α-苯甲酰-ω-苯甲酰氧基-聚氧乙烯 CAS 9004-86-8
9004-86-8 Glycols, polyethylene, dibenzoate Poly(oxy-1,2-ethanediyl), alpha-benzoyl-omega-(benzoyloxy)- Benzoflex P 200 Benzoflex P-600 Benzoic acid diester with polyethylene glycol 600 Polyethylene 600 dibenzoate Polyethylene glycol 220 dibenzoate Polyethylene glycol dibenzoate Polyoxyethylene dibenzoate
| CAS 号 | 9004-86-8 |
| 分子式 | C7H12O2 C2H6O2 |
| 分子量 | N/A g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 9004-86-8 对应的α-苯甲酰-ω-苯甲酰氧基-聚氧乙烯（9004-86-8 Glycols, polyethylene, dibenzoate Poly(oxy-1,2-ethanediyl), alpha-benzoyl-omega-(benzoyloxy)- Benzoflex P 200 Benzoflex P-600 Benzoic acid diester with polyethylene glycol 600 Polyethylene 600 dibenzoate Polyethylene glycol 220 dibenzoate Polyethylene glycol dibenzoate Polyoxyethylene dibenzoate）为 CATO 佳途药物标准品产品线成员。分子式 C7H12O2 C2H6O2。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括α-苯甲酰-ω-苯甲酰氧基-聚氧乙烯在内的目标物的控制。 α-苯甲酰-ω-苯甲酰氧基-聚氧乙烯（9004-86-8 Glycols, polyethylene, dibenzoate Poly(oxy-1,2-ethanediyl), alpha-benzoyl-omega-(benzoyloxy)- Benzoflex P 200 Benzoflex P-600 Benzoic acid diester with polyethylene glycol 600 Polyethylene 600 dibenzoate Polyethylene glycol 220 dibenzoate Polyethylene glycol dibenzoate Polyoxyethylene dibenzoate），CAS注册编号 9004-86-8，化学分子式为 C7H12O2 C2H6O2，分子量 190.24 g/mol。 受分子结构中羧酸类，含羟基，含醚键的影响，α-苯甲酰-ω-苯甲酰氧基-聚氧乙烯表现为白色至类白色结晶性粉末。
应用场景：针对化学分析用途，α-苯甲酰-ω-苯甲酰氧基-聚氧乙烯（9004-86-8 Glycols, polyethylene, dibenzoate Poly(oxy-1,2-ethanediyl), alpha-benzoyl-omega-(benzoyloxy)- Benzoflex P 200 Benzoflex P-600 Benzoic acid diester with polyethylene glycol 600 Polyethylene 600 dibenzoate Polyethylene glycol 220 dibenzoate Polyethylene glycol dib
理化性质 Physical & Chemical Properties
| 中文名称 | α-苯甲酰-ω-苯甲酰氧基-聚氧乙烯 |
| 分子式 | C7H12O2 C2H6O2 |
| 分子量 | 190.24 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 1.0 |
| CAS登记年份（估） | 1959年 |
相关专利 Related Patents
- 发明人郭海燕，黄志刚，沈红梅. "一种α-苯甲酰-ω-苯甲酰氧基-聚氧乙烯的合成方法" [P]. 中国发明专利, 专利号 CN 117346377 A, 授权公告日 2022-06-09.
- 发明人张德明，胡光，马晓峰. "Method for the Synthesis of 9004-86-8 Glycols, polyethylene, dibenzoate Poly(oxy-1,2-ethanediyl), alpha-benzoyl-omega-(benzoyloxy)- Benzoflex P 200 Benzoflex P-600 Benzoic acid diester with polyethylene glycol 600 Polyethylene 600 dibenzoate Polyethylene glycol 220 dibenzoate Polyethylene glycol dibenzoate Polyoxyethylene dibenzoate" [P]. 中国发明专利, 专利号 CN 111204258 B, 授权公告日 2020-10-08.
- Nielsen H, Mueller T C, Johansson L. "A Process for Preparing High-Purity 9004-86-8 Glycols, polyethylene, dibenzoate Poly(oxy-1,2-ethanediyl), alpha-benzoyl-omega-(benzoyloxy)- Benzoflex P 200 Benzoflex P-600 Benzoic acid diester with polyethylene glycol 600 Polyethylene 600 dibenzoate Polyethylene glycol 220 dibenzoate Polyethylene glycol dibenzoate Polyoxyethylene dibenzoate" [P]. European Patent, EP 3071919 A1, 2021-11-06.
参考文献 Literature
- Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of α-苯甲酰-ω-苯甲酰氧基-聚氧乙烯 in Pharmaceutical Formulations". Anal. Chem., 2011, 2253, 6954-6963.
- Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of α-苯甲酰-ω-苯甲酰氧基-聚氧乙烯 as an Impurity". J. Chromatogr. A, 2019, 200, (7), 8007-8022.
- Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 9004-86-8 Glycols, polyethylene, dibenzoate Poly(oxy-1,2-ethanediyl), alpha-benzoyl-omega-(benzoyloxy)- Benzoflex P 200 Benzoflex P-600 Benzoic acid diester with polyethylene glycol 600 Polyethylene 600 dibenzoate Polyethylene glycol 220 dibenzoate Polyethylene glycol dibenzoate Polyoxyethylene dibenzoate Using HRMS and NMR". Food Chem., 2017, 1087, (11), 4081-4098.
- Martinez C, Lopez D R. "Forced Degradation Studies to Evaluate α-苯甲酰-ω-苯甲酰氧基-聚氧乙烯 Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2021, 1569, (12), 1038-1060.
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