1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-(三氟甲基)嘧啶-2,4(1H,3H)-二酮 5-氯-6-((2-亚氨基吡咯烷-1-基)甲基)嘧啶-2,4(1H,3H)二酮盐酸盐(1:1) CAS 733030-01-8

1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione mixt. with 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione (1:1) hydrochloride

纯度 97%+现货药物标准品
CAS 号733030-01-8
分子式C10H11F3N2O5 C9H11ClN4O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-(三氟甲基)嘧啶-2,4(1H,3H)-二酮 5-氯-6-((2-亚氨基吡咯烷-1-基)甲基)嘧啶-2,4(1H,3H)二酮盐酸盐(1:1) 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione mixt. with 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione (1:1) hydrochloride CAS 733030-01-8 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-(三氟甲基)嘧啶-2,4(1H,3H)-二酮 5-氯-6-((2-亚氨基吡咯烷-1-基)甲基)嘧啶-2,4(1H,3H)二酮盐酸盐(1:1)（1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione mixt. with 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione (1:1) hydrochloride）为药物标准品，CAS 登记号 733030-01-8，分子式 C10H11F3N2O5 C9H11ClN4O2 HCl。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-(三氟甲基)嘧啶-2,4(1H,3H)-二酮 5-氯-6-((2-亚氨基吡咯烷-1-基)甲基)嘧啶-2,4(1H,3H)二酮盐酸盐(1:1)（1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione mixt. with 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione (1:1) hydrochloride），CAS注册编号 733030-01-8，化学分子式为 C10H11F3N2O5 C9H11ClN4O2 HCl，分子量 575.32 g/mol。 1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-(三氟甲基)嘧啶-2,4(1H,3H)-二酮 5-氯-6-((2-亚氨基吡咯烷-1-基)甲基)嘧啶-2,4(1H,3H)二酮盐酸盐

应用场景：针对化学分析用途，1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-(三氟甲基)嘧啶-2,4(1H,3H)-二酮 5-氯-6-((2-亚氨基吡咯烷-1-基)甲基)嘧啶-2,4(1H,3H)二酮盐酸盐(1:1)（1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione mixt. with 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,

理化性质 Physical & Chemical Properties

中文名称1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-(三氟甲基)嘧啶-2,4(1H,3H)-二酮 5-氯-6-((2-亚氨基吡咯烷-1-基)甲基)嘧啶-2,4(1H,3H)二酮盐酸盐(1:1)
分子式C10H11F3N2O5 C9H11ClN4O2 HCl
分子量575.32 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年
卤素含量F/Cl取代
含氮原子数6

相关专利 Related Patents

  1. 发明人冯建国，徐明华，韩伟. "一种1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-(三氟甲基)嘧啶-2,4(1H,3H)-二酮 5-氯-6-((2-亚氨基吡咯烷-1-基)甲基)嘧啶-2,4(1H,3H)二酮盐酸盐(1:1)的合成方法" [P]. 中国发明专利, 专利号 CN 108137667 A, 授权公告日 2024-01-10.
  2. Hughes D C, Kumar R, Johnson M A. "Method for the Synthesis of 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione mixt. with 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione (1:1) hydrochloride" [P]. US Patent, US 10396570 B2, 2022-06-22.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-(三氟甲基)嘧啶-2,4(1H,3H)-二酮 5-氯-6-((2-亚氨基吡咯烷-1-基)甲基)嘧啶-2,4(1H,3H)二酮盐酸盐(1:1) in Pharmaceutical Formulations". Environ. Sci. Technol., 2015, 187, 3705-3731.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-(三氟甲基)嘧啶-2,4(1H,3H)-二酮 5-氯-6-((2-亚氨基吡咯烷-1-基)甲基)嘧啶-2,4(1H,3H)二酮盐酸盐(1:1) as an Impurity". Molecules, 2016, 1908, 965-974.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione mixt. with 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione (1:1) hydrochloride Using HRMS and NMR". J. Nat. Prod., 2014, 907, (4), 4814-4831.

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