异氰酸 4-联苯酯 CAS 92-95-5

B0ZSP4UPQ4 92-95-5 4-Biphenylyl isocyanate UNII-B0ZSP4UPQ4 p-Xenylcarbimide [MI] 1,1'-Biphenyl, 4-isocyanato- p-Xenylcarbimide 4-Biphenyl isocyanate 4-Isocyanatobiphenyl 4-Phenylphenyl isocyanate p-Diphenyl isocyanate p-Phenylphenyl isocyanate

纯度 97%+现货药物标准品
CAS 号92-95-5
分子式C13H21NO
分子量207.31 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

异氰酸 4-联苯酯 B0ZSP4UPQ4 92-95-5 4-Biphenylyl isocyanate UNII-B0ZSP4UPQ4 p-Xenylcarbimide [MI] 1,1'-Biphenyl, 4-isocyanato- p-Xenylcarbimide 4-Biphenyl isocyanate 4-Isocyanatobiphenyl 4-Phenylphenyl isocyanate p-Diphenyl isocyanate p-Phenylphenyl isocyanate CAS 92-95-5 结构式 Chemical Structure

产品介绍 Description

异氰酸 4-联苯酯（英文名 B0ZSP4UPQ4 92-95-5 4-Biphenylyl isocyanate UNII-B0ZSP4UPQ4 p-Xenylcarbimide [MI] 1,1'-Biphenyl, 4-isocyanato- p-Xenylcarbimide 4-Biphenyl isocyanate 4-Isocyanatobiphenyl 4-Phenylphenyl isocyanate p-Diphenyl isocyanate p-Phenylphenyl isocyanate，CAS 92-95-5）属于药物标准品。分子式 C13H21NO，分子量 207.31。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

异氰酸 4-联苯酯的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 92-95-5 对应的化合物异氰酸 4-联苯酯（英文标识 B0ZSP4UPQ4 92-95-5 4-Biphenylyl isocyanate UNII-B0ZSP4UPQ4 p-Xenylcarbimide MI 1,1'-Biphenyl, 4-isocyanato- p-Xenylcarbimide 4-Biphenyl isocyanate 4-Isocyanatobiphenyl 4-Phenylphenyl isocyanate p-Diphenyl isocyanate p-Phenylphenyl isocyanate），化学式 C13H21NO，相对分子质量 207.31。 异氰酸 4-联苯酯（分子式 C13H21NO）的化学结构中包含含氮杂环结构，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受其较高的疏水性（logP）影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。分

应用场景：针对化学分析用途，异氰酸 4-联苯酯（B0ZSP4UPQ4 92-95-5 4-Biphenylyl isocyanate UNII-B0ZSP4UPQ4 p-Xenylcarbimide MI 1,1'-Biphenyl, 4-isocyanato- p-Xenylcarbimide 4-Biphenyl isocyanate 4-Isocyanatobiphenyl 4-Phenylphenyl isocyanate p-Diphenyl isocyanate p-Phenylphenyl isocyanate）是具有明确定量溯源的认证级对照品。 推荐以异氰酸 4-联苯酯配制标准系列

理化性质 Physical & Chemical Properties

中文名称异氰酸 4-联苯酯
分子式C13H21NO
分子量207.31 g/mol
外观形态类白色至淡黄色低熔点固体
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年
含氮原子数1

相关专利 Related Patents

  1. 发明人刘建华，孙丽萍，钱学锋. "一种异氰酸 4-联苯酯的合成方法" [P]. 中国发明专利, 专利号 CN 113596767 B, 授权公告日 2018-02-14.
  2. 发明人孙丽萍，罗永刚，沈红梅. "Method for the Synthesis of B0ZSP4UPQ4 92-95-5 4-Biphenylyl isocyanate UNII-B0ZSP4UPQ4 p-Xenylcarbimide [MI] 1,1'-Biphenyl, 4-isocyanato- p-Xenylcarbimide 4-Biphenyl isocyanate 4-Isocyanatobiphenyl 4-Phenylphenyl isocyanate p-Diphenyl isocyanate p-Phenylphenyl isocyanate" [P]. 中国发明专利, 专利号 CN 113354701 A, 授权公告日 2025-01-28.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of 异氰酸 4-联苯酯 in Pharmaceutical Formulations". Biomed. Chromatogr., 2020, 1223, (10), 3814-3822.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 异氰酸 4-联苯酯 as an Impurity". Molecules, 2023, 1841, (4), 125-142.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of B0ZSP4UPQ4 92-95-5 4-Biphenylyl isocyanate UNII-B0ZSP4UPQ4 p-Xenylcarbimide [MI] 1,1'-Biphenyl, 4-isocyanato- p-Xenylcarbimide 4-Biphenyl isocyanate 4-Isocyanatobiphenyl 4-Phenylphenyl isocyanate p-Diphenyl isocyanate p-Phenylphenyl isocyanate Using HRMS and NMR". J. Nat. Prod., 2023, 165, (7), 6337-6344.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 异氰酸 4-联苯酯 Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2019, 1445, 9186-9205.

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