1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid CAS 80097-15-0

1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号80097-15-0
分子式C14H10F3NO3
分子量297.23 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid 1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid CAS 80097-15-0 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid（1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid）为药物标准品，CAS 登记号 80097-15-0，分子式 C14H10F3NO3，分子量 297.23。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括1-methyl-4-oxo-5-3-(trifluoromethyl)phenyl-1,4-dihydropyridine-3-carboxylic acid在内的目标物的控制。 CAS编号 80097-15-0 对应的化合物1-methyl-4-oxo-5-3-(trifluoromethyl)phenyl-1,4-dihydropyridine-3-carboxylic acid（英文标识 1-methyl-4-oxo-5-3-(trifluoromethyl)phenyl-1,4-dihydropyridine-3-carboxylic acid），化学式 C14H10F3NO3，相对分子质量 297.23。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代的影响，1-methyl-4-oxo-5-3-(trifluoromethyl)phenyl-1,4-dihydropyridine-3-carboxylic acid表现为淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）

应用场景：针对化学分析用途，1-methyl-4-oxo-5- 3-(trifluoromethyl)phenyl -1,4-dihydropyridine-3-carboxylic acid（1-methyl-4-oxo-5- 3-(trifluoromethyl)phenyl -1,4-dihydropyridine-3-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以1-methyl-4-oxo-5- 3-(trifluoromethyl)phenyl -1,4-dihydropyridine-3-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现

理化性质 Physical & Chemical Properties

中文名称1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid
分子式C14H10F3NO3
分子量297.23 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1979年
卤素含量F取代
含氮原子数1

相关专利 Related Patents

  1. Schröder R, Rossi M, Nowak P. "一种1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid的合成方法" [P]. European Patent, EP 3121172 A1, 2023-11-21.
  2. 发明人周伟，何建平，钱学锋. "Method for the Synthesis of 1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 111553741 B, 授权公告日 2022-01-07.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid in Pharmaceutical Formulations". Biomed. Chromatogr., 2020, 384, (3), 4152-4165.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid as an Impurity". J. Chromatogr. A, 2015, 2462, 4894-4920.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid Using HRMS and NMR". Anal. Chem., 2013, 692, 4862-4866.
  4. Kim S H, Park J Y. "Forced Degradation Studies to Evaluate 1-methyl-4-oxo-5-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2015, 1275, (7), 1747-1772.

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