CAS 892-49-9
892-49-9 O532QJ0GH4 Arabinosyl-6-mercaptopurine 9-beta-D-Arabinofuranosyl-1,9-dihydro-6H-purine-6-thione 9-(beta-D-Arabinofuranosyl)-9H-purine-6-thiol 9H-Purine-6-thiol, 9-beta-D-arabinofuranosyl- 6H-Purine-6-thione, 9-beta-D-arabinofuranosyl-1,9-dihydro- (9CI) ARA-6MP beta-D-Arabinofuranosyl-6-mercaptopurine Arabinofuranosyl-6-mercaptopurine 9beta-Arabinofuranosyl-9-H-purine-6-thiol, D- 9-beta-D-Arabinofuranosyl-9H-purine-6-thiol 6MP-Arabinoside beta-D-Arabinosyl-6-mercaptopurine Ara-MP beta-Ara-6-MP BRN 5297846 EINECS 212-968-3 NSC-406021 6-Thio-9-beta-D-arabinofuranosylpurine NSC 406021 UNII-O532QJ0GH4
| CAS 号 | 892-49-9 |
| 分子式 | C10H12N4O4S |
| 分子量 | 284.29 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品（892-49-9 O532QJ0GH4 Arabinosyl-6-mercaptopurine 9-beta-D-Arabinofuranosyl-1,9-dihydro-6H-purine-6-thione 9-(beta-D-Arabinofuranosyl)-9H-purine-6-thiol 9H-Purine-6-thiol, 9-beta-D-arabinofuranosyl- 6H-Purine-6-thione, 9-beta-D-arabinofuranosyl-1,9-dihydro- (9CI) ARA-6MP beta-D-Arabinofuranosyl-6-mercaptopurine Arabinofuranosyl-6-mercaptopurine 9beta-Arabinofuranosyl-9-H-purine-6-thiol, D- 9-beta-D-Arabinofuranosyl-9H-purine-6-thiol 6MP-Arabinoside beta-D-Arabinosyl-6-mercaptopurine Ara-MP beta-Ara-6-MP BRN 5297846 EINECS 212-968-3 NSC-406021 6-Thio-9-beta-D-arabinofuranosylpurine NSC 406021 UNII-O532QJ0GH4，CAS 892-49-9），分子式 C10H12N4O4S，分子量 284.29。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
受分子结构中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键的影响，表现为类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味）。其固体形态的物理化学属性——包括284.29 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 化学式为 C10H12N4O4S 的（892-49-9 O532QJ0GH4 Arabinosyl-6-mercaptopurine 9-beta-D-Arabinofuranosyl-1,9-dihydro-6H-purine-6-thione 9-(beta-D-Arabinofuranosyl)-9H-purine-6-thiol 9H-Purine-6-thiol, 9-beta-D-arabinofuranosyl- 6H-Purine-6-thione, 9-beta-D-arabinofuranosyl-1,9-dihydro- (9CI) ARA-6MP beta-D-Arabinofurano
应用场景：在化学分析实验室中，（CAS 892-49-9）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。
理化性质 Physical & Chemical Properties
| 中文名称 | |
| 分子式 | C10H12N4O4S |
| 分子量 | 284.29 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 7.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1957年 |
| 含氮原子数 | 4 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- Park J H, Hughes D C, Roberts E F. "一种的合成方法" [P]. US Patent, US 10218501 B2, 2017-12-10.
- 发明人朱建伟，王建平，何建平. "Method for the Synthesis of 892-49-9 O532QJ0GH4 Arabinosyl-6-mercaptopurine 9-beta-D-Arabinofuranosyl-1,9-dihydro-6H-purine-6-thione 9-(beta-D-Arabinofuranosyl)-9H-purine-6-thiol 9H-Purine-6-thiol, 9-beta-D-arabinofuranosyl- 6H-Purine-6-thione, 9-beta-D-arabinofuranosyl-1,9-dihydro- (9CI) ARA-6MP beta-D-Arabinofuranosyl-6-mercaptopurine Arabinofuranosyl-6-mercaptopurine 9beta-Arabinofuranosyl-9-H-purine-6-thiol, D- 9-beta-D-Arabinofuranosyl-9H-purine-6-thiol 6MP-Arabinoside beta-D-Arabinosyl-6-mercaptopurine Ara-MP beta-Ara-6-MP BRN 5297846 EINECS 212-968-3 NSC-406021 6-Thio-9-beta-D-arabinofuranosylpurine NSC 406021 UNII-O532QJ0GH4" [P]. 中国发明专利, 专利号 CN 114780419 B, 授权公告日 2024-11-03.
参考文献 Literature
- Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Phytochemistry, 2022, 1354, 5240-5251.
- Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Talanta, 2018, 2263, 1780-1802.
- Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of 892-49-9 O532QJ0GH4 Arabinosyl-6-mercaptopurine 9-beta-D-Arabinofuranosyl-1,9-dihydro-6H-purine-6-thione 9-(beta-D-Arabinofuranosyl)-9H-purine-6-thiol 9H-Purine-6-thiol, 9-beta-D-arabinofuranosyl- 6H-Purine-6-thione, 9-beta-D-arabinofuranosyl-1,9-dihydro- (9CI) ARA-6MP beta-D-Arabinofuranosyl-6-mercaptopurine Arabinofuranosyl-6-mercaptopurine 9beta-Arabinofuranosyl-9-H-purine-6-thiol, D- 9-beta-D-Arabinofuranosyl-9H-purine-6-thiol 6MP-Arabinoside beta-D-Arabinosyl-6-mercaptopurine Ara-MP beta-Ara-6-MP BRN 5297846 EINECS 212-968-3 NSC-406021 6-Thio-9-beta-D-arabinofuranosylpurine NSC 406021 UNII-O532QJ0GH4 Using HRMS and NMR". Environ. Sci. Technol., 2024, 1397, (12), 181-199.
- Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2010, 1881, 2879-2889.
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