1,4-环己二酮-2,5-二甲酸二乙酯 CAS 787-07-5

787-07-5 Ethyl succinylsuccinate 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, 1,4-diethyl ester 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, diethyl ester AI3-16357 2,5-Bis(ethoxycarbonyl)-1,4-cyclohexanedione 1,4-Cyclohexanedione-2,5-dicarboxylic acid, diethyl ester 2,5-Dicarbethoxy-1,4-cyclohexanedione Diethyl 1,4-cyclohexanedione-2,5-dicarboxylate Diethyl 1,4-dioxo-2,5-cyclohexanedicarboxylate Diethyl 2,5-dioxo-1,4-cyclohexanedicarboxylate Diethyl succinosuccinate Diethyl succinylo succinate Diethyl succinylsuccinate EINECS 212-327-8 NSC 1140 NSC 130894 Succinylsuccinic acid ethyl ester

纯度 97%+现货药物标准品
CAS 号787-07-5
分子式C12H16O6
分子量256.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1,4-环己二酮-2,5-二甲酸二乙酯 787-07-5 Ethyl succinylsuccinate 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, 1,4-diethyl ester 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, diethyl ester AI3-16357 2,5-Bis(ethoxycarbonyl)-1,4-cyclohexanedione 1,4-Cyclohexanedione-2,5-dicarboxylic acid, diethyl ester 2,5-Dicarbethoxy-1,4-cyclohexanedione Diethyl 1,4-cyclohexanedione-2,5-dicarboxylate Diethyl 1,4-dioxo-2,5-cyclohexanedicarboxylate Diethyl 2,5-dioxo-1,4-cyclohexanedicarboxylate Diethyl succinosuccinate Diethyl succinylo succinate Diethyl succinylsuccinate EINECS 212-327-8 NSC 1140 NSC 130894 Succinylsuccinic acid ethyl ester CAS 787-07-5 结构式 Chemical Structure

产品介绍 Description

CAS 787-07-5 对应的1,4-环己二酮-2,5-二甲酸二乙酯（787-07-5 Ethyl succinylsuccinate 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, 1,4-diethyl ester 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, diethyl ester AI3-16357 2,5-Bis(ethoxycarbonyl)-1,4-cyclohexanedione 1,4-Cyclohexanedione-2,5-dicarboxylic acid, diethyl ester 2,5-Dicarbethoxy-1,4-cyclohexanedione Diethyl 1,4-cyclohexanedione-2,5-dicarboxylate Diethyl 1,4-dioxo-2,5-cyclohexanedicarboxylate Diethyl 2,5-dioxo-1,4-cyclohexanedicarboxylate Diethyl succinosuccinate Diethyl succinylo succinate Diethyl succinylsuccinate EINECS 212-327-8 NSC 1140 NSC 130894 Succinylsuccinic acid ethyl ester）为 CATO 佳途药物标准品产品线成员。分子式 C12H16O6，分子量 256.25。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括1,4-环己二酮-2,5-二甲酸二乙酯在内的目标物的控制。 CAS编号 787-07-5 对应的化合物1,4-环己二酮-2,5-二甲酸二乙酯（英文标识 787-07-5 Ethyl succinylsuccinate 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, 1,4-diethyl ester 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, diethyl ester AI3-16357 2,5-Bis(ethoxycarbonyl)-1,4-cyclohexanedione 1,4-Cyclohexanedione-2,5-dicarboxylic acid, diethyl ester 2,5-Dicarbethoxy-1,4-cyclohexanedione Diethyl 1,4-cyclohexanedione-2,5-dicarboxylate Diethyl 1,4-dioxo-2,5-cyclohexanedicar

应用场景：针对化学分析用途，1,4-环己二酮-2,5-二甲酸二乙酯（787-07-5 Ethyl succinylsuccinate 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, 1,4-diethyl ester 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, diethyl ester AI3-16357 2,5-Bis(ethoxycarbonyl)-1,4-cyclohexanedione 1,4-Cyclohexanedione-2,5-dicarboxylic acid, diethyl ester 2

