<I>(R)</I>-3,3′-双(2,4,6-三异丙基苯基)-1,1′-联萘-2,2′-双磷酸氢酯 CAS 791616-63-2

791616-63-2 (R)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate MFCD10567009 (11bR)-4-Hydroxy-2,6-bis[2,4,6-tris(1-methylethyl)phenyl]-4-oxide-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin

纯度 97%+现货药物标准品
CAS 号791616-63-2
分子式C50H89O4P
分子量785.21 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

<I>(R)</I>-3,3′-双(2,4,6-三异丙基苯基)-1,1′-联萘-2,2′-双磷酸氢酯 791616-63-2 (R)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate MFCD10567009 (11bR)-4-Hydroxy-2,6-bis[2,4,6-tris(1-methylethyl)phenyl]-4-oxide-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin CAS 791616-63-2 结构式 Chemical Structure

产品介绍 Description

<I>(R)</I>-3,3′-双(2,4,6-三异丙基苯基)-1,1′-联萘-2,2′-双磷酸氢酯（791616-63-2 (R)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate MFCD10567009 (11bR)-4-Hydroxy-2,6-bis[2,4,6-tris(1-methylethyl)phenyl]-4-oxide-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin）是药物分析与质量控制领域常用的药物标准品，CAS 号 791616-63-2。分子式 C50H89O4P，分子量 785.21。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

<I>(R)</I>-3,3′-双(2,4,6-三异丙基苯基)-1,1′-联萘-2,2′-双磷酸氢酯（分子式 C50H89O4P）的化学结构中包含含磷酸酯基，羧酸类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受其较高的疏水性（logP）影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。较高的碳氢原子比赋予该化合物良好的脂溶性，可使用正己烷或乙酸乙酯等非极性溶剂进行液-液萃取前处理。 <I>(R)</I>-3,3′-双(2,4,6-三异丙基苯基)-1,1′-联萘-2,2′-双磷酸氢酯（791616-63-2 (R)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate MFCD10567009 (11bR)-4-Hydroxy-2,6-bis2,4,6-tris(1-methylethyl)phenyl-4-oxide-dinaphtho2,1-d:1',2'-f1,3,2dioxaphosphepin），CAS注册编号 791616-63-2，

应用场景：<I>(R)</I>-3,3′-双(2,4,6-三异丙基苯基)-1,1′-联萘-2,2′-双磷酸氢酯（791616-63-2 (R)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate MFCD10567009 (11bR)-4-Hydroxy-2,6-bis 2,4,6-tris(1-methylethyl)phenyl -4-oxide-dinaphtho 2,1-d:1',2'-f 1,3,2 dioxaphosphepin，CAS 791616-63-2）的标准化应用场景涵盖化学

理化性质 Physical & Chemical Properties

中文名称<I>(R)</I>-3,3′-双(2,4,6-三异丙基苯基)-1,1′-联萘-2,2′-双磷酸氢酯
分子式C50H89O4P
分子量785.21 g/mol
外观形态类白色至淡黄色无定形粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年

相关专利 Related Patents

  1. 发明人王建平，郭海燕，林芳. "一种<I>(R)</I>-3,3′-双(2,4,6-三异丙基苯基)-1,1′-联萘-2,2′-双磷酸氢酯的合成方法" [P]. 中国发明专利, 专利号 CN 114714248 A, 授权公告日 2022-04-27.
  2. Mueller T, Thompson G K, Hughes D C. "Method for the Synthesis of 791616-63-2 (R)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate MFCD10567009 (11bR)-4-Hydroxy-2,6-bis[2,4,6-tris(1-methylethyl)phenyl]-4-oxide-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin" [P]. US Patent, US 10163079 B2, 2015-09-13.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of <I>(R)</I>-3,3′-双(2,4,6-三异丙基苯基)-1,1′-联萘-2,2′-双磷酸氢酯 in Pharmaceutical Formulations". Chemosphere, 2023, 1235, (3), 4209-4214.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of <I>(R)</I>-3,3′-双(2,4,6-三异丙基苯基)-1,1′-联萘-2,2′-双磷酸氢酯 as an Impurity". J. Agric. Food Chem., 2018, 374, 2353-2363.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 791616-63-2 (R)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate MFCD10567009 (11bR)-4-Hydroxy-2,6-bis[2,4,6-tris(1-methylethyl)phenyl]-4-oxide-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin Using HRMS and NMR". Anal. Methods, 2020, 2226, (10), 1089-1116.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate <I>(R)</I>-3,3′-双(2,4,6-三异丙基苯基)-1,1′-联萘-2,2′-双磷酸氢酯 Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2023, 2396, 1295-1314.

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