2-[4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy]acetohydrazide CAS 828299-12-3

2-[4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy]acetohydrazide

纯度 97%+现货药物标准品
CAS 号828299-12-3
分子式C16H20N4O4S
分子量364.42 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-[4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy]acetohydrazide 2-[4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy]acetohydrazide CAS 828299-12-3 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的2-[4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy]acetohydrazide（2-[4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy]acetohydrazide）为药物标准品，CAS 登记号 828299-12-3，分子式 C16H20N4O4S，分子量 364.42。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

2-4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxyacetohydrazide（2-4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxyacetohydrazide），CAS注册编号 828299-12-3，化学分子式为 C16H20N4O4S，分子量 364.42 g/mol。 2-4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxyacetohydrazide（C16H20N4O4S）含有黄酮骨架，酰胺类，含砜基，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析

应用场景：针对化学分析用途，2- 4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy acetohydrazide（2- 4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy acetohydrazide）是具有明确定量溯源的认证级对照品。 推荐以2- 4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-me

理化性质 Physical & Chemical Properties

中文名称2-[4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy]acetohydrazide
分子式C16H20N4O4S
分子量364.42 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年
含氮原子数4
含硫原子数1

相关专利 Related Patents

  1. 发明人何建平，林芳，徐明华. "一种2-[4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy]acetohydrazide的合成方法" [P]. 中国发明专利, 专利号 CN 116214714 B, 授权公告日 2023-01-06.
  2. Davis P L, Klinger H, Roberts E F. "Method for the Synthesis of 2-[4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy]acetohydrazide" [P]. US Patent, US 10865773 B2, 2019-02-12.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of 2-[4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy]acetohydrazide in Pharmaceutical Formulations". Biomed. Chromatogr., 2018, 1598, 3532-3543.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-[4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy]acetohydrazide as an Impurity". Rapid Commun. Mass Spectrom., 2015, 1050, 9627-9653.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 2-[4-(5-acetyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2-methoxyphenoxy]acetohydrazide Using HRMS and NMR". Anal. Chem., 2024, 1105, (1), 5489-5493.

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