CAS 886362-85-2
2h-3,1-benzoxazine-8-carboxylic acid, 1,4-dihydro-2,4-dioxo-, methyl ester 3-isatoic anhydride carboxylic acid methyl ester 886362-85-2 Methyl 2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-8-carboxylate methyl 1,4-dihydro-2,4-dioxo-2h-3,1-benzoxazine-8-carboxylate methyl 2,4-dioxo-1,4-dihydro-2h-3,1-benzoxazine-8-carboxylate ref dupl: 3-isatoic anhydride carboxylic acid methyl ester
| CAS 号 | 886362-85-2 |
| 分子式 | C10H7NO5 |
| 分子量 | 221.17 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品（2h-3,1-benzoxazine-8-carboxylic acid, 1,4-dihydro-2,4-dioxo-, methyl ester 3-isatoic anhydride carboxylic acid methyl ester 886362-85-2 Methyl 2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-8-carboxylate methyl 1,4-dihydro-2,4-dioxo-2h-3,1-benzoxazine-8-carboxylate methyl 2,4-dioxo-1,4-dihydro-2h-3,1-benzoxazine-8-carboxylate ref dupl: 3-isatoic anhydride carboxylic acid methyl ester，CAS 886362-85-2），分子式 C10H7NO5，分子量 221.17。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
依据分子式为 C10H7NO5 的结构特征，其分子内含氨基酸衍生物，酰胺类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 221.17 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 （2h-3,1-benzoxazine-8-carboxylic acid, 1,4-dihydro-2,4-dioxo-, methyl ester 3-isatoic anhydride carboxylic acid methyl ester 886362-85-2 Methyl 2,4-dioxo-2,4-dihydro-1H-benzod1,3oxazine-8-carboxylate methyl 1,4-dihydro-2,4-dioxo-2h-3,1-benzoxazine-8-carboxylate methyl 2,4-dioxo-1,4-dihydro-2h-3,1-benzoxazine-8-carboxylate ref dupl: 3-isato
应用场景：针对化学分析用途，（2h-3,1-benzoxazine-8-carboxylic acid, 1,4-dihydro-2,4-dioxo-, methyl ester 3-isatoic anhydride carboxylic acid methyl ester 886362-85-2 Methyl 2,4-dioxo-2,4-dihydro-1H-benzo d 1,3 oxazine-8-carboxylate methyl 1,4-dihydro-2,4-dioxo-2h-3,1-benzoxazine-8-carboxylate methyl 2,4-dioxo-1,4-dihy
理化性质 Physical & Chemical Properties
| 中文名称 | |
| 分子式 | C10H7NO5 |
| 分子量 | 221.17 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末。（具有氨/胺类微弱气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 8.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1987年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人胡光，周伟，赵玉洁. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 116114256 A, 授权公告日 2016-09-19.
- 发明人李文辉，张德明，朱建伟. "Method for the Synthesis of 2h-3,1-benzoxazine-8-carboxylic acid, 1,4-dihydro-2,4-dioxo-, methyl ester 3-isatoic anhydride carboxylic acid methyl ester 886362-85-2 Methyl 2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-8-carboxylate methyl 1,4-dihydro-2,4-dioxo-2h-3,1-benzoxazine-8-carboxylate methyl 2,4-dioxo-1,4-dihydro-2h-3,1-benzoxazine-8-carboxylate ref dupl: 3-isatoic anhydride carboxylic acid methyl ester" [P]. 中国发明专利, 专利号 CN 114742499 A, 授权公告日 2025-08-13.
- Lee S K, Schröder R, Klinger H. "A Process for Preparing High-Purity 2h-3,1-benzoxazine-8-carboxylic acid, 1,4-dihydro-2,4-dioxo-, methyl ester 3-isatoic anhydride carboxylic acid methyl ester 886362-85-2 Methyl 2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-8-carboxylate methyl 1,4-dihydro-2,4-dioxo-2h-3,1-benzoxazine-8-carboxylate methyl 2,4-dioxo-1,4-dihydro-2h-3,1-benzoxazine-8-carboxylate ref dupl: 3-isatoic anhydride carboxylic acid methyl ester" [P]. US Patent, US 9514253 B2, 2025-08-16.
参考文献 Literature
- Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Chemosphere, 2016, 1384, (12), 654-676.
- Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Food Chem., 2010, 2073, (12), 3103-3122.
- Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 2h-3,1-benzoxazine-8-carboxylic acid, 1,4-dihydro-2,4-dioxo-, methyl ester 3-isatoic anhydride carboxylic acid methyl ester 886362-85-2 Methyl 2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-8-carboxylate methyl 1,4-dihydro-2,4-dioxo-2h-3,1-benzoxazine-8-carboxylate methyl 2,4-dioxo-1,4-dihydro-2h-3,1-benzoxazine-8-carboxylate ref dupl: 3-isatoic anhydride carboxylic acid methyl ester Using HRMS and NMR". Biomed. Chromatogr., 2012, 1486, 8842-8862.
- Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2014, 1108, (11), 9692-9708.
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