1,2-双（2-氨基苯氧基）乙烷-<I> N, N, N′, N′</I>-四乙酸 CAS 85233-19-8

85233-19-8 K22DDW77C0 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene)bis(N-(carboxymethyl)- Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene))bis(N-(carboxymethyl)-,tetrapotassium salt Bapeta BAPTA 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Ca(II)-bapta UNII-K22DDW77C0

纯度 97%+现货药物标准品
CAS 号85233-19-8
分子式C22H36N2O10
分子量488.53 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1,2-双（2-氨基苯氧基）乙烷-<I> N, N, N′, N′</I>-四乙酸 85233-19-8 K22DDW77C0 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene)bis(N-(carboxymethyl)- Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene))bis(N-(carboxymethyl)-,tetrapotassium salt Bapeta BAPTA 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Ca(II)-bapta UNII-K22DDW77C0 CAS 85233-19-8 结构式 Chemical Structure

产品介绍 Description

1,2-双（2-氨基苯氧基）乙烷-<I> N, N, N′, N′</I>-四乙酸（85233-19-8 K22DDW77C0 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene)bis(N-(carboxymethyl)- Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene))bis(N-(carboxymethyl)-,tetrapotassium salt Bapeta BAPTA 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Ca(II)-bapta UNII-K22DDW77C0，CAS 号 85233-19-8）是 CATO 佳途自主生产的药物标准品，分子式 C22H36N2O10，分子量 488.53。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，1,2-双（2-氨基苯氧基）乙烷-<I> N, N, N′, N′</I>-四乙酸的分子量为488.53 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C22H36N2O10 的1,2-双（2-氨基苯氧基）乙烷-<I> N, N, N′, N′</I>-四乙酸（85233-19-8 K22DDW77C0 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene)bis(N-(carboxymethyl)- Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene))bis(N-(carboxymethyl)-,tetrapotassium salt Bapeta BAPTA 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Ca(II)-bapta UNII-K22D

应用场景：1,2-双（2-氨基苯氧基）乙烷-<I> N, N, N′, N′</I>-四乙酸（85233-19-8 K22DDW77C0 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene)bis(N-(carboxymethyl)- Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene))bis(N-(carboxymethyl)-,tetrapotassium salt Bapeta BAP

理化性质 Physical & Chemical Properties

中文名称1,2-双（2-氨基苯氧基）乙烷-<I> N, N, N′, N′</I>-四乙酸
分子式C22H36N2O10
分子量488.53 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1981年
含氮原子数2

相关专利 Related Patents

  1. 发明人黄志刚，王建平，朱建伟. "一种1,2-双（2-氨基苯氧基）乙烷-<I> N, N, N′, N′</I>-四乙酸的合成方法" [P]. 中国发明专利, 专利号 CN 114735758 A, 授权公告日 2022-06-26.
  2. 发明人高志强，周伟，沈红梅. "Method for the Synthesis of 85233-19-8 K22DDW77C0 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene)bis(N-(carboxymethyl)- Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene))bis(N-(carboxymethyl)-,tetrapotassium salt Bapeta BAPTA 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Ca(II)-bapta UNII-K22DDW77C0" [P]. 中国发明专利, 专利号 CN 110459662 A, 授权公告日 2015-11-16.
  3. Park J H, Klinger H, Williams B T. "A Process for Preparing High-Purity 85233-19-8 K22DDW77C0 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene)bis(N-(carboxymethyl)- Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene))bis(N-(carboxymethyl)-,tetrapotassium salt Bapeta BAPTA 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Ca(II)-bapta UNII-K22DDW77C0" [P]. US Patent, US 9352077 B2, 2024-10-11.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 1,2-双（2-氨基苯氧基）乙烷-<I> N, N, N′, N′</I>-四乙酸 in Pharmaceutical Formulations". Chemosphere, 2021, 1493, (1), 8679-8695.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1,2-双（2-氨基苯氧基）乙烷-<I> N, N, N′, N′</I>-四乙酸 as an Impurity". J. Sep. Sci., 2012, 2394, 1568-1590.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of 85233-19-8 K22DDW77C0 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene)bis(N-(carboxymethyl)- Glycine, N,N'-(1,2-ethanediylbis(oxy-2,1-phenylene))bis(N-(carboxymethyl)-,tetrapotassium salt Bapeta BAPTA 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Ca(II)-bapta UNII-K22DDW77C0 Using HRMS and NMR". Environ. Sci. Technol., 2011, 594, 9328-9333.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate 1,2-双（2-氨基苯氧基）乙烷-<I> N, N, N′, N′</I>-四乙酸 Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2014, 1498, (5), 9168-9180.

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