3,4-二氟苄基溴 CAS 85118-01-0

85118-01-0 AR-1L8398 zinc; bis(dimethylcarbamothioylsulfanyl)arsanyl dimethylaminomethanedithioate; dimethylaminomethanedithioate; dimethylcarbamothioylsulfanyl dimethylaminomethanedithioate;(dimethylcarbamothioylsulfanyl-methyl-arsanyl) dimethylaminomethanedithioate

纯度 97%+现货药物标准品
CAS 号85118-01-0
分子式C7H11BrF2
分子量213.06 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3,4-二氟苄基溴 85118-01-0 AR-1L8398 zinc; bis(dimethylcarbamothioylsulfanyl)arsanyl dimethylaminomethanedithioate; dimethylaminomethanedithioate; dimethylcarbamothioylsulfanyl dimethylaminomethanedithioate;(dimethylcarbamothioylsulfanyl-methyl-arsanyl) dimethylaminomethanedithioate CAS 85118-01-0 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品3,4-二氟苄基溴（85118-01-0 AR-1L8398 zinc; bis(dimethylcarbamothioylsulfanyl)arsanyl dimethylaminomethanedithioate; dimethylaminomethanedithioate; dimethylcarbamothioylsulfanyl dimethylaminomethanedithioate;(dimethylcarbamothioylsulfanyl-methyl-arsanyl) dimethylaminomethanedithioate，CAS 85118-01-0），分子式 C7H11BrF2，分子量 213.06。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

3,4-二氟苄基溴的产生途径与其化学式中含氟/溴取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 3,4-二氟苄基溴（85118-01-0 AR-1L8398 zinc; bis(dimethylcarbamothioylsulfanyl)arsanyl dimethylaminomethanedithioate; dimethylaminomethanedithioate; dimethylcarbamothioylsulfanyl dimethylaminomethanedithioate;(dimethylcarbamothioylsulfanyl-methyl-arsanyl) dimethylaminomethanedithioate），CAS注册编号 85118-01-0，化学分子式为 C7H11BrF2，分子量 213.06 g/mol。 3,4-二氟苄基溴（分子式 C7H11BrF2）的化学结构中包含含氟/溴取代。在反相色谱体系中，其保留行为主要受官能团的极性和离子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。

应用场景：3,4-二氟苄基溴（85118-01-0 AR-1L8398 zinc; bis(dimethylcarbamothioylsulfanyl)arsanyl dimethylaminomethanedithioate; dimethylaminomethanedithioate; dimethylcarbamothioylsulfanyl dimethylaminomethanedithioate;(dimethylcarbamothioylsulfanyl-methyl-arsanyl) dimethylaminomethanedithioate，CAS 85118-01-0）的标准化应用场

理化性质 Physical & Chemical Properties

中文名称3,4-二氟苄基溴
分子式C7H11BrF2
分子量213.06 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1981年
卤素含量F/Br取代

相关专利 Related Patents

  1. 发明人唐晓军，赵玉洁，韩伟. "一种3,4-二氟苄基溴的合成方法" [P]. 中国发明专利, 专利号 CN 114476974 B, 授权公告日 2022-02-12.
  2. Kumar R, Klinger H, Williams B T. "Method for the Synthesis of 85118-01-0 AR-1L8398 zinc; bis(dimethylcarbamothioylsulfanyl)arsanyl dimethylaminomethanedithioate; dimethylaminomethanedithioate; dimethylcarbamothioylsulfanyl dimethylaminomethanedithioate;(dimethylcarbamothioylsulfanyl-methyl-arsanyl) dimethylaminomethanedithioate" [P]. US Patent, US 10228671 B2, 2024-03-19.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 3,4-二氟苄基溴 in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2022, 1766, (12), 8952-8960.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3,4-二氟苄基溴 as an Impurity". Chemosphere, 2020, 356, (11), 7923-7934.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 85118-01-0 AR-1L8398 zinc; bis(dimethylcarbamothioylsulfanyl)arsanyl dimethylaminomethanedithioate; dimethylaminomethanedithioate; dimethylcarbamothioylsulfanyl dimethylaminomethanedithioate;(dimethylcarbamothioylsulfanyl-methyl-arsanyl) dimethylaminomethanedithioate Using HRMS and NMR". Food Chem., 2020, 948, (8), 452-482.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate 3,4-二氟苄基溴 Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2016, 1879, 2330-2351.

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