N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide CAS 86303-23-3

(3a,5b,12a)-N,N-Bis[3-(D-gluconoylamino)propyl]-3,12-dihydroxycholan-24-amide 86303-23-3 Deoxy-BigCHAP N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide big chap, deoxy deoxy-bigchap(n,n-bis[3-glucoriamidopropyl]-deoxycholamide deoxybigchap=bigchap,deoxy n,n'-bis(3-d-gluconamidopropyl)-deoxy-cholamide n,n-bis(3-gluconamidopropyl)deoxycholamide n,n-bis-(3-d-gluconamidopropyl)deoxycholamide

纯度 97%+现货药物标准品
CAS 号86303-23-3
分子式C42H75N3O15
分子量862.06 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide (3a,5b,12a)-N,N-Bis[3-(D-gluconoylamino)propyl]-3,12-dihydroxycholan-24-amide 86303-23-3 Deoxy-BigCHAP N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide big chap, deoxy deoxy-bigchap(n,n-bis[3-glucoriamidopropyl]-deoxycholamide deoxybigchap=bigchap,deoxy n,n'-bis(3-d-gluconamidopropyl)-deoxy-cholamide n,n-bis(3-gluconamidopropyl)deoxycholamide n,n-bis-(3-d-gluconamidopropyl)deoxycholamide CAS 86303-23-3 结构式 Chemical Structure

产品介绍 Description

N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide（英文名 (3a,5b,12a)-N,N-Bis[3-(D-gluconoylamino)propyl]-3,12-dihydroxycholan-24-amide 86303-23-3 Deoxy-BigCHAP N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide big chap, deoxy deoxy-bigchap(n,n-bis[3-glucoriamidopropyl]-deoxycholamide deoxybigchap=bigchap,deoxy n,n'-bis(3-d-gluconamidopropyl)-deoxy-cholamide n,n-bis(3-gluconamidopropyl)deoxycholamide n,n-bis-(3-d-gluconamidopropyl)deoxycholamide，CAS 86303-23-3）属于药物标准品。分子式 C42H75N3O15，分子量 862.06。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

N,N-Bis3-(D-gluconamido)propyldeoxycholamide（分子式 C42H75N3O15）的化学结构中包含含氮杂环结构，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。由于结构中存在共轭发色团，该化合物在200-400 nm区间具有显著的紫外吸收，便于HPLC-UV检测。 N,N-Bis3-(D-gluconamido)propyldeoxycholamide（(3a,5b,12a)-N,N-Bis3-(D-gluconoylamino)propyl-3,12-dihydroxycholan-24-amide 86303-23-3 Deoxy-BigCHAP N,N-Bis3-(D-gluconamido)propyldeoxycholamide big chap, deoxy deoxy-bigchap(n,n-bis3-glucoriamidopropyl-deoxycholamide deoxybigchap=bigchap,

应用场景：N,N-Bis 3-(D-gluconamido)propyl deoxycholamide（(3a,5b,12a)-N,N-Bis 3-(D-gluconoylamino)propyl -3,12-dihydroxycholan-24-amide 86303-23-3 Deoxy-BigCHAP N,N-Bis 3-(D-gluconamido)propyl deoxycholamide big chap, deoxy deoxy-bigchap(n,n-bis 3-glucoriamidopropyl -deoxycholamide deoxybigchap=bigchap,deoxy n

理化性质 Physical & Chemical Properties

中文名称N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide
分子式C42H75N3O15
分子量862.06 g/mol
外观形态类白色至淡黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1981年
含氮原子数3

相关专利 Related Patents

  1. Williams B T, Stevens L M, Anderson J P. "一种N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide的合成方法" [P]. US Patent, US 9507169 B2, 2021-02-26.
  2. 发明人林芳，沈红梅，李文辉. "Method for the Synthesis of (3a,5b,12a)-N,N-Bis[3-(D-gluconoylamino)propyl]-3,12-dihydroxycholan-24-amide 86303-23-3 Deoxy-BigCHAP N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide big chap, deoxy deoxy-bigchap(n,n-bis[3-glucoriamidopropyl]-deoxycholamide deoxybigchap=bigchap,deoxy n,n'-bis(3-d-gluconamidopropyl)-deoxy-cholamide n,n-bis(3-gluconamidopropyl)deoxycholamide n,n-bis-(3-d-gluconamidopropyl)deoxycholamide" [P]. 中国发明专利, 专利号 CN 116131683 B, 授权公告日 2018-01-04.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide in Pharmaceutical Formulations". Sci. Total Environ., 2023, 824, 2814-2824.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide as an Impurity". Anal. Methods, 2017, 887, 3294-3319.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of (3a,5b,12a)-N,N-Bis[3-(D-gluconoylamino)propyl]-3,12-dihydroxycholan-24-amide 86303-23-3 Deoxy-BigCHAP N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide big chap, deoxy deoxy-bigchap(n,n-bis[3-glucoriamidopropyl]-deoxycholamide deoxybigchap=bigchap,deoxy n,n'-bis(3-d-gluconamidopropyl)-deoxy-cholamide n,n-bis(3-gluconamidopropyl)deoxycholamide n,n-bis-(3-d-gluconamidopropyl)deoxycholamide Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2019, 1592, (1), 8351-8378.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate N,N-Bis[3-(D-gluconamido)propyl]deoxycholamide Profile in Drug Substances According to ICH Guidelines". Talanta, 2019, 396, 9973-9986.

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