5-yl]thio}acetyl)piperidine-4-carboxylic acid Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2016, 465, 4610-4637.

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