甲醇钾 溶液 CAS 865-33-8

865-33-8 A841711 sodium 2-[[(1S,2S,3aR,9aR)-2-hydroxy-1-[(3R)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetate sodium 2-[[(1S,2S,3aR,9aR)-2-oxidanyl-1-[(3R)-3-oxidanyloctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]ethanoate

纯度 97%+现货药物标准品
CAS 号865-33-8
分子式K CH3O
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

甲醇钾 溶液 865-33-8 A841711 sodium 2-[[(1S,2S,3aR,9aR)-2-hydroxy-1-[(3R)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetate sodium 2-[[(1S,2S,3aR,9aR)-2-oxidanyl-1-[(3R)-3-oxidanyloctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]ethanoate CAS 865-33-8 结构式 Chemical Structure

产品介绍 Description

甲醇钾 溶液（英文名 865-33-8 A841711 sodium 2-[[(1S,2S,3aR,9aR)-2-hydroxy-1-[(3R)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetate sodium 2-[[(1S,2S,3aR,9aR)-2-oxidanyl-1-[(3R)-3-oxidanyloctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]ethanoate，CAS 865-33-8）属于药物标准品。分子式 K CH3O。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 化学式为 K CH3O 的甲醇钾 溶液（865-33-8 A841711 sodium 2-(1S,2S,3aR,9aR)-2-hydroxy-1-(3R)-3-hydroxyoctyl-2,3,3a,4,9,9a-hexahydro-1H-cyclopentagnaphthalen-5-yloxyacetate sodium 2-(1S,2S,3aR,9aR)-2-oxidanyl-1-(3R)-3-oxidanyloctyl-2,3,3a,4,9,9a-hexahydro-1H-cyclopentagnaphthalen-5-yloxyethanoate），其CAS登记号是 865-33-8，分子量为 70.13 g/mol。 甲

应用场景：甲醇钾 溶液（865-33-8 A841711 sodium 2- (1S,2S,3aR,9aR)-2-hydroxy-1- (3R)-3-hydroxyoctyl -2,3,3a,4,9,9a-hexahydro-1H-cyclopenta g naphthalen-5-yl oxy acetate sodium 2- (1S,2S,3aR,9aR)-2-oxidanyl-1- (3R)-3-oxidanyloctyl -2,3,3a,4,9,9a-hexahydro-1H-cyclopenta g naphthalen-5-yl oxy ethanoate，CAS 865-33-8）的

理化性质 Physical & Chemical Properties

中文名称甲醇钾 溶液
分子式K CH3O
分子量70.13 g/mol
外观形态白色至类白色液体
纯度97%+
储存条件2-8°C冷藏保存
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）0.5
CAS登记年份（估）1957年

相关专利 Related Patents

  1. 发明人马晓峰，高志强，朱建伟. "一种甲醇钾 溶液的合成方法" [P]. 中国发明专利, 专利号 CN 117163196 B, 授权公告日 2019-01-16.
  2. 发明人韩伟，冯建国，王建平. "Method for the Synthesis of 865-33-8 A841711 sodium 2-[[(1S,2S,3aR,9aR)-2-hydroxy-1-[(3R)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetate sodium 2-[[(1S,2S,3aR,9aR)-2-oxidanyl-1-[(3R)-3-oxidanyloctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]ethanoate" [P]. 中国发明专利, 专利号 CN 114921585 A, 授权公告日 2019-09-01.
  3. 发明人马晓峰，高志强，周伟. "A Process for Preparing High-Purity 865-33-8 A841711 sodium 2-[[(1S,2S,3aR,9aR)-2-hydroxy-1-[(3R)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetate sodium 2-[[(1S,2S,3aR,9aR)-2-oxidanyl-1-[(3R)-3-oxidanyloctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]ethanoate" [P]. 中国发明专利, 专利号 CN 112630510 A, 授权公告日 2021-05-13.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 甲醇钾 溶液 in Pharmaceutical Formulations". Food Chem., 2010, 254, (9), 321-345.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 甲醇钾 溶液 as an Impurity". Chromatographia, 2019, 1048, (10), 1023-1050.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 865-33-8 A841711 sodium 2-[[(1S,2S,3aR,9aR)-2-hydroxy-1-[(3R)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetate sodium 2-[[(1S,2S,3aR,9aR)-2-oxidanyl-1-[(3R)-3-oxidanyloctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]ethanoate Using HRMS and NMR". Anal. Chem., 2015, 1945, 7446-7473.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 甲醇钾 溶液 Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2018, 874, (9), 2821-2844.

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