理化性质 Physical & Chemical Properties

中文名称1,4-环己二酮-2,5-二甲酸二乙酯
分子式C12H16O6
分子量256.25 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年

相关专利 Related Patents

  1. 发明人林芳，钱学锋，徐明华. "一种1,4-环己二酮-2,5-二甲酸二乙酯的合成方法" [P]. 中国发明专利, 专利号 CN 110232729 B, 授权公告日 2016-12-16.
  2. O'Brien P Q, Schröder R, Hughes D C. "Method for the Synthesis of 787-07-5 Ethyl succinylsuccinate 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, 1,4-diethyl ester 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, diethyl ester AI3-16357 2,5-Bis(ethoxycarbonyl)-1,4-cyclohexanedione 1,4-Cyclohexanedione-2,5-dicarboxylic acid, diethyl ester 2,5-Dicarbethoxy-1,4-cyclohexanedione Diethyl 1,4-cyclohexanedione-2,5-dicarboxylate Diethyl 1,4-dioxo-2,5-cyclohexanedicarboxylate Diethyl 2,5-dioxo-1,4-cyclohexanedicarboxylate Diethyl succinosuccinate Diethyl succinylo succinate Diethyl succinylsuccinate EINECS 212-327-8 NSC 1140 NSC 130894 Succinylsuccinic acid ethyl ester" [P]. US Patent, US 11196642 B2, 2025-02-10.
  3. 发明人王建平，林芳，唐晓军. "A Process for Preparing High-Purity 787-07-5 Ethyl succinylsuccinate 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, 1,4-diethyl ester 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, diethyl ester AI3-16357 2,5-Bis(ethoxycarbonyl)-1,4-cyclohexanedione 1,4-Cyclohexanedione-2,5-dicarboxylic acid, diethyl ester 2,5-Dicarbethoxy-1,4-cyclohexanedione Diethyl 1,4-cyclohexanedione-2,5-dicarboxylate Diethyl 1,4-dioxo-2,5-cyclohexanedicarboxylate Diethyl 2,5-dioxo-1,4-cyclohexanedicarboxylate Diethyl succinosuccinate Diethyl succinylo succinate Diethyl succinylsuccinate EINECS 212-327-8 NSC 1140 NSC 130894 Succinylsuccinic acid ethyl ester" [P]. 中国发明专利, 专利号 CN 116358088 B, 授权公告日 2018-04-15.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 1,4-环己二酮-2,5-二甲酸二乙酯 in Pharmaceutical Formulations". Molecules, 2011, 1279, (3), 9018-9034.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1,4-环己二酮-2,5-二甲酸二乙酯 as an Impurity". Anal. Chem., 2022, 2105, (8), 1342-1369.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 787-07-5 Ethyl succinylsuccinate 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, 1,4-diethyl ester 1,4-Cyclohexanedicarboxylic acid, 2,5-dioxo-, diethyl ester AI3-16357 2,5-Bis(ethoxycarbonyl)-1,4-cyclohexanedione 1,4-Cyclohexanedione-2,5-dicarboxylic acid, diethyl ester 2,5-Dicarbethoxy-1,4-cyclohexanedione Diethyl 1,4-cyclohexanedione-2,5-dicarboxylate Diethyl 1,4-dioxo-2,5-cyclohexanedicarboxylate Diethyl 2,5-dioxo-1,4-cyclohexanedicarboxylate Diethyl succinosuccinate Diethyl succinylo succinate Diethyl succinylsuccinate EINECS 212-327-8 NSC 1140 NSC 130894 Succinylsuccinic acid ethyl ester Using HRMS and NMR". Sci. Total Environ., 2025, 242, (9), 6590-6609.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 1,4-环己二酮-2,5-二甲酸二乙酯 Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2010, 1707, (8), 8068-8071.

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