2-氯乙基对甲苯磺酸酯 CAS 80-41-1
80-41-1 2-Chloroethyl toluene-4-sulphonate Ethanol, 2-chloro-, 4-methylbenzenesulfonate Ethanol, 2-chloro-, p-toluenesulfonate (8CI) p-Toluenesulfonic acid, beta-chloroethyl ester Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate) 4-11-00-00249 (Beilstein Handbook Reference) AI3-02279 BRN 1968816 2-Chlorethylester kyseliny p-toluensulfonove [Czech] 2-Chloroethanol 4-methylbenzenesulfonate 2-Chloroethanol p-toluenesulfonate beta-Chloroethyl p-toluenesulfonate 2-Chloroethyl p-toluenesulfonate 2-Chloroethyl tosylate 2-Chloroethyl p-tosylate beta-Chloroethylester kyseliny p-toluensulfonove [Czech] EINECS 201-277-2 NSC 6079 p-Toluenesulfonic acid, 2-chloroethyl ester p-Toluenesulfonic acid-2-chloroethyl ester 2-(p-Toluenesulfonyloxy)ethyl chloride 2-Tosyloxyethyl chloride 2-Chlorethylester kyseliny p-toluensulfonove beta-Chloroethylester kyseliny p-toluensulfonove
| CAS 号 | 80-41-1 |
| 分子式 | C9H17ClO3S |
| 分子量 | 240.75 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
2-氯乙基对甲苯磺酸酯（英文名 80-41-1 2-Chloroethyl toluene-4-sulphonate Ethanol, 2-chloro-, 4-methylbenzenesulfonate Ethanol, 2-chloro-, p-toluenesulfonate (8CI) p-Toluenesulfonic acid, beta-chloroethyl ester Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate) 4-11-00-00249 (Beilstein Handbook Reference) AI3-02279 BRN 1968816 2-Chlorethylester kyseliny p-toluensulfonove [Czech] 2-Chloroethanol 4-methylbenzenesulfonate 2-Chloroethanol p-toluenesulfonate beta-Chloroethyl p-toluenesulfonate 2-Chloroethyl p-toluenesulfonate 2-Chloroethyl tosylate 2-Chloroethyl p-tosylate beta-Chloroethylester kyseliny p-toluensulfonove [Czech] EINECS 201-277-2 NSC 6079 p-Toluenesulfonic acid, 2-chloroethyl ester p-Toluenesulfonic acid-2-chloroethyl ester 2-(p-Toluenesulfonyloxy)ethyl chloride 2-Tosyloxyethyl chloride 2-Chlorethylester kyseliny p-toluensulfonove beta-Chloroethylester kyseliny p-toluensulfonove，CAS 80-41-1）属于药物标准品。分子式 C9H17ClO3S，分子量 240.75。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括2-氯乙基对甲苯磺酸酯在内的目标物的控制。 2-氯乙基对甲苯磺酸酯（80-41-1 2-Chloroethyl toluene-4-sulphonate Ethanol, 2-chloro-, 4-methylbenzenesulfonate Ethanol, 2-chloro-, p-toluenesulfonate (8CI) p-Toluenesulfonic acid, beta-chloroethyl ester Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate) 4-11-00-00249 (Beilstein Handbook Reference) AI3-02279 BRN 1968816 2-Chlorethylester kyseliny p-toluensulfonove Czech 2-Chloroethanol 4-methylbenzenesulfonate 2-Chloroethanol p-toluenesulfonate beta-Chlor
应用场景：从实际应用出发，2-氯乙基对甲苯磺酸酯（CAS 80-41-1）在化学分析中作为关键的基准对照物质。 推荐以2-氯乙基对甲苯磺酸酯配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于阴凉处（≤25°C）保存，密封防潮，密闭保存防止挥发条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。
理化性质 Physical & Chemical Properties
| 中文名称 | 2-氯乙基对甲苯磺酸酯 |
| 分子式 | C9H17ClO3S |
| 分子量 | 240.75 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，密封防潮，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 1.0 |
| CAS登记年份（估） | 1957年 |
| 卤素含量 | Cl取代 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- 发明人孙丽萍，韩伟，周伟. "一种2-氯乙基对甲苯磺酸酯的合成方法" [P]. 中国发明专利, 专利号 CN 112919576 A, 授权公告日 2023-11-13.
- 发明人杨光，郭海燕，高志强. "Method for the Synthesis of 80-41-1 2-Chloroethyl toluene-4-sulphonate Ethanol, 2-chloro-, 4-methylbenzenesulfonate Ethanol, 2-chloro-, p-toluenesulfonate (8CI) p-Toluenesulfonic acid, beta-chloroethyl ester Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate) 4-11-00-00249 (Beilstein Handbook Reference) AI3-02279 BRN 1968816 2-Chlorethylester kyseliny p-toluensulfonove [Czech] 2-Chloroethanol 4-methylbenzenesulfonate 2-Chloroethanol p-toluenesulfonate beta-Chloroethyl p-toluenesulfonate 2-Chloroethyl p-toluenesulfonate 2-Chloroethyl tosylate 2-Chloroethyl p-tosylate beta-Chloroethylester kyseliny p-toluensulfonove [Czech] EINECS 201-277-2 NSC 6079 p-Toluenesulfonic acid, 2-chloroethyl ester p-Toluenesulfonic acid-2-chloroethyl ester 2-(p-Toluenesulfonyloxy)ethyl chloride 2-Tosyloxyethyl chloride 2-Chlorethylester kyseliny p-toluensulfonove beta-Chloroethylester kyseliny p-toluensulfonove" [P]. 中国发明专利, 专利号 CN 110328403 B, 授权公告日 2022-06-08.
- Martínez F, Björnsson E, Jørgensen K. "A Process for Preparing High-Purity 80-41-1 2-Chloroethyl toluene-4-sulphonate Ethanol, 2-chloro-, 4-methylbenzenesulfonate Ethanol, 2-chloro-, p-toluenesulfonate (8CI) p-Toluenesulfonic acid, beta-chloroethyl ester Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate) 4-11-00-00249 (Beilstein Handbook Reference) AI3-02279 BRN 1968816 2-Chlorethylester kyseliny p-toluensulfonove [Czech] 2-Chloroethanol 4-methylbenzenesulfonate 2-Chloroethanol p-toluenesulfonate beta-Chloroethyl p-toluenesulfonate 2-Chloroethyl p-toluenesulfonate 2-Chloroethyl tosylate 2-Chloroethyl p-tosylate beta-Chloroethylester kyseliny p-toluensulfonove [Czech] EINECS 201-277-2 NSC 6079 p-Toluenesulfonic acid, 2-chloroethyl ester p-Toluenesulfonic acid-2-chloroethyl ester 2-(p-Toluenesulfonyloxy)ethyl chloride 2-Tosyloxyethyl chloride 2-Chlorethylester kyseliny p-toluensulfonove beta-Chloroethylester kyseliny p-toluensulfonove" [P]. European Patent, EP 3544633 A1, 2024-11-06.
参考文献 Literature
- Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 2-氯乙基对甲苯磺酸酯 in Pharmaceutical Formulations". Biomed. Chromatogr., 2012, 2280, (7), 696-716.
- Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-氯乙基对甲苯磺酸酯 as an Impurity". J. Pharm. Biomed. Anal., 2018, 1076, (9), 2326-2333.
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