1,8-二氨基-<I>p</I>-薄荷烷，<I>顺式</I>和<I>反式</I> 异构体混合物 CAS 80-52-4

80-52-4 S583DR301G 1,8-Diamino-p-menthane Cyclohexanemethanamine, 4-amino-alpha,alpha,4-trimethyl- p-Menthane-1,8-diamine 1,8-Menthanediamine p-Menthane-1,8-diyldiamine 4-13-00-00023 (Beilstein Handbook Reference) AI3-23799 BRN 1098767 CCRIS 4836 EINECS 201-287-7 Menthane diamine Menthanediamine NSC 5612 USAF RH-4 UNII-S583DR301G

纯度 97%+现货药物标准品
CAS 号80-52-4
分子式C10H22N2
分子量170.30 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1,8-二氨基-<I>p</I>-薄荷烷，<I>顺式</I>和<I>反式</I> 异构体混合物 80-52-4 S583DR301G 1,8-Diamino-p-menthane Cyclohexanemethanamine, 4-amino-alpha,alpha,4-trimethyl- p-Menthane-1,8-diamine 1,8-Menthanediamine p-Menthane-1,8-diyldiamine 4-13-00-00023 (Beilstein Handbook Reference) AI3-23799 BRN 1098767 CCRIS 4836 EINECS 201-287-7 Menthane diamine Menthanediamine NSC 5612 USAF RH-4 UNII-S583DR301G CAS 80-52-4 结构式 Chemical Structure

产品介绍 Description

1,8-二氨基-<I>p</I>-薄荷烷，<I>顺式</I>和<I>反式</I> 异构体混合物（英文名 80-52-4 S583DR301G 1,8-Diamino-p-menthane Cyclohexanemethanamine, 4-amino-alpha,alpha,4-trimethyl- p-Menthane-1,8-diamine 1,8-Menthanediamine p-Menthane-1,8-diyldiamine 4-13-00-00023 (Beilstein Handbook Reference) AI3-23799 BRN 1098767 CCRIS 4836 EINECS 201-287-7 Menthane diamine Menthanediamine NSC 5612 USAF RH-4 UNII-S583DR301G，CAS 80-52-4）属于药物标准品。分子式 C10H22N2，分子量 170.30。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括1,8-二氨基-<I>p</I>-薄荷烷，<I>顺式</I>和<I>反式</I> 异构体混合物在内的目标物的控制。 1,8-二氨基-<I>p</I>-薄荷烷，<I>顺式</I>和<I>反式</I> 异构体混合物（80-52-4 S583DR301G 1,8-Diamino-p-menthane Cyclohexanemethanamine, 4-amino-alpha,alpha,4-trimethyl- p-Menthane-1,8-diamine 1,8-Menthanediamine p-Menthane-1,8-diyldiamine 4-13-00-00023 (Beilstein Handbook Reference) AI3-23799 BRN 1098767 CCRIS 4836 EINECS 201-287-7 Menthane diamine Menthanediamine NSC 5612 USAF RH-4 UNII-S583DR301G），CAS注册编号 80-52-4，化学分子式为 C10H22N

应用场景：1,8-二氨基-<I>p</I>-薄荷烷，<I>顺式</I>和<I>反式</I> 异构体混合物（80-52-4 S583DR301G 1,8-Diamino-p-menthane Cyclohexanemethanamine, 4-amino-alpha,alpha,4-trimethyl- p-Menthane-1,8-diamine 1,8-Menthanediamine p-Menthane-1,8-diyldiamine 4-13-00-00023 (Beilstein Handbook Reference) AI3-23799 BRN 1098767 CCRIS 4836 EINEC

理化性质 Physical & Chemical Properties

中文名称1,8-二氨基-<I>p</I>-薄荷烷，<I>顺式</I>和<I>反式</I> 异构体混合物
分子式C10H22N2
分子量170.30 g/mol
外观形态白色至类白色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1957年
含氮原子数2

相关专利 Related Patents

  1. Hughes D C, Stevens L M, Anderson J P. "一种1,8-二氨基-<I>p</I>-薄荷烷，<I>顺式</I>和<I>反式</I> 异构体混合物的合成方法" [P]. US Patent, US 11904358 B2, 2018-08-24.
  2. 发明人沈红梅，罗永刚，孙丽萍. "Method for the Synthesis of 80-52-4 S583DR301G 1,8-Diamino-p-menthane Cyclohexanemethanamine, 4-amino-alpha,alpha,4-trimethyl- p-Menthane-1,8-diamine 1,8-Menthanediamine p-Menthane-1,8-diyldiamine 4-13-00-00023 (Beilstein Handbook Reference) AI3-23799 BRN 1098767 CCRIS 4836 EINECS 201-287-7 Menthane diamine Menthanediamine NSC 5612 USAF RH-4 UNII-S583DR301G" [P]. 中国发明专利, 专利号 CN 115178457 A, 授权公告日 2025-11-15.
  3. Chen K W, Johnson M A, Anderson J P. "A Process for Preparing High-Purity 80-52-4 S583DR301G 1,8-Diamino-p-menthane Cyclohexanemethanamine, 4-amino-alpha,alpha,4-trimethyl- p-Menthane-1,8-diamine 1,8-Menthanediamine p-Menthane-1,8-diyldiamine 4-13-00-00023 (Beilstein Handbook Reference) AI3-23799 BRN 1098767 CCRIS 4836 EINECS 201-287-7 Menthane diamine Menthanediamine NSC 5612 USAF RH-4 UNII-S583DR301G" [P]. US Patent, US 11818729 B2, 2016-07-02.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 1,8-二氨基-<I>p</I>-薄荷烷，<I>顺式</I>和<I>反式</I> 异构体混合物 in Pharmaceutical Formulations". Chromatographia, 2012, 2089, 6893-6907.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1,8-二氨基-<I>p</I>-薄荷烷，<I>顺式</I>和<I>反式</I> 异构体混合物 as an Impurity". J. Agric. Food Chem., 2022, 1766, 6981-7010.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 80-52-4 S583DR301G 1,8-Diamino-p-menthane Cyclohexanemethanamine, 4-amino-alpha,alpha,4-trimethyl- p-Menthane-1,8-diamine 1,8-Menthanediamine p-Menthane-1,8-diyldiamine 4-13-00-00023 (Beilstein Handbook Reference) AI3-23799 BRN 1098767 CCRIS 4836 EINECS 201-287-7 Menthane diamine Menthanediamine NSC 5612 USAF RH-4 UNII-S583DR301G Using HRMS and NMR". Anal. Chem., 2025, 1130, (8), 6766-6774.

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