甲氧基聚乙二醇琥珀酸酯<I>N</I>-羟基琥珀酰亚胺 CAS 78274-32-5

LI74H4DD8X A80OP59PIG LTP4ZS35DJ S75YD33U2H 94I49D1SZD 78274-32-5 Methoxypolyethylene glycol succinimidylsuccinate Poly(oxy-1,2-ethanediyl), alpha-(4-((2,5-dioxo-1-pyrrolidinyl)oxy)-1,4-dioxobutyl)-omega-methoxy ss-Peg UNII-LI74H4DD8X UNII-A80OP59PIG UNII-LTP4ZS35DJ UNII-S75YD33U2H UNII-94I49D1SZD

纯度 97%+现货药物标准品
CAS 号78274-32-5
分子式C11H15NO7
分子量273.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

甲氧基聚乙二醇琥珀酸酯<I>N</I>-羟基琥珀酰亚胺 LI74H4DD8X A80OP59PIG LTP4ZS35DJ S75YD33U2H 94I49D1SZD 78274-32-5 Methoxypolyethylene glycol succinimidylsuccinate Poly(oxy-1,2-ethanediyl), alpha-(4-((2,5-dioxo-1-pyrrolidinyl)oxy)-1,4-dioxobutyl)-omega-methoxy ss-Peg UNII-LI74H4DD8X UNII-A80OP59PIG UNII-LTP4ZS35DJ UNII-S75YD33U2H UNII-94I49D1SZD CAS 78274-32-5 结构式 Chemical Structure

产品介绍 Description

甲氧基聚乙二醇琥珀酸酯<I>N</I>-羟基琥珀酰亚胺（LI74H4DD8X A80OP59PIG LTP4ZS35DJ S75YD33U2H 94I49D1SZD 78274-32-5 Methoxypolyethylene glycol succinimidylsuccinate Poly(oxy-1,2-ethanediyl), alpha-(4-((2,5-dioxo-1-pyrrolidinyl)oxy)-1,4-dioxobutyl)-omega-methoxy ss-Peg UNII-LI74H4DD8X UNII-A80OP59PIG UNII-LTP4ZS35DJ UNII-S75YD33U2H UNII-94I49D1SZD，CAS 号 78274-32-5）是 CATO 佳途自主生产的药物标准品，分子式 C11H15NO7，分子量 273.24。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

CAS编号 78274-32-5 对应的化合物甲氧基聚乙二醇琥珀酸酯<I>N</I>-羟基琥珀酰亚胺（英文标识 LI74H4DD8X A80OP59PIG LTP4ZS35DJ S75YD33U2H 94I49D1SZD 78274-32-5 Methoxypolyethylene glycol succinimidylsuccinate Poly(oxy-1,2-ethanediyl), alpha-(4-((2,5-dioxo-1-pyrrolidinyl)oxy)-1,4-dioxobutyl)-omega-methoxy ss-Peg UNII-LI74H4DD8X UNII-A80OP59PIG UNII-LTP4ZS35DJ UNII-S75YD33U2H UNII-94I49D1SZD），化学式 C11H15NO7，相对分子质量 273.24。 依据分子式为 C11H15NO7 的甲氧基聚乙二醇琥珀酸酯<I>N</I>-羟基琥珀酰亚胺结构特征，其分子内含氨基酸衍生物，酰胺类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 273.24 g/mo

应用场景：针对化学分析用途，甲氧基聚乙二醇琥珀酸酯<I>N</I>-羟基琥珀酰亚胺（LI74H4DD8X A80OP59PIG LTP4ZS35DJ S75YD33U2H 94I49D1SZD 78274-32-5 Methoxypolyethylene glycol succinimidylsuccinate Poly(oxy-1,2-ethanediyl), alpha-(4-((2,5-dioxo-1-pyrrolidinyl)oxy)-1,4-dioxobutyl)-omega-methoxy ss-Peg UNII-LI74H4DD8X UNII-A80OP59PIG UNII-LTP4ZS3

理化性质 Physical & Chemical Properties

中文名称甲氧基聚乙二醇琥珀酸酯<I>N</I>-羟基琥珀酰亚胺
分子式C11H15NO7
分子量273.24 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1979年
含氮原子数1

相关专利 Related Patents

  1. 发明人赵玉洁，陈志强，徐明华. "一种甲氧基聚乙二醇琥珀酸酯<I>N</I>-羟基琥珀酰亚胺的合成方法" [P]. 中国发明专利, 专利号 CN 116045482 B, 授权公告日 2018-06-03.
  2. Martínez F, Kowalski A, Rossi M. "Method for the Synthesis of LI74H4DD8X A80OP59PIG LTP4ZS35DJ S75YD33U2H 94I49D1SZD 78274-32-5 Methoxypolyethylene glycol succinimidylsuccinate Poly(oxy-1,2-ethanediyl), alpha-(4-((2,5-dioxo-1-pyrrolidinyl)oxy)-1,4-dioxobutyl)-omega-methoxy ss-Peg UNII-LI74H4DD8X UNII-A80OP59PIG UNII-LTP4ZS35DJ UNII-S75YD33U2H UNII-94I49D1SZD" [P]. European Patent, EP 3258744 A1, 2019-03-20.
  3. Björnsson E, Kowalski A, Nielsen H. "A Process for Preparing High-Purity LI74H4DD8X A80OP59PIG LTP4ZS35DJ S75YD33U2H 94I49D1SZD 78274-32-5 Methoxypolyethylene glycol succinimidylsuccinate Poly(oxy-1,2-ethanediyl), alpha-(4-((2,5-dioxo-1-pyrrolidinyl)oxy)-1,4-dioxobutyl)-omega-methoxy ss-Peg UNII-LI74H4DD8X UNII-A80OP59PIG UNII-LTP4ZS35DJ UNII-S75YD33U2H UNII-94I49D1SZD" [P]. European Patent, EP 3178597 A1, 2025-12-21.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 甲氧基聚乙二醇琥珀酸酯<I>N</I>-羟基琥珀酰亚胺 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2020, 2013, (5), 3071-3086.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 甲氧基聚乙二醇琥珀酸酯<I>N</I>-羟基琥珀酰亚胺 as an Impurity". Chromatographia, 2010, 1179, (11), 7893-7901.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of LI74H4DD8X A80OP59PIG LTP4ZS35DJ S75YD33U2H 94I49D1SZD 78274-32-5 Methoxypolyethylene glycol succinimidylsuccinate Poly(oxy-1,2-ethanediyl), alpha-(4-((2,5-dioxo-1-pyrrolidinyl)oxy)-1,4-dioxobutyl)-omega-methoxy ss-Peg UNII-LI74H4DD8X UNII-A80OP59PIG UNII-LTP4ZS35DJ UNII-S75YD33U2H UNII-94I49D1SZD Using HRMS and NMR". J. Agric. Food Chem., 2014, 485, 4781-4791.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 甲氧基聚乙二醇琥珀酸酯<I>N</I>-羟基琥珀酰亚胺 Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2018, 1505, 7824-7847.

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