ethyl 6-(chloromethyl)-4-[4-methoxy-3-(methoxymethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate CAS 832740-12-2

ethyl 6-(chloromethyl)-4-[4-methoxy-3-(methoxymethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

纯度 97%+现货药物标准品
CAS 号832740-12-2
分子式C17H21ClN2O5
分子量368.81 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

ethyl 6-(chloromethyl)-4-[4-methoxy-3-(methoxymethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate ethyl 6-(chloromethyl)-4-[4-methoxy-3-(methoxymethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate CAS 832740-12-2 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品ethyl 6-(chloromethyl)-4-[4-methoxy-3-(methoxymethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate（ethyl 6-(chloromethyl)-4-[4-methoxy-3-(methoxymethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate，CAS 832740-12-2），分子式 C17H21ClN2O5，分子量 368.81。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

化学式为 C17H21ClN2O5 的ethyl 6-(chloromethyl)-4-4-methoxy-3-(methoxymethyl)phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate（ethyl 6-(chloromethyl)-4-4-methoxy-3-(methoxymethyl)phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate），其CAS登记号是 832740-12-2，分子量为 368.81 g/mol。 ethyl 6-(chloromethyl)-4-4-methoxy-3-(methoxymethyl)phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate（C17H21ClN2O5）含有黄酮骨架，酰胺类，含羟基，含醚键，含氯取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。含氮

应用场景：在化学分析实验室中，ethyl 6-(chloromethyl)-4- 4-methoxy-3-(methoxymethyl)phenyl -2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate（CAS 832740-12-2）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以ethyl 6-(chloromethyl)-4- 4-methoxy-3-(methoxymethyl)phenyl -2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate配制标准系列工作溶液，用于建立标准曲线实现

理化性质 Physical & Chemical Properties

中文名称ethyl 6-(chloromethyl)-4-[4-methoxy-3-(methoxymethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
分子式C17H21ClN2O5
分子量368.81 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. Williams B T, Yamamoto T, Park J H. "一种ethyl 6-(chloromethyl)-4-[4-methoxy-3-(methoxymethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate的合成方法" [P]. US Patent, US 9411419 B2, 2016-12-08.
  2. Martínez F, Johansson L, Jørgensen K. "Method for the Synthesis of ethyl 6-(chloromethyl)-4-[4-methoxy-3-(methoxymethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate" [P]. European Patent, EP 3698173 A1, 2023-04-23.
  3. 发明人韩伟，赵玉洁，杨光. "A Process for Preparing High-Purity ethyl 6-(chloromethyl)-4-[4-methoxy-3-(methoxymethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate" [P]. 中国发明专利, 专利号 CN 113761527 A, 授权公告日 2016-03-04.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of ethyl 6-(chloromethyl)-4-[4-methoxy-3-(methoxymethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate in Pharmaceutical Formulations". J. Nat. Prod., 2024, 593, (1), 7588-7615.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of ethyl 6-(chloromethyl)-4-[4-methoxy-3-(methoxymethyl)phenyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate as an Impurity". Anal. Chem., 2012, 1365, (4), 4708-4734.

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